Although I'm not convinced of the direct link between pdg2 and calcification as the text i've coped states, I wholeheartedly believe that calcification inhibits regrowth even with chems. And I have done so for years.
Unfortunately you mention this and mention related stuff such as 'blood flow' and people feel they are being transported back to the dark ages and refuse to re-look at the subject. However I believe this somewhat explains the three year window 'rule' that is often bandied around. Considering the limited chemicals and knowledge that was around at the time there is a legitimate reason why this theory fell by the wayside. .
This might also explain legitimately why seti/ and modern chems are not working AS WELL AS THEY SHOULD. They are (I believe) just parts of a larger jigsaw that needs to be addressed. I say again calcification is HUGE AND NEEDS TO BE RE-EXAMINED AND ADDRESSED
OPINIONS???
https://perfecthairhealth.com/prost...scovery-or-just-another-sign-of-inflammation/
text below in quotes partially taken from an interesting blog
PGD2 Hair Loss Forum Testers… Not Much (If Any) Regrowth
Some testers are reporting an arrest in hair loss. But unfortunately, none are showing significant signs of regrowth… even after a full year of testing.
But it’s not all bad news.
The Silver Lining: PGD2 Inhibitors + PGE2 Promoters Might Regrow Hair
Some researchers have combined PGD2 receptor blockers with PGE2 promoting substances, and with much better success.
Just check out the regrowth results from Swiss Temples. His “prostaglandin protocol” seems like a bit over-the-top – especially with the safety concerns of some of the substances. But it’s reaping results.
These anecdotes suggest that a PGD2 inhibitor + PGE2 promoter is probably better for hair regrowth, especially versus a PGD2 blocker alone. But based on radio silence from the PGD2 trials and the lacking results from others’ anecdotes – it seems like a PGD2 blocker alone isn’t going to regrow much hair.
Why Aren’t PGD2 Inhibitors Regrowing Much Hair?
While research is still ongoing, it might have to do with that question researchers never answered…
How exactly does prostaglandin D2 cause hair loss?
Maybe the answer is that prostaglandin D2 induces something else… calcification.
Prostaglandin D2 Doesn’t Just Trigger Hair Loss… It Also Triggers Calcification
Calcification is the build-up of calcium deposits in tissues where it doesn’t belong (for example, our soft tissues or our arteries). And studies show that PGD2 is a calcification inducer – meaning that PGD2 triggers calcification.
The bottom line: wherever PGD2 over-expresses, calcification may soon follow.
Calcification Is A Chronic Progressive Condition
The causes of calcification are complex, multifaceted, and not fully understood. But the important takeaway is this:
Calcification is chronic and progressive. If you take away whatever triggers calcification (for example, PGD2), you might stop more calcification from accumulating, but you likely won’t remove the calcification already present.
Scalp Calcification Precedes Hair Loss
The connection between calcification and hair loss was made over 70 years ago when researchers observed in those who were bald, the blood vessels supporting those dormant follicles had become completely calcified.
In fact, calcification precedes hair loss. Calcium buildup in our blood vessels restrict blood flow to our hair follicles, which reduces oxygen and nutrient flow to the follicles. This causes the hair to slowly shrink, until it disappears entirely.
Due To Calcification, PGD2 Inhibitors May Only Stop Hair Loss, But Not Regrow Much Hair
Remember: researchers haven’t yet uncovered exactly how PGD2 causes hair loss. Based on the evidence, my guess is this:
PGD2 induces calcification. That calcification then restricts blood flow to our follicles, until the follicle shrinks and the hair disappears.
If this is true, then it makes perfect sense why a PGD2 inhibitor may only stop future hair loss. If we block PGD2, we prevent future calcification… But we never get rid of the calcification that’s already there.
Why We Should Still Try To Reduce PGD2
It’s still in our best interest to decrease PGD2 expression. Doing so may protect us from hair loss and reduce the symptoms of allergies (and even asthma).
So, is there any way we can go about doing this naturally? Without drugs that haven’t completed the rigor of human trials?
Yes.
