Regeneration of complex oral organs using 3D cell organization technology Happy new year and I wish you all the best because you deserve it Here, 3 days ago, a new article was published on Cell Differentiation and Development I uploaded the whole pdf (7 pages) for the curious lurkers " The development of organoid techniques for regenerative therapy has progressed remarkably with the use of tissue derived stem cells and pluripotent stem cells based on stem cell biology and tissue engineering technology. To realize whole-organ replacement therapy as next-generation regenerative medicine, it is expected that fully functional bioengineered organs can be reconstructed using an in vitro three-dimensional (3D) bioengineered organ germ and organoids by stem cell manipulation and self-organization. In this mini-review, we focused on substantial advances of 3Dbioengineering technologies for the regeneration of complex oral organs with the reconstruction of 3D bioengineered organ germ using organ-inductive potential embryo-derived epithelial and mesenchymal cells. These bioengineering technologies have the potential for realization of future organreplacement therapy ". Thus, it is desired to develop a next-generation regenerative approach in which fully functional bioengineered organs can be reconstructed using in vitro 3D stem cell manipulation and organization technology. 3D tissue organization and therapeutic potential by organoid technology. An organoid model, which refers to 3D tissue structures containing various functionally differentiated cells through self-organization from immature stem cells and isolated tissue fragments, is available for regenerative therapies through the replication of its tissue-specific stem cell niches. Organoid studies are divided into two major approaches, reconstitution of bioengi-neered organ germ using organ-inductive potential embryo-derived and/or adult-derived epithelial and mesenchymal stem cells and organoid induction, whichis repeated by organ induction processes during embryo genesis using pluripotent stem cells, including embryonictem cells (ES cells) and induced pluripotent stem cells (iPS cells). We have developed an organ germ method to reconstitute bioengineered organ germs  and demonstrated proof of concepts for functional organ regeneration by orthotopic transplantation of the bioengineered germs, including the tooth, salivary gland, lachrymal gland and hair follicles. This unique technology could achieve the precise replication of the developmental processes in organogenesis and organ-size regulation, adjusted by the cell-to-cell contact length between the epithelial and mesenchymal cell layers, thereby enabling the development of many types of bioengineered organ germs such as teeth, hair, salivary glands and lacrimal glands. In addition, notable recent research has demonstrated the bioengineered 3D integumentary organ system from iPS cells and includes appendage organs such as skin, hair follicles and sebaceous glands. This bioengineered 3D integumentary organ system also demonstrates the feasibility of available bioengineering technology in oral organs and the realization of whole-organ replacement therapy using iPS cells"