Winlevi ( Cb 03 01 ) For Acne, Fda Approval

[Canuto]

I'd be interested in reading your "theory" on why a big dose of CB could potentially outnumber all circulating androgens.

It's not my "theory". There are at least 40 years of data on AR antagonist and agonists for the treatment of prostate cancer (which is not trigger by androgens anyway).
If what you claim was true, nilutamide, flutamide, bicalutamide and CPA wouldn't have made it to the market ever.

 

[Mustang]

Neither do I and I dosed finasteride up to 5mg a day before. But if I take even 0.05mg of dutasteride (1/10th the normal dose, which is 0.5mg) I feel my libido decrease. I'm just curious to see if Cialis will help me combat the side effects of dutasteride because 0.5mg makes me feel castrated for a week.

It's not my "theory". There are at least 40 years of data on AR antagonist and agonists for the treatment of prostate cancer (which is not trigger by androgens anyway).
If what you claim was true, nilutamide, flutamide, bicalutamide and CPA wouldn't have made it to the market ever.

What have I claimed?

 

[Canuto]

What have I claimed?

CB can't be use as monotherapy, you still need to inhibit DHT. It's got a weak binding affinity compared to DHT but it can potentially compete with Test.

This.

 

[Mustang]

I see.
So you believe a high enough dose would make it viable as a monotherapy without the need of blocking DHT.

According to the official reports it's not. I guess we will have to give it a try.

 

[Canuto]

I see.
So you believe a high enough dose would make it viable as a monotherapy without the need of blocking DHT.

According to the official reports it's not. I guess we will have to give it a try.

I don't have the answer because we don't have enough data, hence why I'm not using it as a monotherapy.
We know that RU58841 is 40 times stronger than CB (same affinity for the AR as testosterone, while CB is 1/40 of testosterone).
Some people reports success with RU alone, some don't. So if you use 2 ml of 7.5% of CB, you are using 3 times the dose that's usually being used with RU, while the difference in AR binding is 40 times less than RU.
Just based on plain math you will need way more, yet the first months of CB on trials looked promising. There could be a synergistic effect with CB helping with inflammation, due to its corticosteroid metabolite, but it's pure speculation at the moment.
On top of that, you have the possible AR upregulation both with RU and CB.
So we are still shooting in the dark. You are safer stacking things up as I have always said.

P.S.: Cassiopea is marketing it as an alternative to finasteride, not a complementary treatment, so I'm really curious to see how they will justify that on studies regarding the DHT inhibition.

 

[Mustang]

RU58841 by itself is not as effective as RU+finasteride.
Below some readings of circulating androgens from Kevin.

Scalp DHT on Finasteride+RU58841: 0.63 pmol/g

Scalp DHT with no treatments: 6.49 pmol/g

Serum DHT Finasteride+RU58841: 324 pg/ml

Serum DHT with no treatments: 645 pg/ml

Scalp DHT on Topical Dutasteride: 1,74 pmol/g

Serum DHT on Topical Dutasteride: 512 pg/ml

You could probably have less than 0.50 pmol/g scalp DHT while having the same (512 pg/ml) serum DHT if using Topical Dutasteride + RU58841

 

[Canuto]

RU58841 by itself is not as effective as RU+finasteride.
Below some readings of circulating androgens from Kevin.

Scalp DHT on Finasteride+RU58841: 0.63 pmol/g

Scalp DHT with no treatments: 6.49 pmol/g

Serum DHT Finasteride+RU58841: 324 pg/ml

Serum DHT with no treatments: 645 pg/ml

Scalp DHT on Topical Dutasteride: 1,74 pmol/g

Serum DHT on Topical Dutasteride: 512 pg/ml

You could probably have less than 0.50 pmol/g scalp DHT while having the same (512 pg/ml) serum DHT if using Topical Dutasteride + RU58841

I know, he posted them in the Discord channel and I've pinned them in the blood work section.
I'm speculating RU may work through other means that we are no aware of, since his DHT scalp inhibition with oral finasteride alone was 62%, while when stacked with RU went up to 91%.

P.S.: why do you refer to him as Kevin?

 

[jamesbooker1975]

Hey what kind of blood work should i be getting to test if it is shutting down and how often would you recommend i do so? I will be starting cb soon and after reading thr threat and looking at the study i am a little spooked, so want to keep an eye on it.

You need to check for LH and FSH . Best is to check it before start it , and then after a month of daily use. I will check it, the first year, every 6 month .

 

[jamesbooker1975]

RU58841 by itself is not as effective as RU+finasteride.
Below some readings of circulating androgens from Kevin.

Scalp DHT on Finasteride+RU58841: 0.63 pmol/g

Scalp DHT with no treatments: 6.49 pmol/g

Serum DHT Finasteride+RU58841: 324 pg/ml

Serum DHT with no treatments: 645 pg/ml

Scalp DHT on Topical Dutasteride: 1,74 pmol/g

Serum DHT on Topical Dutasteride: 512 pg/ml

You could probably have less than 0.50 pmol/g scalp DHT while having the same (512 pg/ml) serum DHT if using Topical Dutasteride + RU58841

But, Ru will not lower, or it should not lower the DHT, just block the receptor. And that should be the real goal, the DEFINITIVE treatment should be an antiandrogen blocker, that will not alter the DHT level, just block their " site " , and that can be easily check it if it is going systemic or not .

