- Reaction score
- 528
The basic concept to solving male pattern baldness is to stop androgen receptor binding to any androgen.
You can do this by:
shutting off your own androgen production
taking androgen receptor blockers
taking estrogen to offset the ratio of test vs estro receptor activation (not as effective)
taking DHT inhibitors to prevent DHT a very strong androgen from binding to the androgen receptor
BUT HERES THE WAY IT CAN ACTUALLY BE DONE WITH NO SEXUAL SIDE EFFECTS
SARMS
some SARMS have the ability to selectively bind to the androgen receptors in the bones and muscles but not to hair follicles or prostate cells. Some SARMS even have anti DHT characteristics. If selectively targeting the androgen receptors is possible in this way than the opposite must be true too.
If you can selectively target the androgen receptors in hair follicles and instead bind to them to turn them inactive instead of activating their gene expression you will stop male pattern baldness 100%. If this is achieved, hair regrowth that was never before possible will become possible.
Selectively targeting receptors is not rare. SERMS for example, Tamoxifen, targets breast tissue estrogen receptors much more so than any other other estro receptors in the body making it a very effective drug for breast cancer and so effective for bodybuilding use.
There are literally 10s if not 100s of other SARMS that specifically do not target the androgen receptors in the hair and prostate. All that needs to happen is for this to be reverse engineered so that it specifically targets hair androgen receptors and blocks them.
I dont as of now have the organic chemistry understanding to find out what differences in the chemical structure of these compounds cause them to target or not target specific areas but if anyone reading this does, you can make the drug that stops hairloss forever.
Structure of Testosterone:
Structure of Flutamide (androgen receptor blocker):
Stucture of Apalutamide (stronger androgen receptor blocker):
Structure of Ostarine (a SARM):
You can do this by:
shutting off your own androgen production
taking androgen receptor blockers
taking estrogen to offset the ratio of test vs estro receptor activation (not as effective)
taking DHT inhibitors to prevent DHT a very strong androgen from binding to the androgen receptor
BUT HERES THE WAY IT CAN ACTUALLY BE DONE WITH NO SEXUAL SIDE EFFECTS
SARMS
some SARMS have the ability to selectively bind to the androgen receptors in the bones and muscles but not to hair follicles or prostate cells. Some SARMS even have anti DHT characteristics. If selectively targeting the androgen receptors is possible in this way than the opposite must be true too.
If you can selectively target the androgen receptors in hair follicles and instead bind to them to turn them inactive instead of activating their gene expression you will stop male pattern baldness 100%. If this is achieved, hair regrowth that was never before possible will become possible.
Selectively targeting receptors is not rare. SERMS for example, Tamoxifen, targets breast tissue estrogen receptors much more so than any other other estro receptors in the body making it a very effective drug for breast cancer and so effective for bodybuilding use.
There are literally 10s if not 100s of other SARMS that specifically do not target the androgen receptors in the hair and prostate. All that needs to happen is for this to be reverse engineered so that it specifically targets hair androgen receptors and blocks them.
I dont as of now have the organic chemistry understanding to find out what differences in the chemical structure of these compounds cause them to target or not target specific areas but if anyone reading this does, you can make the drug that stops hairloss forever.
Structure of Testosterone:
Structure of Flutamide (androgen receptor blocker):
Stucture of Apalutamide (stronger androgen receptor blocker):
Structure of Ostarine (a SARM):