World Congress For Hair Research 2017 - Posters

[lemoncloak]

"unidirectional protrusions toward the wound (W)"...yep it matches what Tsuji said about the importance of the wound direction pre DPs cells injections

But i found another study suggesting that Planar cell polarity fails on very large surface wounds, on mice the pattern was going crazy

Yes I remember reading the signal starts off from a point (a whirl) and then gets amplified from cell to cell outwards, like ripples in water. Somehow the signal gets lost the further it gets

 

[ThanksGramps]

This poster looks like good news for the Tsuji/Riken project: https://i.imgur.com/zurvYuI.jpg

"Maintenance and long-term expansion of murine skin epithelial stem cells by Wnt signalling pathway"

It looks like this group published a similar study in 2015: http://www.sciencedirect.com/science/article/pii/S0022202X15372894

I wonder if they've improved their method since then. (I'm not sure how the 2017 poster's method or results differ from the 2015 article).

 

[Armando Jose]

Thank you Hellouser for your fantastic work

 

[kingjohn]

This poster looks like good news for the Tsuji/Riken project: https://i.imgur.com/zurvYuI.jpg

"Maintenance and long-term expansion of murine skin epithelial stem cells by Wnt signalling pathway"

Wasn't this one of the major roadblocks that Koh-ei Toyoshima talked about in last year's interview with Organ Technologies? (See Question 1 of https://www.hairlosstalk.com/news/new-research/hair-primordiums-tsuji-organ-interview-sept2016/)

From the poster, it looks like they were able to multiply epithelial stem cells by 1000x while maintaining their hair inductive property. That's pretty cool. Here's hoping the same process can be used for human epithelial stem cells.

seems to be either a republication of this study from 2015 or an advancement with different methods that solved the shortcomings of the 2015 study. just based on face value, i suspect it is the latter because there are authors on the study from this year's whc in hellouser's picture that aren't in the 2015 study (kawai and sakagami), and the conclusion on the 2015 study states "Our results suggest the possibility of partial long-term maintenance of EpSCs in vitro by Wnt-3a" while the conclusion of the poster from this year's whc says "Our results suggest that EpSCs can be maintained in vitro in the presence of Wnt-3a"; the latter sounds much more definitive, like a confirmation of the 2015 study. this could be a huge hurdle of the tsuji roadblock

https://www.ncbi.nlm.nih.gov/pubmed/25437427

full article: http://sci-hub.io/10.1038/jid.2014.510

 

[Mitch Pelat]

great work Sir