study dutasteride vs. finasteride (Bryan)

[hair today gone tomorrow]

bryan in another thread you posted this study....if your remember awhile back i asked you if you thought it was possible someone could respond better to dutasteride than to finasteride and you told me no.

In light of this study that you recently posted...has your stance changed at all?....could someone possibly respond better to finasteride?

Peter Mac on hlh still believes some people respond better to finasteride...I am very curious as to what you think....I have been trying to get your attention at the other thread to no avail.

If you dont remember this was the study:
http://jme.endocrinology-journals.org/c ... l/34/3/617

 

[blaze]

finasteride works by inhibiting type 2 5AR.

dutasteride inhibits more type 2 5AR, plus type 1 as well.

How can ppl respond better to finasteride than dutasteride? I dont think it is possible, since both work by inhibiting type 1 5AR.

 

[hair today gone tomorrow]

read the article...supposedly some people have different variations of the 5ar enzyme. I guess it depends on your genotype.

 

[blaze]

So maybe taking both finasteride and dutasteride at the same time isnt redundant after all?

 

[stampede]

Overall, the dual 5{alpha}-reductase inhibitor, dutasteride, has higher affinity for steroid 5{alpha}-reductase type II than finasteride, irrespective of genotype. Dutasteride is also expected to result in lower pharmacogenetic variation than finasteride in vivo, since it displays significantly lower pharmacogenetic variation of the apparent Ki than finasteride in the 30-min assays (see below; Tables 1Go and 2Go). Thus, this compound may also be a better choice in vivo.

That'll do for me...

 

[hair today gone tomorrow]

i wonder why bryan is dodging this question!!

 

[CCS]

I doubt you guys understood that study.

It just said there are two types of 5AR, 1 and 2. Finasteride only inhibits type 2, and dutasteride inhibits both, though not the type 1 too well.

The test was done on the prostate. Says nothing about hair follicles. I'm sure Bryan is not responding because he is tired of repeating himself to people who don't care enough about biochemistry to listen to any of the 1000x he and I have explained this over an over.

Read my web site. I'm done. Oh, and maximal inhibition happens in about 1-2 hours.

 

[hair today gone tomorrow]

NO ccs u misread the study....read it again...there are different variants of the 5arII enzyme...different genotypes....dutasteride takes care of most genotypes but there were 2 variants that finasteride did a better job of inhibiting....in another thread bryan said that dutasteride would be more EFFECTIVE for everyone....but this study says otherwise...its possible that finasteride could have a better effect on A FEW people.

re-read it ccs...

 

[hair today gone tomorrow]

ttt

 

[CCS]

Overall, the dual 5{alpha}-reductase inhibitor, dutasteride, has higher affinity for steroid 5{alpha}-reductase type II than finasteride, irrespective of genotype. Dutasteride is also expected to result in lower pharmacogenetic variation than finasteride in vivo, since it displays significantly lower pharmacogenetic variation of the apparent Ki than finasteride in the 30-min assays (see below; Tables 1Go and 2Go). Thus, this compound may also be a better choice in vivo.

That'll do for me...

that means nothing.

 

[CCS]

well, I'm taking both right now.

 

[hair today gone tomorrow]

well, I'm taking both right now.

that may not be a good idea

 

[little]

well, I'm taking both right now.

that may not be a good idea

why? i am considering doing the same

 

[hair today gone tomorrow]

well, I'm taking both right now.

that may not be a good idea

why? i am considering doing the same

cuz we dont know how the drugs interact with each other....no studies have been done on this

 

[CCS]

I doubt there is any interaction. I take them both with grapefruit. I'm going to drop the dutas though since it is not stronger. I may save it and just use it when I run out of proscar, but I don't trust it 100% like i do the proscar. So maybe I should sell it. 80 dutas for $60.

 

[blaze]

How can dutasteride not be stringer than finasteride?

Even the studies show more hair growth on dutasteride than finasteride. Esp when you take larger doses like 2mg +...

 

[I_Hate_DHT]

Well... anything is possible.

For example I responded better to PROPECIA than GENERIC finasteride...


PD: Let's see who is the first idiot to quote this message and makes a joke.

 

[CCS]

How can dutasteride not be stringer than finasteride?

Even the studies show more hair growth on dutasteride than finasteride. Esp when you take larger doses like 2mg +...

at the 6 month mark, not the 1 year mark. They are all the same at the one year mark, it seems. Maybe some lower doses take longer. I'm sure some low doses don't help at all, like those that don't regrow any hair. but anything that is at least as strong as 1mg of finasteride, or maybe even 0.2mg, seems to catch up to dutasteride in the long run.

 

[mulder]

I doubt there is any interaction. I take them both with grapefruit. I'm going to drop the dutas though since it is not stronger. I may save it and just use it when I run out of proscar, but I don't trust it 100% like i do the proscar. So maybe I should sell it. 80 dutas for $60.

Didn't even know about the grapefruit juice thing. Do you take it on an empty stomach? Maybe it's better to take it at night..or before fasted cardio :lol:

Tips...
To increase absorption of Finasteride and help avoid any loss of that precious 1 - 1.25mg due to digestion; preferably take on an empty stomach ( officially Proscar can be taken with or without food ) with a glass of grapefruit juice. Grapefruit juice contains substances which inhibit certain digestive enzymes that break down Finasteride thus boosting ( more or less doubling ) your bloodsteam uptake of the drug.

 

[jbob]

when you say that 1mg of finasteride catches up to dutasteride, is this with reference to .5mg dt or the full2.5 dose. Do yo mind if I ask which studies show these figures? Cheers