cloudsanrain
Established Member
- Reaction score
- 112
Where on the internet sells it ?
What are your thoughts on UCLA PP405? Do you think it is promising?
- Thread starter fronty
- Start date
Sorry I misunderstood with 2-deoxy-D-ribose (2-desoxi-D-ribosa)
- Reaction score
- 3,430
All you need to do is to kill those damn demodex mites. You dont need any other treatment you loser.
- Reaction score
- 190
What about SMP?
UCLA is trying to blame Trump for this stuff being slow to make it to the market even though there is a private company website for the stuff that says its still in stage 2 trials. Stage 3 starting possibly later this year.
This stuff if it works is basically just doing what the Taiwan researchers stuff supposedly does but it uses lactate to switch the hairs back on. I mean these 2 things could be game changers for some hair loss especially people that haven't reached Norwood 5 if it can actually make the shrunken follicle return to its normal size over time. The real big test is can either of these 2 things over a long period get the stem cells to create new hair where the follicle doesn't even exist anymore. They have shown recently that those stem cells are still there in the skin even after many years of the follicles being gone. It has been shown already severe burns can make those stem cells create new hair.
Last edited:
Definitely not Brotzu 2.0.
PP405 is developped by UCLA and the science behind it is solid. It seems the Taiwan treatment works in a similar way.
Just a quick summary:
PP405 is developped by UCLA and the science behind it is solid. It seems the Taiwan treatment works in a similar way.
Just a quick summary:
- Mechanism: It shifts follicle metabolism from mitochondrial respiration to glycolysis, forcing stem cells to re-enter the growth phase.
- Clinical Trials: Positive Phase 2a trial results in 2024 showed 31% of men experienced >20% increased hair density.
- Usage: It is applied topically to the scalp once daily.
- Availability: Currently in development, with Phase 3 trials planned for 2026; FDA approval could potentially be as early as 2028.
Everything you need to know about PP405:
www.advancedhair.com
What is PP405: A Promising Hair Loss Solution—But Not Yet
PP405 is a hair loss solution that may help early-stage hair loss—but it’s not available today. Learn what PP405 is and how it compares to other solutions.
www.advancedhair.com
- Reaction score
- 1,062
That's right, stem cells remain in the scalp even after hair loss. This makes sense because the scalp continues to regenerate, and these are the same stem cells that are already present. So we can question the benefit of adding MORE stem cells.
- Reaction score
- 126
So it works on only 31 percent of users? Talk about worthless.
I think 31% had 20% + gains after 8 weeks but I read they were using people that had big balding areas also like severe NW4s. My guess is this like the fatty acids is probably the best for reviving dormant follicles if the area is still good enough to allow hair growth.
- Reaction score
- 2
What the hell happened to this?
- Reaction score
- 1
PP405 definitely shows promise but I wouldn’t call It the “miracle hair growth treatment” it’s being marketed as online. Phase II trials are complete but phase III is where it’ll show whether or not It can compete with current FDA approved treatments. Unfortunately, It works by reactivating dormant (sleeping) follicles, so It still requires follicles to work. In other words, individuals with progressive hair loss where follicles have “died” likely won’t show any additional benefit from this than other available treatments and would still require hair transplantation for definitive treatment. Hope this helps you with future planning!
If it's like the fatty acids which works the same way it could save follicles where no hair has been seen for 5 years. That was my result. That 2 year number they throw around isn't accurate. The little vertex spot I haven't had hair there for about 10 years it didn't save though.
- Reaction score
- 1
There is a company that has formulated PP405. The price isn't too high, but the big problem is its safety.
- Reaction score
- 5
It is one of the more interesting things in the pipeline, and worth following, but I would temper the excitement with a few honest caveats.
What makes it interesting is the mechanism. Finasteride slows loss and minoxidil thickens what is already there. PP405 is trying to do something neither of those does, which is to reactivate dormant follicles and grow new hair from units that had gone quiet.
If that holds up at scale, it is a genuinely different category of treatment rather than another variation on what we already have. The caution is in the data. The figure people quote, around a third of men with heavier loss seeing a meaningful density increase, comes from a small, short trial whose main purpose was safety rather than efficacy.
Four weeks of dosing, fewer than eighty people, and the strongest result sits in a subgroup rather than across everyone. That is an encouraging early signal, not proof. Phase 3 is where a lot of promising hair compounds have quietly failed to replicate, so the real test is still ahead.
There is also the timeline. Even on the optimistic path, Phase 3 only begins this year, which means years before it could realistically be available, if it succeeds at all. And we still do not know the durability, whether results hold without continued use, or how the effect looks once it meets the real world rather than a controlled trial.
So, cautiously promising. Worth watching closely. I would not put any current plans on hold waiting for it, and I would still treat the proven options as the baseline. But of the things in development, it is one of the few aimed at a real gap rather than a marginal improvement, and that is why it is getting the attention it is.
What makes it interesting is the mechanism. Finasteride slows loss and minoxidil thickens what is already there. PP405 is trying to do something neither of those does, which is to reactivate dormant follicles and grow new hair from units that had gone quiet.
If that holds up at scale, it is a genuinely different category of treatment rather than another variation on what we already have. The caution is in the data. The figure people quote, around a third of men with heavier loss seeing a meaningful density increase, comes from a small, short trial whose main purpose was safety rather than efficacy.
Four weeks of dosing, fewer than eighty people, and the strongest result sits in a subgroup rather than across everyone. That is an encouraging early signal, not proof. Phase 3 is where a lot of promising hair compounds have quietly failed to replicate, so the real test is still ahead.
There is also the timeline. Even on the optimistic path, Phase 3 only begins this year, which means years before it could realistically be available, if it succeeds at all. And we still do not know the durability, whether results hold without continued use, or how the effect looks once it meets the real world rather than a controlled trial.
So, cautiously promising. Worth watching closely. I would not put any current plans on hold waiting for it, and I would still treat the proven options as the baseline. But of the things in development, it is one of the few aimed at a real gap rather than a marginal improvement, and that is why it is getting the attention it is.