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Is anyone aware of where you can read any hair studies done on stemoxydine? I can't find anything.
The closest I can find is this summary of a poster here:
I am looking into getting some powder to play with but I want to make sure it's worth my time first.
For reference, found some solubility data here:
Probably won't be able to get a high concentration without making a "lotion" which is what I understand is what Neogenic is. But should be able to get a few percent either way.
The closest I can find is this summary of a poster here:
Hypoxia is an important characteristic of numerous stem cell reservoirs and recent evidence indicates that this may also hold true for the lower stem cell niche of human hair follicles.
To investigate the potential impact of hypoxia on hair follicle stem and early progenitor cell populations, we measured the colony-forming efficiency (CFE) of keratinocytes derived from the Outer Root Sheath (ORS) of human follicles, cultured under normoxic or hypoxic conditions. Although the absolute number of clones was not statistically different, cell density was reduced under hypoxic culturing conditions, suggesting better control of cell proliferation.
Based on these results, we hypothesized that induction of hypoxia signaling may be important in maintaining hair follicle stem cell functionality. Hypoxia signaling is mediated by HIF1, the a subunit of which is degraded in an oxygen-dependent manner through prolyl-4-hydroxylase (P4H)-mediated hydroxylation. A potent P4H competitive inhibitor, Stemoxydine, was tested for its ability to induce hypoxia-like signaling. Transcriptomic studies show that treatment of hair follicles with Stemoxydine in normoxic conditions modifies the expression of a panel of genes in the same manner as culturing under hypoxic conditions. In addition, when ORS-derived hair follicle cells were grown in normoxic conditions with Stemoxydine, CFE and clone morphology were similar to those observed in hypoxic conditions.
These results suggest that hypoxia may be an important regulator of stem/progenitor cells function in the human hair follicle. We hypothesize that molecules that mimic hypoxic signaling, such as Stemoxydine, may figure as new approach to sustain hair growth and cycling.
I can't find any placebo controlled studies although I know L'Oreal supposedly did one and showed 4% increased density. To investigate the potential impact of hypoxia on hair follicle stem and early progenitor cell populations, we measured the colony-forming efficiency (CFE) of keratinocytes derived from the Outer Root Sheath (ORS) of human follicles, cultured under normoxic or hypoxic conditions. Although the absolute number of clones was not statistically different, cell density was reduced under hypoxic culturing conditions, suggesting better control of cell proliferation.
Based on these results, we hypothesized that induction of hypoxia signaling may be important in maintaining hair follicle stem cell functionality. Hypoxia signaling is mediated by HIF1, the a subunit of which is degraded in an oxygen-dependent manner through prolyl-4-hydroxylase (P4H)-mediated hydroxylation. A potent P4H competitive inhibitor, Stemoxydine, was tested for its ability to induce hypoxia-like signaling. Transcriptomic studies show that treatment of hair follicles with Stemoxydine in normoxic conditions modifies the expression of a panel of genes in the same manner as culturing under hypoxic conditions. In addition, when ORS-derived hair follicle cells were grown in normoxic conditions with Stemoxydine, CFE and clone morphology were similar to those observed in hypoxic conditions.
These results suggest that hypoxia may be an important regulator of stem/progenitor cells function in the human hair follicle. We hypothesize that molecules that mimic hypoxic signaling, such as Stemoxydine, may figure as new approach to sustain hair growth and cycling.
I am looking into getting some powder to play with but I want to make sure it's worth my time first.
For reference, found some solubility data here:
Soluble in 100% ethanol (50mg/ml), DMSO (20mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, 7.2 (1mg/ml)
Probably won't be able to get a high concentration without making a "lotion" which is what I understand is what Neogenic is. But should be able to get a few percent either way.