Spironolactone Is Exhausting ... Switching To Cyproterone

[AnxiousAndy]

Aren't you worried if forehead reduction could possibly make your hairloss worse??

Do you think Oral minoxidil is more effective than topical?

In my own personal, humble opinion i think oral minoxidil is better than topical AND finasteride.

 

[AnxiousAndy]

There was a theory that in some people, when their body detects 5AR suppression it reacts by producing even MORE 5AR, thus making finasteride obsolete and making things even worse. Its called reflex reflex hyperandrogenicity.

Yes i heard that too, although i didnt experience any of the other side effects associated with the mystery condition. Libido is the same, little to no itchiness, no oily skin or spots. Im not sure what to think honestly.. all i know for certain is it really did not work the way it was supposed to and i dont expect it to ever work. The wait 12 months consensus on this drug is bullshit, i think.

 

[g.i joey]

Is it normal?
My hair thins out at the root... (only few hair does this)

I'm so depressed.. literally cried in my bathroom yesterday.. only 18 maaan

You're not alone bro, most of the posters here fall between 18-24

 

[bridgeburn]

In my own personal, humble opinion i think oral minoxidil is better than topical AND finasteride.

lol, I never bothered to try finasteride. i knew it was weak compared to dutasteride and especially to spironolactone and cypro.

 

[AnxiousAndy]

lol, I never bothered to try finasteride. i knew it was weak compared to dutasteride and especially to spironolactone and cypro.

How are your results? How long you been on dutasteride? 0.5mg every day i assume?

 

[bridgeburn]

How are your results? How long you been on dutasteride? 0.5mg every day i assume?

yes and my results are great, but im basically on a extreme trans regimen.

 

[AnxiousAndy]

yes and my results are great, but im basically on a extreme trans regimen.

Can you tell me everything you are on? Im asuming you are not trans?

 

[bridgeburn]

Can you tell me everything you are on? Im asuming you are not trans?

im not trans, started this for my hair. I'll probly make my own thread soon. i've changed the dosages several times but most of the time, 50mg cypro, 1.5 mg Estradiol from oestrogel topically, and .5 mg dutasteride everyday.. and minoxidil 2x a day Every other day.

 

[AnxiousAndy]

im not trans, started this for my hair. I'll probly make my own thread soon. i've changed the dosages several times but most of the time, 50mg cypro, 1.5 mg Estradiol from oestrogel topically, and .5 mg dutasteride everyday.. and minoxidil 2x a day Every other day.

Where do you buy the oestrogel? Ive seen a website for it but it requires a prescription

 

[IdealForehead]

There was a theory that in some people, when their body detects 5AR suppression it reacts by producing even MORE 5AR, thus making finasteride obsolete and making things even worse. Its called reflex reflex hyperandrogenicity.

That makes sense. But then dutasteride should still obliterate the problem, since dutasteride reduces DHT (at least in normal people who are not me) by up to 98% or something (rough from memory).

Here's a graph of DHT suppression for finasteride 5 mg vs and dutasteride 0.5 mg:

The point is, if @AnxiousAndy had trouble with finasteride because it only suppress DHT by 70%, and his body was able to create enough 5-AR to compensate, then that should be far more impossible with dutasteride.

Andy, I would recommend you give dutasteride a try for at least 4 weeks, then get your DHT levels checked. If they're as low as one would expect, you're probably getting a good response and should stick with it. It's approved in Japan and Korea at least as long as you know the risks.

That sucks Andy that hair loss is destroying your life and you had to drop out of school over it. If it is that bad, you should try everything you can to stop it.

As you should know by now, if you don't have a good anti-androgenic regimen you will never win this war in the long run. I hope you can get your life back on track.

Good luck.

 

[bridgeburn]

Where do you buy the oestrogel? Ive seen a website for it but it requires a prescription

Originally i ordered from inhousepharmacy

 

[AnxiousAndy]

@IdealForehead I appriciate your thorough response. I see what you mean.. i may give dutasteride a short course, get a blood test and see whats what in the near future. Yes hair loss has affected my life greatly, im not the baldest 20 year old in the world but it still is significant for my age. At 20 im supposed to have a full head of hair *sigh* How expensive is RU for a 6 months supply? And based on that chart, was the group of people taking dutasteride taking it every day, or ever other day, etc? Im not made of money so if i were to try dutasteride for a few months it would have to be every other day as it is quite expensive.

 

[bridgeburn]

That makes sense. But then dutasteride should still obliterate the problem, since dutasteride reduces DHT (at least in normal people who are not me) by up to 98% or something (rough from memory).

Here's a graph of DHT suppression for finasteride 5 mg vs and dutasteride 0.5 mg:

View attachment 67032

The point is, if @AnxiousAndy had trouble with finasteride because it only suppress DHT by 70%, and his body was able to create enough 5-AR to compensate, then that should be far more impossible with dutasteride.

Andy, I would recommend you give dutasteride a try for at least 4 weeks, then get your DHT levels checked. If they're as low as one would expect, you're probably getting a good response and should stick with it.

If, on the other hand, the problem is that when you suppress your DHT, your body is upregulating androgen receptors, you will need a topical antiandrogen as well to block testosterone from damaging your hair additionally. You could add RU58841 5-7.5% for this as well.

That sucks Andy that hair loss is destroying your life and you had to drop out of school over it. If it is that bad, you should try everything you can to stop it.

I think dutasteride + RU58841 would be a good method with a high likelihood of success in addition to continuing your supplements and oral minoxidil.

As you should know by now, if you don't have a good anti-androgenic regimen you will never win this war in the long run. I hope you consider my suggestion, as it might help you get your life back on track.

Good luck.

So this chart basically says that the meds wear off eventually? this is why i plan to cycle my drugs

 

[IdealForehead]

So this chart basically says that the meds wear off eventually? this is why i plan to cycle my drugs

No. In the study they stopped the treatment and watched the levels get back to normal. The drugs don't wear off. DO NOT cycle your drugs. Get on a good regimen and stick with it.

 

[1knox1]

An 'oral minoxidil' search on google shows that some UK hospitals are prescribing 0.625 mg oral minoxidil per day for some hair loss patients. Don't know what the requirements to get on the scheme are though.

 

[BaldyBalderBald]

No. In the study they stopped the treatment and watched the levels get back to normal. The drugs don't wear off. DO NOT cycle your drugs. Get on a good regimen and stick with it.

ie. For Andy what I am strongly suggesting is dutasteride + RU + oral minoxidil FOR LIFE (or until something better comes out).

That's a strong regimen here mate, break the glass in case of emergency

 

[AnxiousAndy]

No. In the study they stopped the treatment and watched the levels get back to normal. The drugs don't wear off. DO NOT cycle your drugs. Get on a good regimen and stick with it.

ie. For Andy what I am strongly suggesting is dutasteride + RU + oral minoxidil FOR LIFE (or until something better comes out).

I plan on staying on the oral minoxidil long term, im quite pessimistic towards dutasteride given my reaction to finasteride, but i am interesting in giving RU a longterm run.. it seems good for maintainence.