Real question is though... what is taking histogen so long... id love it if someone reached out and found out something regarding a project update in china mexico or even US. sh*t.
Real question is though... what is taking histogen so long... id love it if someone reached out and found out something regarding a project update in china mexico or even US. sh*t.
It doesn't work very well?
Works better than your reading comprehension skills and research abilities, it would seem.
SkinMedica launched a lawsuit against them, delaying their progress by a couple years. Thankfully, SkinMedica LOST the case.
I don't agree w/ KO1 on most things, but this. I have so little faith in Histogen, even if it's released tomorrow. It'll be even more irrelevant by the time it's actually available.
Yes and no. While you're right that the PGE2 and Wnt pathways likely act in concert, they're also linked. bC stabilization is one link in a major cascade involving other pathways including the PGE2, Wnt, VEGF, FGF, and AR cascades. For example. The PGE2/Wnt interaction is also what allows minoxidil to blunt the effect of ARs.
I pointed out bC stabilization as it is consistently marked as a driver for hair growth making it a treatment candidate. Are there other things going on that we don't understand? Of course. Does that mean minoxidil is a mysterious drug? Maybe 10 years ago when we didn't have this information and knew minoxidil only as a vasodilator. What we do not understand are all the signals that promote hair growth, that's what's mysterious.
So then Samumed's new treatment will be very similar to minoxidil. But then again can't SM04554 create new hair follices, while minoxodil can only increase the anagen stage of preexisting hair? Samumed must be keeping secrets as all private companies seem to do.
I just hope that Samumed's hair density base cases included preexisting vellus hairs.
Not sure because "The company expects to report results at a medical conference in spring 2017 ". I think a medical conference will take place between June and September 2017
Why would they wait until Spring 2017 to report results?
I found this link too from Samumed website : https://www.samumed.com/medium/imag...t-american-college-of-rheumatolo_45/view.aspx
I don't understand why they want to present their phase 2 for the next summer. Very strange because this is not the "next medical conference". And why on the paper it's writing " The company expects to report results from an Androgenic Alopecia trial at a medical conference in spring 2017".
It's writing "an AA trial" and not the phase 2 so I think it could be an another trial like a phase 3.
However, I found an another interesting article published this October, 25th.
Source: http://magazine.pomona.edu/2016/fall/how-to-build-a-fountain-of-youth-piece-by-piece/
We can see this
“They’re in diagnostics and they never shared their data, so their whole approach was: ‘Trust us, we got this,’” he says. “Being in the therapeutic field, we’re coming up with drugs; we don’t have that luxury. We cannot say, ‘Trust us, we got it.’ First and foremost, we have the FDA. The FDA is not going to take our word for it.”
The FDA is the gatekeeper, and though less than 10% of proposed new drugs ultimately earn FDA approval, the likelihood increases with each step forward in the lengthy process. The next step for Samumed’s most advanced projects, the hair loss and osteoarthritis drugs, is large Phase III studies with thousands of participants. Some 64% of drugs that begin Phase III studies are submitted for FDA approval and 90% of those are successful, according to a study cited by the independent site fdareview.org ".
So, the next step is the phase 3 for their Hair loss product And maybe, they would present the phase 3 at the medical conference in spring 2017.
What do you think bro ?
I don't know why. If they are waiting until spring 2017 to report their results of the phase 2b. But it's possible that this is an another trial (and not the phase 2b) because they wrote "an androgenetic alopecia trial". I quote my own post if you have not read it. Your answers are in it.
And the next phase for SM is phase 3. Maybe soon.
it looks like they completed the study in April 2016 and the one before that completed November 2015...unless i am reading these reports wrong (which is possible I have no science background at all and i am new to hair loss).
https://clinicaltrials.gov/ct2/results?term=Samumed&cond="Alopecia"
BUT it IS possible perhaps that they are on their 3rd trial/phase? But would it have to be listed?
also found these not sure everyone saw them