- Reaction score
- 96
http://www.sciencedirect.com/science/article/pii/S0022202X15529497
It's been known for a while that estrogen receptor activation can influence androgen receptor activity/quantity, but not until reading this paper did the connection really become clear to me. The most interesting part of this was the data that showed that Estrogen receptor beta (ER-b) is found in more parts of the pilosebacious unit than the androgen receptor is.
(paraphrasing) ER-b was found in the outer root sheathe, epithelial matrix, keratinocytes of the stratum basale and stratum spinosum, bulge, and the dermal papilla, whereas AR was only found in the dermal papilla.
So if it's clear that estrogen receptor modulation can affect androgen receptors, I wonder if it's also possible that androgen receptor modulation can in turn affect estrogen receptors; or if this is the actual effect that takes place when men use anti-androgens.
I was originally trying to find data showing which body tissues in men are found to possess the ER-b receptor, the primary (16x selectivity) receptor to S-equol. Interestingly, while this article is not that thorough at delivering on the subject of its title, it elaborates extensively on estrogen's receptor activity in the scalp and pilosebacious units. I'd still like to know which tissues would be affected by ER-b activation/S-equol, so if you have any good sources please share them.
I have to wonder if S-equol would be a better option for treating Androgenetic Alopecia than anti-androgens.
It's been known for a while that estrogen receptor activation can influence androgen receptor activity/quantity, but not until reading this paper did the connection really become clear to me. The most interesting part of this was the data that showed that Estrogen receptor beta (ER-b) is found in more parts of the pilosebacious unit than the androgen receptor is.
(paraphrasing) ER-b was found in the outer root sheathe, epithelial matrix, keratinocytes of the stratum basale and stratum spinosum, bulge, and the dermal papilla, whereas AR was only found in the dermal papilla.
So if it's clear that estrogen receptor modulation can affect androgen receptors, I wonder if it's also possible that androgen receptor modulation can in turn affect estrogen receptors; or if this is the actual effect that takes place when men use anti-androgens.
I was originally trying to find data showing which body tissues in men are found to possess the ER-b receptor, the primary (16x selectivity) receptor to S-equol. Interestingly, while this article is not that thorough at delivering on the subject of its title, it elaborates extensively on estrogen's receptor activity in the scalp and pilosebacious units. I'd still like to know which tissues would be affected by ER-b activation/S-equol, so if you have any good sources please share them.
I have to wonder if S-equol would be a better option for treating Androgenetic Alopecia than anti-androgens.
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