 

[Canuto]

You need to check for LH and FSH . Best is to check it before start it , and then after a month of daily use. I will check it, the first year, every 6 month .

If you have the money, I would check all the sex hormones and the adrenals function (DHEA-S and cortisol) prior to starting.

 

[Canuto]

But, Ru will not lower, or it should not lower the DHT, just block the receptor. And that should be the real goal, the DEFINITIVE treatment should be an antiandrogen blocker, that will not alter the DHT level, just block their " site " , and that can be easily check it if it is going systemic or not .

That's what we all knew, but if this gets confirmed by someone else scalp biopsy, it means we don't have the whole pharmacokinetic picture of RU.

 

[jamesbooker1975]

I don't have the answer because we don't have enough data, hence why I'm not using it as a monotherapy.
We know that RU58841 is 40 times stronger than CB (same affinity for the AR as testosterone, while CB is 1/40 of testosterone).
Some people reports success with RU alone, some don't. So if you use 2 ml of 7.5% of CB, you are using 3 times the dose that's usually being used with RU, while the difference in AR binding is 40 times less than RU.
Just based on plain math you will need way more, yet the first months of CB on trials looked promising. There could be a synergistic effect with CB helping with inflammation, due to its corticosteroid metabolite, but it's pure speculation at the moment.
On top of that, you have the possible AR upregulation both with RU and CB.
So we are still shooting in the dark. You are safer stacking things up as I have always said.

P.S.: Cassiopea is marketing it as an alternative to finasteride, not a complementary treatment, so I'm really curious to see how they will justify that on studies regarding the DHT inhibition.

Problem is that we have no idea if RU go systemic or not. PLus, it is home made in some China lab.

 

[jamesbooker1975]

That's what we all knew, but if this gets confirmed by someone else scalp biopsy, it means we don't have the whole pharmacokinetic picture of RU.

Think is, it is real RU ? that is the mean problem here. We are consider that a home made lab in China is selling online real RU . IN fact, if I apply RU and lower my DHT i will wonder, it is real RU ?

 

[Mustang]

I've checked my DHEA and Cortisol numbers a few weeks ago.

I might start applying 1% CB next week daily. Just need to source a local vehicle with no water.

 

[Dalcounter]

RU58841 by itself is not as effective as RU+finasteride.
Below some readings of circulating androgens from Kevin.

Scalp DHT on Finasteride+RU58841: 0.63 pmol/g

Scalp DHT with no treatments: 6.49 pmol/g

Serum DHT Finasteride+RU58841: 324 pg/ml

Serum DHT with no treatments: 645 pg/ml

Scalp DHT on Topical Dutasteride: 1,74 pmol/g

Serum DHT on Topical Dutasteride: 512 pg/ml

You could probably have less than 0.50 pmol/g scalp DHT while having the same (512 pg/ml) serum DHT if using Topical Dutasteride + RU58841

Very f*****g interesting .But with only finasteride scalp dht ?

 

[Equal Rights]

Problem is that we have no idea if RU go systemic or not. PLus, it is home made in some China lab.

From what i understand, it does go systemic. If it didn't people wouldn't get ED from it, but as we know almost everyone gets it at a certain dose.

 

[Jimmerson]

RU58841 by itself is not as effective as RU+finasteride.
Below some readings of circulating androgens from Kevin.

Scalp DHT on Finasteride+RU58841: 0.63 pmol/g

Scalp DHT with no treatments: 6.49 pmol/g

Serum DHT Finasteride+RU58841: 324 pg/ml

Serum DHT with no treatments: 645 pg/ml

Scalp DHT on Topical Dutasteride: 1,74 pmol/g

Serum DHT on Topical Dutasteride: 512 pg/ml

You could probably have less than 0.50 pmol/g scalp DHT while having the same (512 pg/ml) serum DHT if using Topical Dutasteride + RU58841

Anyone know what the dosage and formulation of the topical dutasteride is? Or where he's getting it? Would love to see it with topical finasteride

 

[jamesbooker1975]

Anyone know what the dosage and formulation of the topical dutasteride is? Or where he's getting it? Would love to see it with topical finasteride

there are a couple real pharmacies that compound it and even sell it online, I recommned doing that way. Lets face it, when you get something actually illegal from China, you can be sure what you are really getting . China is to shady about controls of real meds, chemical , etc.

 

[Canuto]

Very f*****g interesting .But with only finasteride scalp dht ?

I wrote it already. It was 62%.

 

[Canuto]

I've checked my DHEA and Cortisol numbers a few weeks ago.

I might start applying 1% CB next week daily. Just need to source a local vehicle with no water.

Cassiopea's CB was dissolved in a standard PG+ethanol+distilled water solution if I'm not wrong. I'm using it with Trichosol that has water and I don't have any problem with that.

You didn't respond to my former question. You took those number from a Spanish user, but I'm wondering why you call him Kevin.