spironolactone: when does it kick in?

[jonsie150]

im thinking of adding spironolactone to my regime as well. Ive been on rogaine foam for 5 months. Oddly enough my hair looked the best 3 months in, now ive lost some of what i've gained.
How long were you guys using minoxidil before you decided to add spironolactone? am i adding it too soon?

i think you should just add it whenever you want. not much point in waiting

 

[Dblbass128]

I'm a diffuse thinner and I find it hard to apply to the entire scalp.

Switch to liquid I got better results when I did

 

[rcom440]

I'm a diffuse thinner and I find it hard to apply to the entire scalp.

Switch to liquid I got better results when I did

better results? like? Explain please.
Liquid is 2% spironolactone.

 

[guybrush]

I'm a diffuse thinner and I find it hard to apply to the entire scalp.

Switch to liquid I got better results when I did

Yeah, I did too but I started to get sides: hypotension and low libido. It was just a few days after quiting finasteride though...

I switched to a low antiandrogen combination: spironolactone 0,05% and 11 hydroxyprogesterone 0,025%.

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

I believe this one may work even better than the 5%.

 

[Dblbass128]

I'm a diffuse thinner and I find it hard to apply to the entire scalp.

Switch to liquid I got better results when I did

Yeah, I did too but I started to get sides: hypotension and low libido. It was just a few days after quiting finasteride though...

I switched to a low antiandrogen combination: spironolactone 0,05% and 11 hydroxyprogesterone 0,025%.

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

I believe this one may work even better than the 5%.

It was probably the finasteride because topical finasteride gave me wicked sides

 

[Todd]

I'm a diffuse thinner and I find it hard to apply to the entire scalp.

Switch to liquid I got better results when I did

Yeah, I did too but I started to get sides: hypotension and low libido. It was just a few days after quiting finasteride though...

I switched to a low antiandrogen combination: spironolactone 0,05% and 11 hydroxyprogesterone 0,025%.

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

I believe this one may work even better than the 5%.

Really interesting study! And it's from 1988 too, can't believe I haven't noticed it before.

Combining an anti- androgen with an alpha reductase inhibitor certainly seems to be a good approach; remember the synergistic effect of finasteride and ketoconazole.
Add a hair growing agent too, and you've covered pretty much all the bases (maybe throw in an anti- inflammatory agent for good measure)

 

[guybrush]

Yeah, I wish we had the full article because there should be interesting information there. Note that the synergy was only found at low concentrations of spironolactone and progesterone but the regular doses produced neither an additive nor synergistic effect.. it makes me you wonder, doesn't it? Definitely less is more...

They argue it may be due to a greater percutaneous absorption but who knows. I'm also wondering if adding minoxidil could spoil the trick.

 

[guybrush]

hey take a look at this one:

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5

.. topical spironolactone in concentrations as low as 0.06% produced maximal inhibition of cockscomb growth ..

May it be that we are wasting our time, money and health using spironolactone concentrations of up to 5%?

 

[rcom440]

I dont think we are wasting our money Guybrush. I know it thicken my hair and it seem that I lose much less hair since I started spironolactone.

what you mean by "health" ?

 

[rcom440]

Does anyone know how long spironolactone has been on the market as a Hair Loss treatment?
It's relatively new treatment isn't it?

 

[baller234]

Interesting studies guybrush. How can two ingredients be synergistic at low concentrations but lose this synergistic effect at higher concentrations?

Spironolactone is supposedly metabolized before it reaches the bloodstream so even at high concentrations such as 5% there shouldn't be any side effects (at least not with a cream vehicle). However I don't doubt the people that claim side effects from topical spironolactone.

 

[guybrush]

Does anyone know how long spironolactone has been on the market as a Hair Loss treatment?
It's relatively new treatment isn't it?

spironolactone is one of the oldest treatments for hair loss...

BTW, I got sides from spironolactone 5% (low pressure and libido), this is what I meant by health. I understand most people doesn't experience this though...

 

[guybrush]

Interesting studies guybrush. How can two ingredients be synergistic at low concentrations but lose this synergistic effect at higher concentrations?

Who knows... :dunno:

Please someone come and explain lol

 

[rcom440]

does anyone of you use Dr. Lee 5% spironolactone cream? If so how does it smell.

I just got Dr. Lee but it smell to me like a regular cream vs. spironolactone - s5 5% spironolactone Cream has a specific smell.
I use both now. S5 and Dr. Lee's

 

[guybrush]

does anyone of you use Dr. Lee 5% spironolactone cream? If so how does it smell.

I just got Dr. Lee but it smell to me like a regular cream vs. spironolactone - s5 5% spironolactone Cream has a specific smell.

Dr. Lee's have a slight smell of spironolactone if you get close enough. If you feel unsure about it, I suggest you applying a little bit somewhere and then adding a drop of minoxidil.