Stemson is going to use minipigs in the next stage of their hair cloning research

werefckd

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“Because the hair germs are neonatal-like,” Hamilton explains, “they are less susceptible to the biochemicals—dihydrotestosterone (DHT), for instance—that damage the dermal papilla in the hair follicle.” As the new hair follicle is formed, its clean, natural environment should offer some protection from those biochemicals.

Whether, or how long, that protection lasts in humans must be determined in clinical trials. To further improve the chances that hair will grow and that the hair follicles will remain healthy, Stemson plans to assess naturally resistant follicles to identify their key protective properties. The company may use those findings to guide hair germ selection.
 

RagnarLothbrok

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If they can clone DHT-resistant donor area follicles it will be good enough. Most people with transplants keep their donor hair for a long time even if they lose all native hair. And even if you lost them, then you can do it again and again anyway.
 

Bf20

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"Geoff Hamilton: That is a good question. It is on our mind, and the idea is to generate long lasting, durable hair follicles, and some of the biology behind DHT resistance is not yet known. And so, as we are performing our experiments and biological discoveries, we’re actually collecting donated hair follicles from patients getting hair transplant procedures and those follicles which are extracted from the back of the head are known to be DHT resistant when they are moved to the recipient location of the head, and they have shown to be long lasting and durable. So, we are using those donated hair follicles for several reasons: 1) it helps us establish a benchmark when establishing our hair cells. We ask, ‘what do they look like compared to normal adult hair follicle cells?’ and 2) it gives us a source of material that helps us look deeper into ‘what is DHT resistance?’ and ‘how does that compare to hairs that are not DHT resistant?’ And the strategy for exactly how we’re going to do that is not crystal clear just yet, it is in the plan; we are frankly just a bit more focused at the moment on consistently, reproducibly building a hair follicle. At the second phase we will focus on DHT resistance and the aesthetic value of the hair – subjects like thickness of hair, color and curl. That is the kind of stuff that I would call the second phase of development. "
Geoff made that statement in September 21'. So we can safely assume that stemson were at that stage 1 1/2 - 2 years.
 

ratty

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So, development will continue several years before a treatment enters human trials, and a few years will pass before that treatment becomes available, assuming it succeeds.

will check back in after 10 years then
 

Super Metroid

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it would be nice if this will take only 10 years:)
Some years for preclinical trials, a couple of years for the actual trials and a couple of years for creating the infrastructure that this treatment would require. Will indeed take a long time even assuming that everything succeeds.
 

froggy7

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Some years for preclinical trials, a couple of years for the actual trials and a couple of years for creating the infrastructure that this treatment would require. Will indeed take a long time even assuming that everything succeeds.
it is not for us only for next generations, 10 years is a very good timeframe:)
 

Roeysdomi

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“Hamilton cautions that Stemson’s approach is currently in preclinical development and still needs to be tested in humans. So, development will continue several years before a treatment enters human trials, and a few years will pass before that treatment becomes available, assuming it succeeds. He adds, “The science we’re performing is so novel, none of us can predict exactly when we’ll be ready for trials.””

-from the link above
 

Raccooner

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Back to the pigs. If we look to the end of the article, Geoff I think gives us a clue. They've must have had some degree of success with some pigs, but the consistency needs work. The key is if they got any human hair to grow in a pig then there is much more proof that hair cloning concept has the ability to work for our skin type as well. Hopefully the new hires will figure out a way to deal with the consistency issue.

Also, Stemson placed a new position for an Assistant Lab Technician. No doubt they're active but wonder how they can afford their payroll hiring so many people? Additionally, the article mentions needing funding for the clinical trial, whenever that comes. Wondering what that would run? Perhaps what they really need is a fundraiser or sales specialist who can recruit a benefactor?
 

RagnarLothbrok

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The problem with Stemson is not only a scientific research one but a manufacturing one. Even if they could find a 100% reliable system to clone a hair follicle, that doesn't mean that they can do it at scale for profit. It's a very complex situation sadly.
 

froggy7

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The problem with Stemson is not only a scientific research one but a manufacturing one. Even if they could find a 100% reliable system to clone a hair follicle, that doesn't mean that they can do it at scale for profit. It's a very complex situation sadly.
100% true, there will ba also a problem with price
 

Super Metroid

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Back to the pigs. If we look to the end of the article, Geoff I think gives us a clue. They've must have had some degree of success with some pigs, but the consistency needs work. The key is if they got any human hair to grow in a pig then there is much more proof that hair cloning concept has the ability to work for our skin type as well. Hopefully the new hires will figure out a way to deal with the consistency issue.

