- Reaction score
- 84
Paste the link into your browser it works. Not sure why so many people are using Vanicream, doesn't include a proper vehicle to get Sandalore to the hair follicles.
Sandalore - Chemical Used In Perfumes To Mimic Sandalwood Triggers Growth?
- Thread starter Renegade000
- Start date
Wow are you actually joking mate?
That file is on your machine, it's indicated by: "file:///home/chronos..." and you're using a browser to open the file on your hard drive...
As for the Vanicream vehicle, it seems to be doing something for others, so that's why people are trying this.
- Reaction score
- 84
Sorry technologically illiterate, just search "high dose sandalore" and find the research gate editorial. That aside, you need a proper carrier to penetrate the skin which is the job of alcohol. Without that, Sandalore will just likely sit on top of your scalp. I add in propylene glycol as well since alcohol is fast dying and will not give the solution much time to penetrate the scalp.
- Reaction score
- 146
vanicream has propylene glycol
- Reaction score
- 1,321
I use a pipette graduated in tenths of ml. Mix up a liter. Invest in some lab equipment, it's fun and useful to have around. And, your friends will think you're cool sipping brandy from a beaker.
- Reaction score
- 84
The research gate paper includes questions and answers by the authors and other researchers.
- Reaction score
- 84
Okay, but you need a carrier for skin penetration. This is the reason why your bottle of minoxodil has alcohol in it.
It's also has Polyethylene Glycol in it that can penetrate skin, it is also a vehicle that helps deliver other ingredients deeper into skin
- Reaction score
- 84
you underestimate how much of a sponge our skin is, especially the scalp
Why are you guys still claiming 0.01 % to be the right solution??? Only because of that study where they used that directly on the cells for multiple days ??
There is a commercial product out there with sandalore from the company that sponsored this study and in their patent they define a range of sandalore in the solution from 0.1 -10%. So their commercial product should have sandalore in this range. And if they use it why should it be toxic ??
Of course there is no problem sticking with 0.01 but don't be disappointed if you all don't get any effect out of this.
- Reaction score
- 84
Can you post a link to that product? I have yet to see or hear about it until now.
- Reaction score
- 212
So whos gonna go ahead and give 10% a shot? I’m starting to think my 1% isnt cutting it. My shedding is better and my itching is somewhat better but that inflammation is still there.
One more thing anybody else tasting this sh*t all the time? Since i spray/drop it on my head and then rub it in it gets on my hands. Even after a thorough hand wash if i lick my finger hours mater I get this metallic taste. Also when I shower i can almost unavoidably taste it. Anyone else experience this?
One more thing anybody else tasting this sh*t all the time? Since i spray/drop it on my head and then rub it in it gets on my hands. Even after a thorough hand wash if i lick my finger hours mater I get this metallic taste. Also when I shower i can almost unavoidably taste it. Anyone else experience this?
- Reaction score
- 44
The paper/pdf where the opposite effects of higher doses were mentioned.
https://www.researchgate.net/public...851574f7e63e5c/41467-2018-5973-MOESM2-ESM.pdf
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@The balding god posted earlier great results of applying a dilution of 0.75-1.00% in an "unscented lotion". Unfortunately he didn't clarify what this "unscented lotion" is, but if we take his trial in consideration we can assume that this does is effective.
https://www.researchgate.net/public...851574f7e63e5c/41467-2018-5973-MOESM2-ESM.pdf
=============================================================================
@The balding god posted earlier great results of applying a dilution of 0.75-1.00% in an "unscented lotion". Unfortunately he didn't clarify what this "unscented lotion" is, but if we take his trial in consideration we can assume that this does is effective.
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Paper: https://www.researchgate.net/public...851574f7e63e5c/41467-2018-5973-MOESM2-ESM.pdf
In the highlighted bold text below it does state the in the presence of high-dose Sandalore the opposite effects were exerted...but the paper does not state what concentration "high-dose Sandalore" is....
"There is some concern that the effects of Sandalore® require exposure to relatively high concentrations for 6 days. Under those circumstances can the authors confidently rule out non- specific effects, possibly even membrane permeability to this volatile compound that may be at work?
Thanks for raising this important point. In our previous study (Busse et al., 2014), we had carefully addressed the specificity and receptor dependence of Sandalore® effects at the relatively high concentration tested in human HaCaT cells and primary human epidermal keratinocytes. For example, we had demonstrated that after 5 days of Sandalore® stimulation in the presence of specific antagonist of OR2AT4 or of relevant signalling pathway blockers of adenylyl cyclase (MDL-12.330A or SQ-22536) and CNG channel (L-cis Diltiazem), the Sandalore® effect in HaCaT cells or primary human epidermal keratinocytes was completely blocked, without any effects on cell morphology or any other cell biology parameter evaluated. In addition, the co-application of the specific OR2AT4 antagonist Phenirat® with Sandalore® (1:1, 500 mM) completely blocked Sandalore® -induced calcium signals in HaCaT cells indicating that the effects of Sandalore® are based on the activation of OR2AT4 inkeratinocytes.
While these cell culture data demonstrated OR2AT4-dependency of the Sandalore® effects on human keratinocytes in vitro (for details, see Busse et al., 2014), we agree that even the Phenirat® + Sandalore® co-stimulation experiment (which showed that Sandalore® effects on the HF can be partially antagonized by Phenirat® only in the presence of Sandalore® ) does not “confidently rule out” that OR2AT4-INDEPENDENT effects, possibly including even changes in membrane permeability to this volatile compound, might also have been at work, given the relatively high concentration of Sandalore® and long duration ofHF organ culture.
