Topical Finasteride The Most Important Question I Believe

[Badbald]

Hi all, Iv posted about this in and out between random threads a few times but I myself am still non the wiser to this as i thought i knew the answer but now im not sure so im calling on all you guys with the knowledge to help answer...

The question is: Does Finasteride work by blocking off an actual producer of the hormone DHT e.g the testes, a gland etc OR does it work by directly interacting with the dht itself to get rid of it, by some how binding with dht and destroying it?

I feel this is the key as to whether a topical would work or not, if it does effect the gland to make it stop producing the dht then its useless as it would have to go systematic in order to get to the gland and effect the entire body to work but if it effects the dht in the blood directly then it may very well work well.

So yeah anyone who knows the answer please reply i think its pretty important, thanks a lot.

 

[Alk]

No gland produces dht it produces test that turns into dht throu an enzyme 5 ar. And topical finasteride pretty much goes into ur system. Finasteride blocks the enzyme, thats how it works.

 

[Badbald]

Ok thanks yeah Iv just been reading into it more I think the question is tnot if it goes systematic because it probably will and it's going to be hard to stop that but can it work by binding to the testosterone locally in the scalp and if that is true then you may need a lower dose then a pill for it to work effectively.therefore reducing the sides and effects to the rest of your body, this could potentially be pretty big

 

[Alk]

No offense but this is nothing new and not a big find. finasteride binds to an enzyme not testosterone. Topical and oral finasteride pretty much both lower dht in the blood. If u want to take finasteride then try .25 mg and build up or stay at .25 mg.

 

[rclark]

Topical Finasteride preforms slightly better than oral Finasteride.

In general, .1% Topical = one milligram oral. In studies, it eliminates six percent
more DHT conversion than oral.

That said, they're both equal (topical is slightly better).

 

[Badbald]

Ok thanks people, yeah it would just make sense that the more efficient it is at effecting the scalp directly, the lower the dose you may need and therefore lower sides

 

[Badbald]

iv read the study

Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia

and it says "Conclusions: The novel finasteride 0.25% solution applied o.d. at the doses of 100 and 200 μL results in an appropriate inhibition of scalp DHT potentially minimizing the untoward sexual side-effects linked to a systemic DHT reduction."


Im not sure if this study has been discussed properly on here but surely this cant be ignored, it could be what alot of people are looking for, right?

 

[Alk]

Topical goes into ur system, the difference between topical and oral is literally only 2% and the connection to scalp dht, serum dht is still debated. Go on new research and look into the itallian topical, thats more what your looking for, its already been in the works. So no topical is not really reducing sides if you got sides from finasteride orally.

 

[hairblues]

Topical goes into ur system, the difference between topical and oral is literally only 2% and the connection to scalp dht, serum dht is still debated. Go on new research and look into the itallian topical, thats more what your looking for, its already been in the works. So no topical is not really reducing sides if you got sides from finasteride orally.

interesting i got sides from Oral spironolactone but not topical spironolactone

 

[Badbald]

Topical goes into ur system, the difference between topical and oral is literally only 2% and the connection to scalp dht, serum dht is still debated. Go on new research and look into the itallian topical, thats more what your looking for, its already been in the works. So no topical is not really reducing sides if you got sides from finasteride orally.

Thanks for that yeah iv been reading about the italian topical, im just so skeptical of anything until its out and working on the market iv been lurking on here for years now and it just seems like everytime it ends up that the big 3 are always coming out ontop of anything that looked promising to start with.

Back to the whole topical debate, if topicals effect your system the same way as orals why is it fine to use minoxidil as a topical but its meant to be dangerous as an oral? i understand thats meant to effect your blood pressure etc not the same as fins sides but i think that if this effects your system differently as a topical to an oral then theres an argument for finasteride to do the same when applied in small dose.

 

[Alk]

Thanks for that yeah iv been reading about the italian topical, im just so skeptical of anything until its out and working on the market iv been lurking on here for years now and it just seems like everytime it ends up that the big 3 are always coming out ontop of anything that looked promising to start with.

Back to the whole topical debate, if topicals effect your system the same way as orals why is it fine to use minoxidil as a topical but its meant to be dangerous as an oral? i understand thats meant to effect your blood pressure etc not the same as fins sides but i think that if this effects your system differently as a topical to an oral then theres an argument for finasteride to do the same when applied in small dose.

Yeah thats a good question. The truth is minoxidil does get into ur system. There was a study showing 2% minoxidil for six months statistically effects the size of your left ventricle. Now it was only statistically significant not really significant as a noticeable increase. But the study didnt have a followup so the conclusion was more studies needs to happen. But ppl have been taking it for 10+ years so that might put ppl at ease. As you stated thou minoxidil is not as dangerous topically because you are applying it to the skin and then it is being absorbed , by the time it goes systemic the amount being exposed to the blood stream must be very low, where as in finasteride a small amount in topical still lowers dht almost as much as 1-5mg so its still giving the same side as oral finasteride.hope that helps

 

[Alk]

interesting i got sides from Oral spironolactone but not topical spironolactone

Yeah in the case of finasteride there's a very low response curve.

 

[WereInaRecession]

Any hasson and wong topical liposomal finasteride users on here want to chime in. I'm trying to get my American doctor to prescribe it to me from that Italian compounding pharmacy. If I get it i have my baseline dht and ill retest it in few months after use to see how it does or doesnt affects systemically.

 

[spooon]

Good thread. University of Milan who I understand were involved in testing/formulating the H&W topical claim the sides are significantly reduced versus oral. Clearly this is all a question of degree. It would be interesting to know if anyone has any first hand experience of the success or lack thereof and side effect profile of the H&W topical. To say it's bound to go systemic is not satisfactory IMO.

 

[rclark]

Liquid Finasteride fights androgen alopecia slightly better than oral. It's only six percent
higher DHT.

Of course neither are better than Androvart. (dutasteride.).

There's really not much evidence that either is safer.