Also, Stemson placed a new position for an Assistant Lab Technician. No doubt they're active but wonder how they can afford their payroll hiring so many people? Additionally, the article mentions needing funding for the clinical trial, whenever that comes. Wondering what that would run? Perhaps what they really need is a fundraiser or sales specialist who can recruit a benefactor?

I think it is kind of a stretch to interpret that sentence as a clue that they are already experiencing some degree of success. They might, but to conclude it is reading too much into it I believe.

Investors are generally smart people, you don't earn your way to collecting the kind of money to invest by falling for cheap marketing tricks. Hiring a sales specialist is imo only a good idea if there are significant results to show: glad to see Stemson is focusing on that.

Absolute best case scenario is that they are close to finishing the preclinicals and find a sponsor that is willing to take the financial burden but demands they trial in Asia for speed reasons. If that works out and they commercialize there, they can slowly build-up the infrastructure and industry while actually treating patients on a small scale and earn money while working towards trialing in the West.

But scenario's usually don't pan out so well, plus it would still be very costly :)
 

werefckd

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Stemson team page is still growing, two fresh additions since last week or so.

I know we are all thirsty for company announcements, however until they refresh their news page again, in the meantime I'm happy to see they are still being able to retain and attract new talent, very strong signal that Stemson is still on track.
 

werefckd

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I wonder what was said during that presentation that happened in last may. The last time Aleksey participated in a talk was in that youtube interview with Dr. Wolf back in 2020 as far as I know. I expect his presentation had more technical "juice" than Geoff's since he is the chief scientist of the company.

Pinging @froggy7 -- maybe you can do another of your great detective works and somehow find the video that presentation like you did with that other one with Geoff?
 

RagnarLothbrok

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Stemson team page is still growing, two fresh additions since last week or so.

I know we are all thirsty for company announcements, however until they refresh their news page again, in the meantime I'm happy to see they are still being able to retain and attract new talent, very strong signal that Stemson is still on track.
1658142655000.png
 

HMI 115 IS THE CURE dude

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View attachment 182651


I wonder what was said during that presentation that happened in last may. The last time Aleksey participated in a talk was in that youtube interview with Dr. Wolf back in 2020 as far as I know. I expect his presentation had more technical "juice" than Geoff's since he is the chief scientist of the company.

Pinging @froggy7 -- maybe you can do another of your great detective works and somehow find the video that presentation like you did with that other one with Geoff?
The one bald guy in the audience: hmm this looks interesting
 

Raccooner

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They (Stemson) keep hiring but what are they doing? That's what they won't tell us. I don't care if they hire 1000 new scientists, researchers or jugglers. I'd rather they hire those with a background in hair, skin and cell anatomy, who understand what's wrong and have the fixes needed. I really don't know why Geoff has confidence that his new hires are going to accomplish anything. It to me looks like he's buying lottery tickets with his hires, hoping one will hit, but the likelihood is next to zero from what I read in these recent biographies. The company at this rate will probably go bust from overextending their budget. That's what worries me. I hope I'm wrong and that these hires will accomplish something needed to advance us to a cure.
 

froggy7

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They (Stemson) keep hiring but what are they doing? That's what they won't tell us. I don't care if they hire 1000 new scientists, researchers or jugglers. I'd rather they hire those with a background in hair, skin and cell anatomy, who understand what's wrong and have the fixes needed. I really don't know why Geoff has confidence that his new hires are going to accomplish anything. It to me looks like he's buying lottery tickets with his hires, hoping one will hit, but the likelihood is next to zero from what I read in these recent biographies. The company at this rate will probably go bust from overextending their budget. That's what worries me. I hope I'm wrong and that these hires will accomplish something needed to advance us to a cure.
I also think that Stemson is headed for collapse, this is just my private opinion, but they do not have a solution, it is certain, if they discovered something long ago they would boast about it, and so they employ shitty scientists and not world-famous experts, Hamilton smiles smartly and tells , but in my opinion it is only a good face for a bad game, Stemson will share the fate of organ technologies is the last company that can give bald hair, creating a hair that will be good quality, will be resistant to dht and will stay for many years is simply an extremely difficult problem to solve , the kids won't solve it after getting a PhD
 
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