T-flavanone Improves The Male Pattern Of Hair Loss By Enhancing Hair-anchoring Strength: A Randomize | HairLossTalk Forums
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T-flavanone Improves The Male Pattern Of Hair Loss By Enhancing Hair-anchoring Strength: A Randomize

Discussion in 'Hair Loss and Alopecia Published Studies' started by Squeegee 2.0, Jul 12, 2019.

  1. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    Abstract
    Introduction
    trans-3,4′-Dimethyl-3-hydroxyflavanone (t-flavanone) is a derivative of astilbin that actively stimulates hair growth. The aim of the present study was to identify the mechanisms of action of t-flavanone on hair growth.

    Methods
    A double-blind usage test was performed with healthy volunteers who had androgenic alopecia (Androgenetic Alopecia). The subjects were divided into three groups with equal average baldness. The members in each group applied a vasodilator-containing hair lotion supplemented with either 0, 0.1, or 0.3% (wt) t-flavanone twice a day for 30 weeks. The efficacy of t-flavanone was evaluated based on the parietal global and microscopic images. At week 30, the anchoring strength of hair was measured by the average peak force required for plucking out a single hair in a non-bald area using a digital force gauge. Desmoglein expression in the cultured human hair follicle was analyzed by Western blotting.

    Results
    After 30 weeks, t-flavanone significantly improved Androgenetic Alopecia and enhanced the hair-anchoring strength in a hair diameter-independent manner. Culture of human hair follicles in vitro with t-flavanone resulted in the upregulation of desmoglein protein expression.

    Conclusions
    The results of our in vivo and in vitro studies demonstrated that t-flavanone enhanced the cell-cell adhesions in hair follicles; thus, reinforcement of hair rooting may be a mechanism by which t-flavanone promotes hair growth.


    https://link.springer.com/article/10.1007/s13555-016-0101-1
     
  2. zaman

    zaman Established Member My Regimen

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    Astilbin is found in Chinaroot which is referred to as Tu Fu Ling in traditional Chinese Medicine. One of its many uses is for 'heat' (inflammation) & 'toxicity' (infection) causing acne, boils, carbuncles and other skin conditions. You can purchase the liquid extract and alcohol-based tincture easily.
     
  3. whatevr

    whatevr Senior Member My Regimen

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  4. Mandar kumthekar

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    Not much improvement I could see. Useless.
     
  5. whatevr

    whatevr Senior Member My Regimen

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    LOL seriously dude, on a NW7 like that guy, he likely wouldn't even see any regrowth from Dutasteride. The fact that he had any regrowth from this especially on the front is impressive. o_O
     
    Squeegee 2.0 and Dat5Years like this.
  6. Dat5Years

    Dat5Years Established Member My Regimen

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    Are you serious?
     
  7. Dat5Years

    Dat5Years Established Member My Regimen

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    https://www.bristolbotanicals.co.uk/pr-1164
    like this?
     
  8. Mandar kumthekar

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    I can't see new hairs ,all I can see is existing hairs becomes thicker which I don't think a great accomplishment.
     
  9. hailbrotzu

    hailbrotzu Established Member My Regimen

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    Anyone going to try this? I might try it until celino comes out
     
  10. Dat5Years

    Dat5Years Established Member My Regimen

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    Yeah I will if the product I posted is correct its cheap as sh*t
     
  11. zaman

    zaman Established Member My Regimen

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  12. whatevr

    whatevr Senior Member My Regimen

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    image-01.jpg

    Astilbin and t-Flavanone are quite different from one another. I'm not sure why you're assuming they're interchangeable or that they will have similar effects. The difference between testosterone and estrogen - two functionally very different hormones - is a single methyl and hydroxyl group, and that's a far smaller difference than the one between these two.

    If you want to test the results from this study, you'll have to test t-flavanone. Buying some herb that contains something remotely similar to the chemical used in the study is a far reach.

    I bought the Sensai hair loss lotion which contains t-Flavanone and will start using it soon.
     
  13. Rzuty

    Rzuty New Member My Regimen

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    I also bought and just received the lotion. They also have a Sensai shampoo but with no t-flavanone (contrary to what was indicated on the German website where I bought it)...just piroctone olamine (better than nothing).
     
  14. Rzuty

    Rzuty New Member My Regimen

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    There is also the "Dualsenses Scalp Specialist by Goldwell Anti-Hairloss Spray 125ml" which has t-flavanone and is cheaper than the Sensai lotion.
     
  15. John Difool

    John Difool Experienced Member My Regimen

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  16. whatevr

    whatevr Senior Member My Regimen

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    Well, it smelled nice. That's about it. I went through the one bottle (lasted about 2 and a half months), didn't really get the impression that it was doing much.

    It's also insanely expensive for what it is (70 USD). You could buy a 6 month supply of minoxidil for that price.
     
    inmyhead likes this.
  17. John Difool

    John Difool Experienced Member My Regimen

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    Bummer. You seemed so jazzed up about it. Oh well... another one bytes he dust.
     
  18. Squeegee 2.0

    Squeegee 2.0 Established Member My Regimen

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    That guy gets it!^^^^
     
  19. whatevr

    whatevr Senior Member My Regimen

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    It usually do be like dat.
     

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