The Role Of 5 Alpha Reductase Type 1 In male pattern baldness

[shwareb]

Hey guys so as the title suggests I’m wondering whether 5 alpha reductase type 1 plays any role in male pattern baldness, because I read somewhere that there were these Dominican dudes that had a genetic deficiency in type 2, but normal type 1 and they never went bald. This suggests to me that it’s type 2 which is the enzyme responsible so then why is dutasteride which blocks both type 1 and 2 more effective than finasteride that only blocks type 2? Is Dutasteride better at blocking type 2 than finasteride, which would explain it? Also if this is the case why didn’t Merck try to find a better inhibitor than finasteride of type 2 only. Is it not possible to do that without blocking type 1 as well?

I am considering taking Dutasteride after being on finasteride for 5,5 months with no sides, but really I don’t like the idea of blocking type 1 if I don’t need to especially since it exits in significant quantities in the brain?

What do you guys think about this?

 

[AnxiousAndy]

Its possible those Dominican guys just weren't predisposed to male pattern baldness. Merck actually did trial run a drug which blocked type 1 and it didn't help with hair loss. Stick with finasteride, dutasteride is only for those who see no benefit from finasteride or have had finasteride stop working for them.

 

[abcdefg]

Hey guys so as the title suggests I’m wondering whether 5 alpha reductase type 1 plays any role in male pattern baldness, because I read somewhere that there were these Dominican dudes that had a genetic deficiency in type 2, but normal type 1 and they never went bald. This suggests to me that it’s type 2 which is the enzyme responsible so then why is dutasteride which blocks both type 1 and 2 more effective than finasteride that only blocks type 2? Is Dutasteride better at blocking type 2 than finasteride, which would explain it? Also if this is the case why didn’t Merck try to find a better inhibitor than finasteride of type 2 only. Is it not possible to do that without blocking type 1 as well?

I am considering taking Dutasteride after being on finasteride for 5,5 months with no sides, but really I don’t like the idea of blocking type 1 if I don’t need to especially since it exits in significant quantities in the brain?

What do you guys think about this?

Like the above said stick to finasteride its a lot safer. This has been discussed in the past you can search for bryan too he had answers around this. finasteride = 70 percent 5 ar 2. dutasteride = nearly 100 percent 5 ar 2. dutasteride is much more effective at reducing the 5 ar 2 which is why it works better, but 5 ar 1 like said above was not found to be a major player in male pattern baldness. Removing it is a bit dangerous and silly for no reason.
That being said dutasteride is stronger and works better, but I wouldnt touch the stuff personally. I think DHT generally and 5 ar 1 does have roles in the body we dont understand yet. A study found 5 ar 1 does play a role in insulin production. Just not worth the risks for hair.

 

[Marcoco]

Like the above said stick to finasteride its a lot safer. This has been discussed in the past you can search for bryan too he had answers around this. finasteride = 70 percent 5 ar 2. dutasteride = nearly 100 percent 5 ar 2. dutasteride is much more effective at reducing the 5 ar 2 which is why it works better, but 5 ar 1 like said above was not found to be a major player in male pattern baldness. Removing it is a bit dangerous and silly for no reason.
That being said dutasteride is stronger and works better, but I wouldnt touch the stuff personally. I think DHT generally and 5 ar 1 does have roles in the body we dont understand yet. A study found 5 ar 1 does play a role in insulin production. Just not worth the risks for hair.

Ive read a few things online about the dht reduction yes it is about 65 to 70% but what i dont understand is, is this its overall effect on lowering scalp dht which if i am correct is what causes baldess of is this spread over the body as ive read that it only lowers scalp dht to around 40% but then seen studies saying otherwise which has left me a bit confused as to how dht is targeted around the body and how much is left to potentially still cause harm.