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We Now Have A Cb-03-01 Vehicle That Works

Discussion in 'New Research, Studies, and Technologies' started by Desmond_84, May 29, 2019.

  1. Desmond_84

    Desmond_84 Established Member

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    Hi guys. I have some really exciting news to share.

    We finally have a working vehicle for CB-03-01:):):)

    I’ve had some spare time over the last 2 months and finally got around to doing some research on the chemical properties of CB-03-01 and possible vehicles that would be suitable for it.

    I’m pretty sure everyone on this forum is on the same page about what features we want in an ideal vehicle. At the end of the day, if you are applying it to your scalp once or twice a day on an ongoing basis, it needs to be cosmetically elegant, non-irritating and actually absorbs into the hair shaft.

    So, after a lot of digging around, I was intrigued by a range of topical vehicles marketed at compounding pharmacies to use with their actives. It’s called TrichoConcept by Fagron. Out of the whole range, two really stood out to me, the TrichoOil and TrichoSol.

    So, I managed to get some samples from the company and did some testing and TrichoSol proved to be the best one out of the two. TrichoOil was way too oily and probably would make the thinning areas more see-through which is not what we want. TrichoSol on the other hand really impressed me. It was elegant and dried up instantly without making my hair look dry or thinner than it was.

    So, what is TrichoSol? Here is everything I could find on it:

    TrichoSol is a highly spreadable hydrophilic solution containing mineral salts of vegetable origin. I was surprised to find out, it actually managed to stimulate human fibroblasts proliferation in an in-vitro study all on its own! Here's the study if you want to look into it yourself:

    In Vitro Effects of the Phytocomplex TrichoTech on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10
    DOI: 10.4236/jcdsa.2017.71001

    It also has some incredible properties. Here's some to name a few:
    • Proven stability with water-soluble and liposoluble Actives (Minoxidil, finasteride and Dutasteride). All actives remained stable for 3 months when added to TrichoSol.
    • Non-irritating vehicle
    • Alcohol-free
    • Does not cause hair dryness
    • Provides a simplified method to prepare topical scalp formulations

    I then used the company's TrichoConcept Formulary as a guide to formulate my own CB-03-01 topical solution and it worked like a charm! Here is the formulation for a 100mL bottle:

    CB-03-01: 2-4 grams
    PEG-40 Hydrogenated Castor Oil: 3 grams
    Ethoxy Diglycol: 5 mL
    TrichoSol: qs 100 mL (Add enough to fill to volume)

    It's also not too expensive. 1 Liter costs around US$135 and should last you at least 6-9 months.

    In terms of ordering it, you might be able to ask your local compounding pharmacies and see if they are willing to sell it to you. I can always get everyone some if people are keen.

    Hope this is helpful everyone.

    Cheers,

    Des
     
  2. NorwoodGuardian

    NorwoodGuardian Established Member

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    Hello Desmond, I have to buy from you. How to pay you?
     
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  3. jumpingjackgazz

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  4. NotInmywatch

    NotInmywatch Established Member My Regimen

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    very interesting that you have not seen CB precipitation in a HYDROPHILIC vehicle, which is theoretically impossible
    but if you haven't seen clumps or powder at the bottom of the vessel and the transcutol seems to be enough then this should be ok.

    "It was elegant and dried up instantly " this is not necesarrily good because proper absorption takes time depending on the vehicle.
    remember minoxidil 4 hour requirement?

    thanks for your contribution!
     
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  5. noveau22

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    Hmm I'd like to try it and perhaps buy it from you if possible. Perhaps enough to last a month to see if it works for me or not.

    Did you actually notice less shedding etc...?
     
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  6. MeDK

    MeDK Established Member My Regimen

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    wouldn't you keep it all in the same units to maintain the relation to the different ingredients?
     
  7. CapiLarry

    CapiLarry Member

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    that's good work!

    not to hijack the thread at all - but is there conclusive evidence from users here that CB has made a cosmetic difference?
     
  8. disfiguredyoungman

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    It's not the first time this guy presents the perfect vehicle for CB, just saying...
     
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  9. MeDK

    MeDK Established Member My Regimen

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    are you saying that peoples homemade regiments isn't world class hair loss science ?! and on this forum ?!
     
  10. Michael1986

    Michael1986 Established Member My Regimen

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    I don't believe there is. Also, the results of the phase 2 CB (Breezula) 12-month trial were slightly disappointing. The efficacy of CB appeared to decrease considerably between 6 months and 12 months of usage.
     
  11. Left4bald

    Left4bald Established Member My Regimen

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    Thanks @Desmond_84 :)

    And ?? It's Desmond ! A great member who I followed since many years (bald truth talk). He is a pharmacist if I remember well, and yes he has already proposed a solution for CB, but like all researchers, he tries and find the solution! You ? what do you do for us ?
     
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  12. petersonKj

    petersonKj Senior Member My Regimen

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    but CB doesn't even work itself
     
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  13. MeDK

    MeDK Established Member My Regimen

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    if he is a pharmacist, why isn't his measurements more accurate? I would expect that to be quite basic for a pharmacist?

    2-4 grams, it might not seems at much when its so small measurements, but there is a difference factor 2 in difference, and then the weird units with volume and weight.

    why do one liquid in grams and the others in volume?
     
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  14. disfiguredyoungman

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    I am analyzing papers for the community so you don't buy snake oil such as Zinc-Thymulin. I think I am doing my part.I just find it a bit dubious that he is selling a flavor of the month vehicle every trimester or so.
     
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  15. kiwipilu

    kiwipilu Experienced Member My Regimen

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    that's not a big deal. mix all the first 3 ingredients in a measuring container and fill to 100ml. the only variable is CB ; 2-4 is minimal a range this "should potentially" work. obviously it also depends on what money people can spend. But he could have written 2 - 7,5grams(highest concentration in the trial and the most effective).
     
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  16. kiwi666

    kiwi666 Experienced Member My Regimen

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    What. A. Looser.
     
  17. whatevr

    whatevr Senior Member My Regimen

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    Anyone remember when it was this?

    https://www.b aldtruthtalk.com/threads/17682-We-have-a-vehicle-for-CB-03-01-VERSAPRO

    5 years ago people were talking about this shit. Five. Fucking. Years. What a joke.
     
  18. NotInmywatch

    NotInmywatch Established Member My Regimen

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    I think what OP is trying to convey is a cosmetically aceptable vehicle
    I concede that despite CB correctly working as expected, my dried up hair with ethanol looks horrible
    So, any improvement on that would be welcome.
     
  19. nonconformist

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    Can anyone give me your opinion if dutasteride with trichosol at 0.01% concentration would have systemic effects or due to the size of the dutasteride molecule would not it? I would appreciate any opinion, thank you.
     
  20. hilbert

    hilbert Established Member

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    nice work, but i'll go on with the vehicle in the patent: the local & systemic absorption rate and speed were measured (in vivo) with that. so play it safe.
     

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