It doesn't say that a high concentration of Sandalore causes these opposite effects.It says that the OR2AT4 knock-down causes these effects. OR2AT4 is being knocked-down by Phenirat, not by Sandalore. As stated in the paragraph above they co-admistered Sandalore with Phenirat. "The Sandalore...
I'm not trolling, not everything dissolves almost instantly in everything where it's soluble in (you could speed this process up by increasing the velocity of the molecules (shaking or warming up))
put a big piece of salt in a glass of water, it will also take hours until it's completely dissolved
This won't work, on the chemical point of view, it makes no difference wether you first dissolve the Sandalore in a solvent and then add water or wether you first mix the solvent with water and then add Sandalore.
Try doing it with a higher concentration of Sandalore, then you will clearly see...