Antipsychotics really are, some can interfere with the heart rhythm and it's a life threatening emergency or feeling sedated, impaired cognition, weight gain etc. But again, if that person is at risk of suicide or harming others due to psychosis, the pros outweigh the cons. Antidepressants change lives too in a positive way for some people, if they are needed long term it's better than the pain of suffering, failure and bad lifestyle habits. And like you wrote once to DH, they don't change your beliefs with therapy like about looks (logically), just they rebalance the biochemistry of the brain = more energy, drive to see things in perspective and get the best out of your life whatever your goals maybe and numb the pain. Depression can be physiological, endogenous and not always a reaction to something in the past/present - but can also be the latter or both.