What are your thoughts on UCLA PP405? Do you think it is promising?

[cloudsanrain]

Where on the internet sells it ?

 

[Modill]

Where on the internet sells it ?

Sorry I misunderstood with 2-deoxy-D-ribose (2-desoxi-D-ribosa)

 

[losingbattle88]

Sorry I misunderstood with 2-deoxy-D-ribose (2-desoxi-D-ribosa)

All you need to do is to kill those damn demodex mites. You dont need any other treatment you loser.

 

[MrJolly26]

Still no news? About to reach 2026 and here we are

 

[Renovation]

Depends on your age.

If you are over 40 then I would wait. If you are 30 then I wouldn't. You are still relatively young and could have a shot with getting intimate partners who aren't single moms. There is only a 5% chance this drug actually works. You willing to risk waiting on that for nothing?

That being said. Be sure your surgeon is really good. I went to a really good surgeon and he rejected me and said my balding was too severe for surgery. So for me, all i can do is wait for a cure before I can get this fixed and be even remotely dateable.

What about SMP?

 

[Ĺawton]

Still no news? About to reach 2026 and here we are

UCLA is trying to blame Trump for this stuff being slow to make it to the market even though there is a private company website for the stuff that says its still in stage 2 trials. Stage 3 starting possibly later this year.

This stuff if it works is basically just doing what the Taiwan researchers stuff supposedly does but it uses lactate to switch the hairs back on. I mean these 2 things could be game changers for some hair loss especially people that haven't reached Norwood 5 if it can actually make the shrunken follicle return to its normal size over time. The real big test is can either of these 2 things over a long period get the stem cells to create new hair where the follicle doesn't even exist anymore. They have shown recently that those stem cells are still there in the skin even after many years of the follicles being gone. It has been shown already severe burns can make those stem cells create new hair.

 

[MrJolly26]

Let´s hope it will work, cause we don´t want a new Brotzu.

Thanks!

 

[Mr White]

Definitely not Brotzu 2.0.

PP405 is developped by UCLA and the science behind it is solid. It seems the Taiwan treatment works in a similar way.

Just a quick summary:

• Mechanism: It shifts follicle metabolism from mitochondrial respiration to glycolysis, forcing stem cells to re-enter the growth phase.
• Clinical Trials: Positive Phase 2a trial results in 2024 showed 31% of men experienced >20% increased hair density.
• Usage: It is applied topically to the scalp once daily.
• Availability: Currently in development, with Phase 3 trials planned for 2026; FDA approval could potentially be as early as 2028.

 

[Mr White]

Everything you need to know about PP405:

What is PP405: A Promising Hair Loss Solution—But Not Yet

PP405 is a hair loss solution that may help early-stage hair loss—but it’s not available today. Learn what PP405 is and how it compares to other solutions.

www.advancedhair.com

 

[Armando Jose]

They have shown recently that those stem cells are still there in the skin even after many years of the follicles being gone

That's right, stem cells remain in the scalp even after hair loss. This makes sense because the scalp continues to regenerate, and these are the same stem cells that are already present. So we can question the benefit of adding MORE stem cells.

 

[It_is_over_for_nw7]

Definitely not Brotzu 2.0.

PP405 is developped by UCLA and the science behind it is solid. It seems the Taiwan treatment works in a similar way.

Just a quick summary:

• Mechanism: It shifts follicle metabolism from mitochondrial respiration to glycolysis, forcing stem cells to re-enter the growth phase.
• Clinical Trials: Positive Phase 2a trial results in 2024 showed 31% of men experienced >20% increased hair density.
• Usage: It is applied topically to the scalp once daily.
• Availability: Currently in development, with Phase 3 trials planned for 2026; FDA approval could potentially be as early as 2028.

So it works on only 31 percent of users? Talk about worthless.

 

[Ĺawton]

So it works on only 31 percent of users? Talk about worthless.

I think 31% had 20% + gains after 8 weeks but I read they were using people that had big balding areas also like severe NW4s. My guess is this like the fatty acids is probably the best for reviving dormant follicles if the area is still good enough to allow hair growth.