What is the verdict on hairloss? Blood flow or genetics?

[Esquire Janey]

Epigenetic changes could possibly impact and either improve or worsen baldness. As a practical matter, it is all but entirely based upon genetics. I have seen identical twin pics who differ somewhat in the stage of baldness but that's not that common. If one identical twin goes skin bald then the other one has a phenomenally high probability of also being completely bald. Penis size might be similar in this aspect.

Under this reasoning, however, estradiol appears to be able to invoke enormous change in things previously dominated by male receptors. Thus, estradiol epigenetically turns off the male baldness gene, but this occurs along with every single indicia of masculinity from head to toe, especially the breasts and genitalia immediately changing tissue composition. Men and women's skin per se differs enormously and the skin changes come all but immediately. The hair is the least responsive thing to HRT for many people which might mean that balding areas have enormous numbers of hair receptors to which androgens tightly cling. It could take a decade or longer for long-term estradiol use to reverse baldness, the most prominent form of sexual dimorphism among humans I expect.

 

[Esquire Janey]

Scalp tension, mainly due to tight muscles surrounding galea and less blood PRESSURE to get through ( yes the scalp has loads of blood if you cut it, this disproves nothing ) inflammation then DHT then hair loss follow in that order.

So basically your galea is injured and inflamed under the skin as it's being pulled down by tight muscles around the sides. There is less blood pressure on route to galea hair follicles malloclusion may play a part here also.

Like anywhere on the body, DHT arrives at the site of inflammation. It's a simple google to confirm this well studied fact. it's no different with the scalp, hence hair loss.

At this stage I'm staggered most people think it's down to genetics, unless of course that's the genetics of having a huge galea, poor posture, mouth breather, tight temporalis or whatever is the main culprit for someone's tight scalp.

But the arguement that some people have some specific hair that is prone to attack from DHT, is 'genetics' is bonkers. It doesn't half make a lot of money though.

But DHT specifically promotes hair growth in most mammals so something fascinating is happening. So call it what one may, DHT appears to be very highly associated with turning off scalp hair growth in XY's while promoting beard growth and body hair growth. I don't deny your theory at all in terms of etiology but the circular question is why doesn't this happen to most white females and practically no Asian or Native American females? But regardless as to whether DHT is really a healing factor, the only thing that seems to cure the follicle is not DHT or T. It's estradiol.

 

[Ĺawton]

How is it that a follicle transplanted to an area of the head with all these problems can still grow?

The whole supporting area is transplanted. That is why transplants will usually hold up good for a couple of years at least.

I think what they love to call DHT sensitivity is just DHT parking itself there reacting to inflammation. I guess genetics may have some people react to it more strongly with DHT but the level of inflammation signaling is probably the biggest factor.

 

[Jakejr]

It’s both.. A genetic adaptation to encourage breeding at the height of hair expression..which is in youth.. And this genetic adaptation also lessens blood flow… Yes if we were female our hair would be growing like crazy..but of course we’re not..

 

[Ĺawton]

It’s both.. A genetic adaptation to encourage breeding at the height of hair expression..which is in youth.. And this genetic adaptation also lessens blood flow… Yes if we were female our hair would be growing like crazy..but of course we’re not..

I am pretty big with keeping up with anti-aging research and I am in the camp now that nature doesnt give a crap about you much when you are past prime reproductive age and might be purposely making the senescence ramp up after that period or at the least doesnt care at all so it allows the hyperfunction of cytokines etc then instead of trying to keep things in balance better. Heck they have shown in mice flooding old ones with young extracellular vesicles (even human ones) rejuvenates thèm a lot. Their mitochondria was almost correcting back to the statè of young mice. You also have somè non-mammals that only have pretty short periods of senescence prior to death from old age like crocodiles and turtles. I wonder what causes that. They dont suffer the very high senescent cell burden we do pòssiblÿ as theÿ age?

 

[Jakejr]

I think you’re on to something..
I’ve watched many videos of health fanatics & hair growth fanatics.. Recently one guy proposed mitochondria “pollution” my word.. as a serious energy as well as hair problem.. He went on to list best supplements & research..
Some I have never heard of.. So of course I went out & got them to clean out my mitochondria… I have a couple now & expecting an Amazon order today. I’ll stack ‘em all together & see what happens.. I’m already seeing some hair thickening ..

 

[Ĺawton]

I think you’re on to something..
I’ve watched many videos of health fanatics & hair growth fanatics.. Recently one guy proposed mitochondria “pollution” my word.. as a serious energy as well as hair problem.. He went on to list best supplements & research..
Some I have never heard of.. So of course I went out & got them to clean out my mitochondria… I have a couple now & expecting an Amazon order today. I’ll stack ‘em all together & see what happens.. I’m already seeing some hair thickening ..

Yep I think mitochondria decline is big in male pattern baldness with guys that are 30s and up at least and had a lot of their hair in their 20s. That stuff I am doing now is basically repairing mitochondria besìdes stimulating the stem cells if you find the rare artìcle that goes deeper on it. Its ramping up pgc-1a in the follicles which is maybe the biggest thing for keeping mitochondria healthy.

 

[Jakejr]

What supplements are you taking?

 

[Ĺawton]

What supplements are you taking?

A lot. Besides stàndard minerals and vitamins like magnesium and K2 i take MSM, Calcium AKG, Taurine and I rotate Niacin and Niacinamide. They recently discovered high P5P B6 and high Niacinamide after a workout stimulate muscle cell differentiation by a lot in older people and I definitely see the difference in gains at my age.

 

[Jakejr]

NMN..spermicide… TMG…carnosine..methylene blue

 

[Ĺawton]

NMN..spermicide… TMG…carnosine..methylene blue

What was interesting was NMN and NR with high dose P5P B6 after working out didnt increase muscle stem cell differentiation like niacinamide did. They speculated even though NMN and NR convert to NAM in the body that it having to be converted was somehow reducing the effect but said they had no 100% answer why that was the case