T-flavanone Improves The Male Pattern Of Hair Loss By Enhancing Hair-anchoring Strength: A Randomize | HairLossTalk Forums
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T-flavanone Improves The Male Pattern Of Hair Loss By Enhancing Hair-anchoring Strength: A Randomize

Discussion in 'Hair Loss and Alopecia Published Studies' started by Squeegee 2.0, Jul 12, 2019.

  1. Squeegee 2.0

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    Abstract
    Introduction
    trans-3,4′-Dimethyl-3-hydroxyflavanone (t-flavanone) is a derivative of astilbin that actively stimulates hair growth. The aim of the present study was to identify the mechanisms of action of t-flavanone on hair growth.

    Methods
    A double-blind usage test was performed with healthy volunteers who had androgenic alopecia (Androgenetic Alopecia). The subjects were divided into three groups with equal average baldness. The members in each group applied a vasodilator-containing hair lotion supplemented with either 0, 0.1, or 0.3% (wt) t-flavanone twice a day for 30 weeks. The efficacy of t-flavanone was evaluated based on the parietal global and microscopic images. At week 30, the anchoring strength of hair was measured by the average peak force required for plucking out a single hair in a non-bald area using a digital force gauge. Desmoglein expression in the cultured human hair follicle was analyzed by Western blotting.

    Results
    After 30 weeks, t-flavanone significantly improved Androgenetic Alopecia and enhanced the hair-anchoring strength in a hair diameter-independent manner. Culture of human hair follicles in vitro with t-flavanone resulted in the upregulation of desmoglein protein expression.

    Conclusions
    The results of our in vivo and in vitro studies demonstrated that t-flavanone enhanced the cell-cell adhesions in hair follicles; thus, reinforcement of hair rooting may be a mechanism by which t-flavanone promotes hair growth.


    https://link.springer.com/article/10.1007/s13555-016-0101-1
     
  2. zaman

    zaman Established Member My Regimen

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    Astilbin is found in Chinaroot which is referred to as Tu Fu Ling in traditional Chinese Medicine. One of its many uses is for 'heat' (inflammation) & 'toxicity' (infection) causing acne, boils, carbuncles and other skin conditions. You can purchase the liquid extract and alcohol-based tincture easily.
     
  3. whatevr

    whatevr Senior Member My Regimen

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  4. Mandar kumthekar

    Mandar kumthekar Experienced Member My Regimen

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    Not much improvement I could see. Useless.
     
  5. whatevr

    whatevr Senior Member My Regimen

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    LOL seriously dude, on a NW7 like that guy, he likely wouldn't even see any regrowth from Dutasteride. The fact that he had any regrowth from this especially on the front is impressive. o_O
     
    Dat5Years likes this.
  6. roberta

    roberta Established Member My Regimen

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    it seems that it is more potent than minoxidil, isn't it?
     
  7. Dat5Years

    Dat5Years Established Member My Regimen

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    Are you serious?
     
  8. Dat5Years

    Dat5Years Established Member My Regimen

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    https://www.bristolbotanicals.co.uk/pr-1164
    like this?
     
  9. Mandar kumthekar

    Mandar kumthekar Experienced Member My Regimen

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    I can't see new hairs ,all I can see is existing hairs becomes thicker which I don't think a great accomplishment.
     
  10. hailbrotzu

    hailbrotzu Established Member My Regimen

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    Anyone going to try this? I might try it until celino comes out
     
  11. Dat5Years

    Dat5Years Established Member My Regimen

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    Yeah I will if the product I posted is correct its cheap as shit
     
  12. zaman

    zaman Established Member My Regimen

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  13. whatevr

    whatevr Senior Member My Regimen

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    image-01.jpg

    Astilbin and t-Flavanone are quite different from one another. I'm not sure why you're assuming they're interchangeable or that they will have similar effects. The difference between testosterone and estrogen - two functionally very different hormones - is a single methyl and hydroxyl group, and that's a far smaller difference than the one between these two.

    If you want to test the results from this study, you'll have to test t-flavanone. Buying some herb that contains something remotely similar to the chemical used in the study is a far reach.

    I bought the Sensai hair loss lotion which contains t-Flavanone and will start using it soon.
     

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