2019 Consensus Of Setipiprant? Does It Work, Is It Worth It, When Can We Expect It Mainstream?

RecoveringMinoxAddict

Established Member
My Regimen
Reaction score
25
1. Does it work?

2. Are there studies proving it works?

3. Are there anecdotal user cases proving it works?

4. If it works, can it regrow temple hair?

5. What are risks of sides?

6. if it works, why is not not publicly available at pharmacies yet? What is the catch?
 

Pigeon

Senior Member
My Regimen
Reaction score
3,401
Now for some srs feed back, I have experience with seti.

Does it work? Yes for some even on low doses but don't expect regrowth, it's only for maintenance. Compare it with results of fina.

But it's very expensive and it's getting harder to import the stuff.

Also Novartis will release fevi in the upcoming years, it's the stronger seti version.

I quit seti but It really did help for me. Now I'm on the microneedling train and testing that.
 

ffar1989

Established Member
My Regimen
Reaction score
111
It is going to be as good as finasteride at best. For me it is great deal, since finasteride kills dicks.
 

TK421

Experienced Member
My Regimen
Reaction score
499
Took it orally, didn't do anything for me. Not sure if I took a high enough dosage, though. I think I took around 1000 - 1200 mgs./day for 4-6 weeks or so. No reduction in itching or shedding. Bought it from Lyphar.
 
Last edited:

balda

Member
My Regimen
Reaction score
15
It may work.

Setipiprant is one of pgd2 receptor antagonist, ie fibrosis prevention stuff. It's able to prevent, but not to revert fibrosis.
According to DWAT hypothesis, androgens can provike lypolysis and fibrosis in the dermal adipose tissue. Prevention is good, but could be not enough, if you already baldy. Seti effect could be similar to finasterid, but without hormonal sides.

To cure balding you need to include fibrosis reversion stuff!

See more in the thread "DWAT: Dermal White Adipose Tissue Hypothesis":
 

Pigeon

Senior Member
My Regimen
Reaction score
3,401
Maybe seti could help and slowdown but the problem is finding a good and safe source. I took it orally years ago and it slowed down hairloss but it was a pain to get hold off.
 

pegasus2

Senior Member
My Regimen
Reaction score
3,218
If it didn't work in a controlled trial paid for by a company that had an interest in making sure it worked, what makes you think it will work for you?
 

it2wi

New Member
Reaction score
8
Seti did work for me - halted shedding almost down to 0. This paired with needling I was able to regrow down to my juvenile hairline.
Important to note: I was applying it ***topically***, not ingesting it orally. The clinical trials were orally administered, and results were insufficient.. not surprised. Seti did/does work topically, but it has a short half life and is expensive (I was applying it topically 2x a day).

I don't know why folks love to dismiss Seti, and/or point to the clinical trials as proof. There is a difference between oral and topical effectiveness. Allergan likely went the oral route to make it dummy-proof to administer.

And for folks who say the PGD2 angle doesn't work, we have plenty of proof that PGE2 works (minoxidil, dermaneedling...). PGD2 / PGE2 = two sides of the same coin.

Sad that we are still debating the validity of tackling PGD2 in 2021, whereas should be figuring out how to get our hands on PGD2 antagonists.
 

TurboFixer

Established Member
My Regimen
Reaction score
74
Seti did work for me - halted shedding almost down to 0. This paired with needling I was able to regrow down to my juvenile hairline.
Important to note: I was applying it ***topically***, not ingesting it orally. The clinical trials were orally administered, and results were insufficient.. not surprised. Seti did/does work topically, but it has a short half life and is expensive (I was applying it topically 2x a day).

I don't know why folks love to dismiss Seti, and/or point to the clinical trials as proof. There is a difference between oral and topical effectiveness. Allergan likely went the oral route to make it dummy-proof to administer.

And for folks who say the PGD2 angle doesn't work, we have plenty of proof that PGE2 works (minoxidil, dermaneedling...). PGD2 / PGE2 = two sides of the same coin.

Sad that we are still debating the validity of tackling PGD2 in 2021, whereas should be figuring out how to get our hands on PGD2 antagonists.
Down to your juvenile hairline!
As in you are cured of this disease(at lest visually)? or are these like vellus peach fuzz hairs

did you stop using it ?
And most importantly can you please please please share photos
 

it2wi

New Member
Reaction score
8
Down to your juvenile hairline!
As in you are cured of this disease(at lest visually)? or are these like vellus peach fuzz hairs

did you stop using it ?
And most importantly can you please please please share photos
Hey - yeah complete recovery.

I stopped using it for a few reasons:
1) Life got busy and I figured it would be a good chance to see how long I could maintain the gains when stopping Seti
2) It was pricey and figured with my gains I may be able to hold off until Fevi (more potent) came out
3) After seeing the effectiveness of Seti, I was calmed to know that even if I stop and lose my gains, I could easily get them back again

Here are my photos (not the best)
 

LouisSarkozy

Established Member
My Regimen
Reaction score
60
Sure, regimen was:
Once a week dermaneedling (with the Derminator), 1.5mm on the fastest speed setting, 9 needle head
can i asked you what dosage you used and what was your supplier? i'm a non responder to AA therapies so maybe tackling pgd2 could help me ( i tried prostaquinon from fagron but it didn't do sh*t and i got some ceti in the fridge i'm just too lazy to use it atm) thx
 

balda

Member
My Regimen
Reaction score
15
@it2wi
many thanks.
if you don't mind, i would like to ask you more questions:

- have seen many photos with nw0 regrowth from Setipiprant, but the regrown hairs remained very thin and small, kind of non-terminal or so. have seen the same results? has it discussed? i would like to understand the conditions and regimen when Seti works and when it doesn't. attached an example.

- how much did Seti cost that time? I see $2000/gram in one place and $30/gram and even less in another one.

- have you came across Bimatoprost or other Seti-like PGD2 pathway blockers? seen anyone who tried them?
 

Attachments

  • aa.jpg
    aa.jpg
    64.6 KB · Views: 21
Top