Yet another topical finasteride study

[SoThatsLife]

Bryan, what have you read since the first post in this tread, since you have stated other places that topical finasteride gets systematically absorbed?

 

[JWM]

But CCS, it has been shown that a higher finasteride dose DOES help with hair counts. 5 mg. grew more hair than 1 mg.

 

[wesleyBelgium]

0,5mg duta grows also more hair then 5mg fina...

also from the former posts : mixing duta caps in your minoxidil , could break down after 2 weeks...
i have done this in the past , and notice after 2 weeks that my minoxidil turns more kinda white , had also hairloss after a few weeks use
i dont now for sure its actually hairloss or a shedding, but if you allready take duta oral , mixing it in your minoxidil will not make mutch of diffrence
it could be 2 things : the minoxidil is worthless after 2 weeks mixed up with duta, and so i get hairloss, or its a shedding, dont wanne take the risk...

for the moment i mix 0,5ml flutamide with 1,5ml minoxidil in a cup and then put it on my head, got lots of regrowth for the moment...
i dont use fluridil , but the 2% flutamide of genhair , but only mix 0,5ml in my minoxidil to avoid getting sides with it.... (genhair recommends 1ml 2x day)

 

[justaguy2005]

Is it absorbed systemically? Or is the dosage so low compared to oral preparations that it would have a negligible effect even if it were?

 

[CCS]

But CCS, it has been shown that a higher finasteride dose DOES help with hair counts. 5 mg. grew more hair than 1 mg.

Yeah, 20% more above baseline. But that is with 5x the dose. Yeah, the topical could help you. Just a question of how much and the cost of the extra pills. We just don't know how many pills it would take to achieve the same results as the oral dose.

 

[lordhair]

I think all you would need is one 5mg tablet for 100ml solution.

Only one tablet? Sorry my maths is terrible

 

[CCS]

I think all you would need is one 5mg tablet for 100ml solution.

Only one tablet? Sorry my maths is terrible

He means that is the dose they used in some of those studies. Who knows what the best dose is. There is the effective dose, and then the dose that gives some people side effects, and I think the vehicle is the most important factor.

 

[JWM]

Well 1 Proscar tablet per bottle of Rogaine would certainly be economical if nothing else.

 

[Bryan]

Bryan, what have you read since the first post in this tread, since you have stated other places that topical finasteride gets systematically absorbed?

I'm not sure I understand your question. I've stated several times that the results of topical finasteride studies have been all over the map: sometimes it was absorbed systemically, sometimes it wasn't; sometimes topical finasteride actually worked as intended, and sometimes it didn't.

 

[justaguy2005]

So if I'm currently taking Dutasteride EOD and I'm looking to ditch it (makes me fat), is squeezing some pills into Rogaine likely to be as effective with fewer side effects? That's what I infer from this study, though I realize it's not the same drug and all. Am I crazy?

 

[lordhair]

I think all you would need is one 5mg tablet for 100ml solution.

Only one tablet? Sorry my maths is terrible

He means that is the dose they used in some of those studies. Who knows what the best dose is. There is the effective dose, and then the dose that gives some people side effects, and I think the vehicle is the most important factor.

I see.

So 1 x 5mg tablet to 100ml would be a 0.05mg dose if I applied it twice a day. I'll give it a go

 

[Fundi]

So am I right in saying topical finasteride does work and since it doesn't affect hormones in the blood stream, does not carry the usual sides?

 

[lordhair]

So am I right in saying topical finasteride does work and since it doesn't affect hormones in the blood stream, does not carry the usual sides?

Noone knows for sure whether it works or not because the studies have had different conclusions

This one found that there was no systemic side effects but the dosage of finasteride used was very low

 

[kento]

So am I right in saying topical finasteride does work and since it doesn't affect hormones in the blood stream, does not carry the usual sides?

Noone knows for sure whether it works or not because the studies have had different conclusions

This one found that there was no systemic side effects but the dosage of finasteride used was very low

How much low if we compare it with daily intake of oral finasteride?

 

[CCS]

the studies used different vehicles. the "vehicle" is the liquid the finasteride is in. Some got no results, some gave side effects, some regrew or maintained hair just as well as propecia. The study with the best results used 25% water, 50% alcohol, 25% propylene glycol. I don't remember the finasteride concentration, but it was low. There were 50 guys in the study, so I would not trust my hair to such a small study, especially since it was 6 months. Many guys can't handle topical propylene glycol either. It turns my brother's scalp red. I handle it just fine though.

BAsically, if you use their exact mixture, then maybe you will do just fine. If you get experimental with some other vehicle, or put it in your minoxidil, there is a possibility it won't work and you will find out later when your hair is thinner, which won't be until after your minoxidil results peak. But since minoxidil does not slow the balding process, and is kind of like delayed realistic toppik, you will be kind of out of luck.

If you know you can't handle oral propecia, and you are using minoxidil anyway, go ahead and add a pill or two to the mix. It might help. But don't leave your oral propecia for a unknown like this if the propecia is working for you without sides.

 

[spinner2]

I just tried to make 0.01% topical finasteride with 25%PG, 75% ethanol. I had problems getting the crushed finasteride to mix, and lots of sediment is still at the bottom.

Anybody who made their own topical have any advice?

 

[Bryan]

I just tried to make 0.01% topical finasteride with 25%PG, 75% ethanol. I had problems getting the crushed finasteride to mix, and lots of sediment is still at the bottom.

That's almost certainly just some tablet excipients which aren't dissolving. Always crush the tablets into a fine powder before adding it to your vehicle, and shake vigorously. Keep in mind that there will probably ALWAYS be some sediment left over that won't dissolve.

 

[el_duterino]

0.01 % ?? that's sounds very low..not sure if it will be very effective since even a smaller percentage will go to the deep skin layer.
i used a 1 % finasteride topical (Finasgel) and it seemed to work ok. No side effects !
I stopped using it because i have no time for one more topical and the gel was a pain to apply and left residues,

 

[Fundi]

I'd like to make a finasteride topical with a low percentage - I imagine you'd use around 2ml per application - And in this application I'd want no more than 0.25mg.

Can anyone advise me on how to go about it? And if I can mix this with spironolactone cream? (A lot to ask I know)

 

[spinner2]

0.01% was supposed to be successful in one of the studies done.

I think 0.05% would be the highest I'd go. That's 5 fincar tablets per month (dissolved in 50ml solution).