No, I meant what's the pathological reasoning in adding cetirizine to your hair loss regimen? What does it do? I'm not bashing, I'm just curious.Crush up cetirizine tablets and do 1 tablet per 1ml roughly, so mix it with water or a vehicle. So 60 tablets with 60ml of water mix it up. Leave it too settle over night then there will be the tablet filler at the bottom and liquid containing the cetirizine at the top. And you can either seperate the filler (I used coffee filters) or you can just draw off the top with pipte and leave the filler there. You apply 1ml to your head exactly the same as you would with minoxidil.
https://www.researchgate.net/public...r_loss_A_suggestive_implication_of_mast_cells
Dermal fibrosis in male pattern hair loss: A suggestive implication of mast cells
Abstract
A relationship has been suggested between mast cells (MCs) and male pattern hair loss (MPHL), because of histological evidence of perifollicular fibrosis and increased mast cell numbers. Two paired punch biopsies were taken from balding vertexes and non-balding occipital promontory areas of ten patients with MPHL (Ludwig-Hamilton IIIv to IV) and from five normal subjects aged from 20 to 35 years. Masson trichrome and Victoria blue staining were performed to observe collagen frameworks and elastic fiber structures. Numbers of immunoreactive MCs stained with anti-tryptase or anti-chymase antibody were counted. It was found that collagen bundles were significantly increased in balding vertexes than in non-balding occiput scalp skin. A near 4-fold increase in elastic fibers was observed in both vertex and occiput scalp skins with MPHL versus controls. Total numbers of MCs (tryptase-positive) in site-matched scalp samples were about 2-fold higher in MPHL subjects than in normal controls. Percentage elastic fiber (%) was found to be relatively well-correlated with tryptase and chymase-positive MCs. These findings suggest that accumulated MCs might be responsible for increased elastic fiber synthesis in MPHL, and indicate that future investigations are warranted.
J Cutan Pathol. 2014 Apr;41(4):364-9. doi: 10.1111/cup.12286. Epub 2014 Jan 20.
[h=1]A prostaglandin D-synthase-positive mast cell gradient characterizes scalp patterning.[/h]Larson AR1, Zhan Q, Johnson E, Fragoso AC, Wan M, Murphy GF.
[h=3]Author information[/h]
[h=3]Abstract[/h][h=4]BACKGROUND:[/h]Pattern (androgenetic) alopecia is commonly encountered in scalp biopsies obtained for non-scarring hair loss. Prostaglandin D-synthase is known to be elevated in bald vs. non-alopetic scalp of patients with androgenetic alopecia. We hypothesized that this difference in pattern of prostaglandin D-synthase expression may constitute a developmental pattern inherent to normal as well as alopecic scalp skin, thus defining a 'field' vulnerable to acquired hair loss.
[h=4]METHODS:[/h]We immunohistochemically mapped prostaglandin D-synthase expression from supra-auricular to vertex scalp skin of 11 cadavers.
[h=4]RESULTS:[/h]We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells.
[h=4]CONCLUSIONS:[/h]These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase distribution in a manner reminiscent of the pattern seen in androgenetic alopecia.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Where can I obtain this and how do I take it? What are the doses?setipiprant
What do you mean, how?Cetirizine can grow hair, but it has a negative effect on the quality of your hair. I advice you not to use it.