Any minoxidil non-responders here who are now responding with microneedling & minoxidil?

nick123

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I'm someone who never responded to minoxidil most likely because I lack follicular sulfotransferase enzymes which are the enzymes minoxidil interacts with in order to promote hair growth.

There's this study here that states microneedling upregulates sulfotransferase enzymes: https://pubmed.ncbi.nlm.nih.gov/32492993/

That being said are there any minoxidil non-repsonders here that now respond to minoxidil because they've added microneedling to their regime?
 

CJ_Frankfurt

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I‘m currently trying to get results with the minoxidil-microneedling combo and after two months it seems to work. I apply minoxidil straight after needling with a 0.5 mm depth (Derminator 2). Besides my scalp I used Tretinoin 0.1 to promote beard growth and that definitely was a game changer. Unfortunately the skin on my scalp is to sensitive to tret application.
 

Equal Rights

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I‘m currently trying to get results with the minoxidil-microneedling combo and after two months it seems to work. I apply minoxidil straight after needling with a 0.5 mm depth (Derminator 2). Besides my scalp I used Tretinoin 0.1 to promote beard growth and that definitely was a game changer. Unfortunately the skin on my scalp is to sensitive to tret application.
You use min on your beard too? Or only tret?
 

CJ_Frankfurt

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You use min on your beard too? Or only tret?
Yes, I do. But I combine it with minoxidil. First I apply the minoxidil foam and 10 minutes later I apply the tretinoin creme 0.1. And it definitely works. I had no beard on my cheeks at all and since applying the tret-minoxidil combo hair comes out of nowhere. I’m currently 39 years old and I never had a beard on my cheeks. Now I‘m going to change that. But I also have to admit that it takes time. It’s a very slow process. Don’t expect a miracle. Consistency is king and the skin will be very dry. And please consult your physician if there are any concerns. Good luck!
 

jamesbooker1975

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I'm someone who never responded to minoxidil most likely because I lack follicular sulfotransferase enzymes which are the enzymes minoxidil interacts with in order to promote hair growth.

There's this study here that states microneedling upregulates sulfotransferase enzymes: https://pubmed.ncbi.nlm.nih.gov/32492993/

That being said are there any minoxidil non-repsonders here that now respond to minoxidil because they've added microneedling to their regime?
Just get tretinoin, much safer and easier .
 

cj79

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I always believed you shouldn't use minoxidil for 24hrs after dermarolling
 

jamesbooker1975

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I've seen a lot of great results with Minoxidil + Microneedling, I've yet to see a great response from Minoxidil + Tretinoin.
Lol. It have being use it since late 80s . It was in the first formula of Xandrox that made Dr Lee hair loss lotion so popular . Search for the study done in 2019 .
Plus, I don't think nobody really undersntad the dangerous of microneeding on chronically damage the scalp and also the risk of infection.
 

Lurker otto

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Lol. It have being use it since late 80s . It was in the first formula of Xandrox that made Dr Lee hair loss lotion so popular . Search for the study done in 2019 .
Plus, I don't think nobody really undersntad the dangerous of microneeding on chronically damage the scalp and also the risk of infection.
What percentage of tret do you recommend? 0.1 or 0.05?
 

-Synergy-

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I‘m currently trying to get results with the minoxidil-microneedling combo and after two months it seems to work. I apply minoxidil straight after needling with a 0.5 mm depth (Derminator 2). Besides my scalp I used Tretinoin 0.1 to promote beard growth and that definitely was a game changer. Unfortunately the skin on my scalp is to sensitive to tret application.

So you mean you were a non responder to minoxidil? Now that you added microneedling your getting slightly visible results at the 2 month mark? I just want to make sure I understand. Tretinoin 0.1% might be way too much. I think the usual dosage for hair to avoid vitamin A overdosed follicles, skin irritation, and increased sulta1a for better minoxidil efficacy is tretinoin 0.01% - 0.025%. Retinol might be good at 0.1% because it has to go through a three stage conversion process before being converted to retinoic acid or generic tretinoin. Only a small amount of retinol turns into retinoic acid. At least that’s what the stuff I have been reading claims.
 

Isneezedsohard

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So you mean you were a non responder to minoxidil? Now that you added microneedling your getting slightly visible results at the 2 month mark? I just want to make sure I understand. Tretinoin 0.1% might be way too much. I think the usual dosage for hair to avoid vitamin A overdosed follicles, skin irritation, and increased sulta1a for better minoxidil efficacy is tretinoin 0.01% - 0.025%. Retinol might be good at 0.1% because it has to go through a three stage conversion process before being converted to retinoic acid or generic tretinoin. Only a small amount of retinol turns into retinoic acid. At least that’s what the stuff I have been reading claims.
I’m thinking of just switching to 2.5 mg oral min. I think topicals just irritate my scalp.
 

-Synergy-

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I’m thinking of just switching to 2.5 mg oral min. I think topicals just irritate my scalp.
What topicals irritate your scalp? Like propylene glycol and alcohol? The ph level of skin products might play a role. They say anything that you put on your skin that has a high ph can be irritating. I’m trying this new formula with an isopropyl alcohol and vegetable glycerin base. It has retin-a and I hope that it works better without irritation.
 

Isneezedsohard

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What topicals irritate your scalp? Like propylene glycol and alcohol? The ph level of skin products might play a role. They say anything that you put on your skin that has a high ph can be irritating. I’m trying this new formula with an isopropyl alcohol and vegetable glycerin base. It has retin-a and I hope that it works better without irritation.
I think most topicals in general. The less the better. PG made my hair shed like a b**ch-- which is why I switched from liquid to foam min. But most topicals make my hair feel a lot more brittle I have found
 

Isneezedsohard

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What topicals irritate your scalp? Like propylene glycol and alcohol? The ph level of skin products might play a role. They say anything that you put on your skin that has a high ph can be irritating. I’m trying this new formula with an isopropyl alcohol and vegetable glycerin base. It has retin-a and I hope that it works better without irritation.
I'm also just kind of over having to worry about taking 30 min out of my day to apply topicals. I much rather just pop a pill and get on with my day
 

-Synergy-

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I'm also just kind of over having to worry about taking 30 min out of my day to apply topicals. I much rather just pop a pill and get on with my day
I wish you luck with oral minoxidil. I tried to make oral minoxidil work but my body didn’t want to allow it.
 
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