What are your thoughts on UCLA PP405? Do you think it is promising?

[papasmurfwashere]

This article is a long read, so you can skip to the end for the conclusion. In short, these aren't the droids you're looking for. Link is broken

htt ps:/ /medium.com/ @hairypapasmurf/pp405-the-good-the-bad-and-the-ugly-415cbef50894

 

[jondoeuk]

From Kintor Pharma: ''KT-215 is a topical MPC inhibitor under development by the Company. It activates hair follicle stem cells for Androgenetic Alopecia treatment. The mitochondrial pyruvate carrier (MPC) is located in the inner mitochondrial membrane. Studies have shown that when MPC is inhibited by drugs, pyruvate in the cytoplasm cannot enter the mitochondria, thereby increasing LDH (lactate dehydrogenase) activity and activating hair follicle stem cells, ultimately promoting hair growth. MPC has currently been proven to be a highly promising therapeutic target in the field of hair loss. The MPC inhibitor has identified a preclinical candidate compound (PCC) and preclinical research is currently underway for the treatment of Androgenetic Alopecia.''

 

[jondoeuk]

Pelage sent out an email: ''We are excited to provide a brief update on the clinical trials you signed up to hear about through our registry for androgenetic alopecia (pattern hair loss).

Male study

The AWAKEN clinical trial for men with androgenetic alopecia (Androgenetic Alopecia) is on track to launch this fall. Once the study is live, if you are located in one of the geographies where it’s recruiting, we will reach out directly with next steps, including how to see if you may be eligible to enroll.'' https://pelagepharma.com/

 

[Modill]

This is the most interesting product in decades. It doesn’t mess with hormones or testosterone, and it revives dead/dormant hair follicles without surgery.

It’s so promising that two different companies are developing different molecules based on the same mechanism of action.

The only issue I see is the usual one: if this compound enters the bloodstream and affects mitochondria throughout the body, we could be looking at some serious side effects.

 

[jondoeuk]

Triple Hair (Canada) began Phase 3 clinical trials for its Therapy-07 (THO7) topical in Vancouver, Canada, It contains minoxidil, finasteride and latanoprost. This product is already available for sale via prescription.

However, in August, Triple Hair released an updated pipeline on its Instagram. It says that the company was working on an MPC inhibitor called TH65 to treat Androgenetic Alopecia.

 

[Modill]

I found another company working on new MPC inhibitor. In total we have 5 companies doing this:

Pelage → PP405
Kintor → KT-215
Triple Hair → TH65
Shanghai Institute → SIPI11594 + otras series MPC

Interesting

 

[MrJolly26]

And who´s ahead in the game right now?

Still waiting, though 2026 is about to end in no time.

Hopefully 2027 will be a much better year with regard to news and new information about possible treatments.

 

[Modill]

And who´s ahead in the game right now?

Still waiting, though 2026 is about to end in no time.

Hopefully 2027 will be a much better year with regard to news and new information about possible treatments.

Pelage is starting phase 3. In 2027-2028 they will release it.
In fact, they are recruiting people if you want to join the study: https://pelagepp405.com/