That is exactly why we went one key step further and silenced OR2AT4 in organ-cultured HFs (incidentally, to the best of our knowledge, this is the first time that any olfactory receptor has been successfully knocked-down in any human [mini-] organ). This clearly showed that – notably in the presence of high-dose Sandalore® ! – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both, hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and up-regulated hair matrix keratinocyte apoptosis) and intrafollicular IGF-1 production.
However, to alert readers to the important caveat raised by the expert reviewer, we have complemented the revised Discussion with the following supplementary text(supplementary text 5):
“Previously, we had addressed the specificity and receptor dependence of Sandalore® effects at the relatively high concentration tested here in human HaCaT cells and primary human epidermal keratinocytes (Busse et al 2014). This had demonstrated that after 5 days of Sandalore® stimulation in the presence of specific antagonist of OR2AT4 or of relevant signalling pathway blockers (adenylyl cyclase inhibition by MDL-12.330A or SQ-22536; CNG channel inhibition by L-cis Diltiazem), the Sandalore® effect in HaCaT cells or primary human epidermal keratinocytes was completely blocked, without any effects on cell morphology or any other cell biology parameter evaluated. In addition, co-application of the specific OR2AT4 antagonist Phenirat® with Sandalore® (1:1, 500 mM) completely blocked Sandalore® -induced calcium signals in HaCaT cells (Busse et al. 2014), indicating that the effects of Sandalore® are based on the activation of OR2AT4 in keratinocytes. Most importantly, silencing OR2AT4 in organ-cultured HFs clearly showed that – notably in the presence of high-dose Sandalore® – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both, hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and upregulated hair matrix keratinocyte apoptosis) and intrafollicularIGF-1 production. “"
In the highlighted bold text below it does state the in the presence of high-dose Sandalore the opposite effects were exerted...but the paper does not state what concentration "high-dose Sandalore" is....
"There is some concern that the effects of Sandalore® require exposure to relatively high concentrations for 6 days. Under those circumstances can the authors confidently rule out non- specific effects, possibly even membrane permeability to this volatile compound that may be at work?
Thanks for raising this important point. In our previous study (Busse et al., 2014), we had carefully addressed the specificity and receptor dependence of Sandalore® effects at the relatively high concentration tested in human HaCaT cells and primary human epidermal keratinocytes. For example, we had demonstrated that after 5 days of Sandalore® stimulation in the presence of specific antagonist of OR2AT4 or of relevant signalling pathway blockers of adenylyl cyclase (MDL-12.330A or SQ-22536) and CNG channel (L-cis Diltiazem), the Sandalore® effect in HaCaT cells or primary human epidermal keratinocytes was completely blocked, without any effects on cell morphology or any other cell biology parameter evaluated. In addition, the co-application of the specific OR2AT4 antagonist Phenirat® with Sandalore® (1:1, 500 mM) completely blocked Sandalore® -induced calcium signals in HaCaT cells indicating that the effects of Sandalore® are based on the activation of OR2AT4 inkeratinocytes.
While these cell culture data demonstrated OR2AT4-dependency of the Sandalore® effects on human keratinocytes in vitro (for details, see Busse et al., 2014), we agree that even the Phenirat® + Sandalore® co-stimulation experiment (which showed that Sandalore® effects on the HF can be partially antagonized by Phenirat® only in the presence of Sandalore® ) does not “confidently rule out” that OR2AT4-INDEPENDENT effects, possibly including even changes in membrane permeability to this volatile compound, might also have been at work, given the relatively high concentration of Sandalore® and long duration ofHF organ culture.
That is exactly why we went one key step further and silenced OR2AT4 in organ-cultured HFs (incidentally, to the best of our knowledge, this is the first time that any olfactory receptor has been successfully knocked-down in any human [mini-] organ). This clearly showed that – notably in the presence of high-dose Sandalore® ! – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both, hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and up-regulated hair matrix keratinocyte apoptosis) and intrafollicular IGF-1 production.
However, to alert readers to the important caveat raised by the expert reviewer, we have complemented the revised Discussion with the following supplementary text(supplementary text 5):
“Previously, we had addressed the specificity and receptor dependence of Sandalore® effects at the relatively high concentration tested here in human HaCaT cells and primary human epidermal keratinocytes (Busse et al 2014). This had demonstrated that after 5 days of Sandalore® stimulation in the presence of specific antagonist of OR2AT4 or of relevant signalling pathway blockers (adenylyl cyclase inhibition by MDL-12.330A or SQ-22536; CNG channel inhibition by L-cis Diltiazem), the Sandalore® effect in HaCaT cells or primary human epidermal keratinocytes was completely blocked, without any effects on cell morphology or any other cell biology parameter evaluated. In addition, co-application of the specific OR2AT4 antagonist Phenirat® with Sandalore® (1:1, 500 mM) completely blocked Sandalore® -induced calcium signals in HaCaT cells (Busse et al. 2014), indicating that the effects of Sandalore® are based on the activation of OR2AT4 in keratinocytes. Most importantly, silencing OR2AT4 in organ-cultured HFs clearly showed that – notably in the presence of high-dose Sandalore® – OR2AT4 knock-down exerted the opposite effects of agonist treatment alone and profoundly inhibited both, hair growth (i.e. OR2AT4 siRNA shortened anagen and prematurely induced catagen and upregulated hair matrix keratinocyte apoptosis) and intrafollicularIGF-1 production. “"