Association of Fibrosis in Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia

[waynakyo]

Forthcoming in a top 5 journal (not very common for male pattern baldness studies). Unfortunately no abstract, but I pulled a figure from the paper
The paper is simple: They find evidence of fibrosis in the bulge of the follicle itself. They say that drugs that can act on fibrosis can hold promise for baldness.

 

[waynakyo]

It is based on people, about 30 follicles taken from a dozen of Chinese men. From donor and recipient, as well as from non-male pattern baldness folks.

 

[FollicleGuardian]

Thanks for sharing all this research! I really appreciate it.

 

[pegasus2]

I was really looking forward to this study until Tsuji stole their thunder

 

[inmyhead]

Wonder what is it, because you could also assume that fibrosis is result of having less follicles and is not causing balding itself. Looking forward.

 

[pegasus2]

Wonder what is it, because you could also assume that fibrosis is result of having less follicles and is not causing balding itself. Looking forward.

Right, but when fibrosis sets in it prevents the reversal of hair loss. I hope there some hint in there about reversing fibrosis.

 

[Selb]

I think calcipotriol has some evidence of reducing fibrosis. Apply that with microneedling to get as close to the bulge regions and you could get a local reversal of the fibrosis

 

[pegasus2]

Spironolactone, eplerenone, and minoxidil too. Reversal is limited though.

 

[MrOscar]

I think calcipotriol has some evidence of reducing fibrosis. Apply that with microneedling to get as close to the bulge regions and you could get a local reversal of the fibrosis

Any experience here on topical calcipotriol?

 

[FollicleGuardian]

DMSO has collagen dissolution properties which can help reverse fibrosis.

Dimethyl Sulfoxide - an overview | ScienceDirect Topics

www.sciencedirect.com

 

[ElToso]

Calcipotriol was often mentioned by eldarlmario

https://www.baldtruthtaIk.com/threa...enetic-reasons-why-we-balding-men-are-balding

 

[Ganked By DHT]

wasnt sodium thiosulfate used for calcification?

 

[waynakyo]

Did you guys miss my post on fibrosis drugs? Since it seems that's where the conversation turned too, the article I shared has dozens of drugs.

 

[Will Be an Egg in 5 years]

I don't understand why these other drugs aren't studied more.

 

[Jakejr]

I think calcipotriol has some evidence of reducing fibrosis. Apply that with microneedling to get as close to the bulge regions and you could get a local reversal of the fibrosis

wasnt sodium thiosulfate used for calcification?

You can buy it on EBay

 

[StayPositive]

Any experience here on topical calcipotriol?

I use calcipotriol every night for scalp psoriasis, it works extremely well for my condition but doesn't seem to do much with hair loss. But who knows, maybe it's beneficial.

There are other things helping with fibrosis: taurine, l carnitine l tartrate, melatonin, caffeine and probably PGD2 inhibitors (Setipiprant, TM30089, OC000459)

 

[EndlessPossibilities]

I use calcipotriol every night for scalp psoriasis, it works extremely well for my condition but doesn't seem to do much with hair loss. But who knows, maybe it's beneficial.

There are other things helping with fibrosis: taurine, l carnitine l tartrate, melatonin, caffeine and probably PGD2 inhibitors (Setipiprant, TM30089, OC000459)

Have u noticed it stopped hairloss at least?

 

[StayPositive]

Have u noticed it stopped hairloss at least?

No it doesn't do anything for my hair