Samumed sm04554. Only drug on phase 3

M

Miao

New Member
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guys I was thinking of a hypothesis, anyone who practices bodybuilding here, especially with substance use, will have heard of sarms. or Selective Androgen Receptor Modulators and Serm Selective estrogen receptor modulators, as well as those suffering from Androgenetic Alopecia, under certain sarms lose more hair because the receptors become more "related" to androgens, and therefore fall, if estrogens increase growth, and rather than modifying a gene, finding a serm that attaches itself to the follicles, bringing them more "similar" to the estrogen we already have in the body, with possible improvements?
 
Selb

Selb

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Reaction score
637
Code: 
['[AA: Gene-GSTP1 D | Estro: Gene-GSTP1 U]', '[AA: Gene-CD44 U | Estro: Gene-CD44 D]', '[AA: Gene-ITGAV U | Estro: Gene-ITGAV D]', '[AA: Gene-TP53 U | Estro: Gene-TP53 D]', '[AA: Gene-CCT8 U | Estro: Gene-CCT8 D]', '[AA: Gene-FOSB U | Estro: Gene-FOS D]', '[AA: Gene-CLASP2 U | Estro: Gene-CASP2 D]', '[AA: Gene-MAPK13 U | Estro: Gene-MAPK1 D]', '[AA: Gene-EIF4H U | Estro: Gene-EIF4H D]', '[AA: Gene-COL1A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-HOPX U | Estro: Gene-HOPX D]', '[AA: Gene-COMP D | Estro: Gene-COMP U]', '[AA: Gene-AIFM1 U | Estro: Gene-AIM1 D]', '[AA: Gene-CDHR1 U | Estro: Gene-CDH1 D]', '[AA: Gene-EGF D | Estro: Gene-EGFR U]', '[AA: Gene-KRT15 U | Estro: Gene-KRT1 D]', '[AA: Gene-SOCS5 U | Estro: Gene-SOCS5 D]', '[AA: Gene-COL21A1 D | Estro: Gene-COL16A1 U]', '[AA: Gene-COL21A1 D | Estro: Gene-COL18A1 U]', '[AA: Gene-COL21A1 D | Estro: Gene-COL11A1 U]', '[AA: Gene-COL6A3 U | Estro: Gene-COL6A3 D]', '[AA: Gene-CLUH U | Estro: Gene-CLU D]', '[AA: Gene-GLRX U | Estro: Gene-GLRX D]', '[AA: Gene-COL11A2 D | Estro: Gene-COL11A1 U]', '[AA: Gene-IL6R U | Estro: Gene-IL6 D]', '[AA: Gene-XRCC5 U | Estro: Gene-XRCC5 D]', '[AA: Gene-SPARCL1 U | Estro: Gene-SPARCL1 D]', '[AA: Gene-CX3CL1 U | Estro: Gene-CXCL1 D]', '[AA:
Gene-S100A7 U | Estro: Gene-S100A7 D]', '[AA: Gene-IL1A U | Estro: Gene-IL1A D]', '[AA: Gene-LAMA4 U | Estro: Gene-LAMA4 D]', '[AA: Gene-COL14A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-HADH U | Estro: Gene-HADHB D]', '[AA: Gene-UNG U | Estro: Gene-UNG D]', '[AA: Gene-CDH5 U | Estro: Gene-CDH5 D]', '[AA: Gene-COL10A1 D | Estro: Gene-COL16A1 U]', '[AA: Gene-COL10A1 D | Estro: Gene-COL18A1 U]', '[AA: Gene-COL10A1 D | Estro: Gene-COL11A1 U]', '[AA: Gene-LUM U | Estro: Gene-LUM D]', '[AA: Gene-KRT14 D | Estro: Gene-KRT14 U]', '[AA: Gene-COL17A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-COL16A1 D | Estro: Gene-COL16A1 U]', '[AA: Gene-COL16A1 D | Estro: Gene-COL18A1 U]', '[AA: Gene-COL16A1 D | Estro: Gene-COL11A1 U]', '[AA: Gene-CCND1 D | Estro: Gene-CCND1 U]', '[AA: Gene-CCNG2 U | Estro: Gene-CCNG2 D]', '[AA: Gene-CASP7 U | Estro: Gene-CASP7 D]', '[AA: Gene-FLG U | Estro: Gene-FLG D]', '[AA: Gene-KRT24 D | Estro: Gene-KRT2 U]', '[AA: Gene-PFN1 U | Estro: Gene-FN1 D]', '[AA: Gene-KRT1 U | Estro: Gene-KRT1 D]', '[AA: Gene-MAP2K6 U | Estro: Gene-MAPK6 D]', '[AA: Gene-TNFSF10 U |
Estro: Gene-TNFSF10 D]', '[AA: Gene-TNFRSF1A U | Estro: Gene-TNFRSF1A D]', '[AA: Gene-TNFRSF1A U | Estro: Gene-TNFRSF19 D]', '[AA: Gene-NOV U | Estro: Gene-NOV D]', '[AA: Gene-GLIPR1 U | Estro: Gene-GLIPR1 D]', '[AA: Gene-CALU U | Estro: Gene-CLU D]', '[AA: Gene-CXCL12 U | Estro: Gene-CXCL1 D]', '[AA: Gene-PSAP U | Estro: Gene-PSAP D]', '[AA: Gene-HSPD1 U | Estro: Gene-HSPD1 D]', '[AA: Gene-CTNNBIP1 U | Estro: Gene-CTNNB1 D]', '[AA: Gene-SGPP1 U | Estro: Gene-SPP1 D]', '[AA: Gene-CXCL13 U | Estro: Gene-CXCL1 D]', '[AA: Gene-GLRX5 U | Estro: Gene-GLRX D]', '[AA: Gene-NKTR D | Estro: Gene-NKTR U]', '[AA: Gene-COL13A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-SERPINB1 U | Estro: Gene-SERPINE1 D]', '[AA: Gene-KRT85 D | Estro: Gene-KRT5 U]', '[AA: Gene-B2M U | Estro: Gene-B2M D]', '[AA: Gene-ACO1 U | Estro: Gene-ACOX1 D]', '[AA: Gene-RAF1 U | Estro: Gene-RAF1 D]', '[AA: Gene-CXCL10 U | Estro: Gene-CXCL1 D]', '[AA: Gene-KRT10 U | Estro: Gene-KRT1 D]', '[AA: Gene-ADAM19 U | Estro: Gene-ADAM9 D]', '[AA: Gene-RRM2 D | Estro: Gene-SRRM2 U]', '[AA: Gene-MMP14 U | Estro: Gene-MMP1 D]', '[AA: Gene-FMOD U | Estro: Gene-FMOD D]', '[AA: Gene-TNFSF13 U | Estro: Gene-TNFSF10 D]', '[AA: Gene-JAK1 U | Estro: Gene-JAK1 D]', '[AA: Gene-CANX U | Estro: Gene-CANX D]', '[AA: Gene-CD36 U | Estro: Gene-CD36 D]', '[AA: Gene-MAP3K6 U | Estro: Gene-MAPK6 D]', '[AA: Gene-AIMP1 U | Estro: Gene-AIM1 D]', '[AA: Gene-LGALS8 U | Estro: Gene-LGALS8 D]', '[AA: Gene-PPP1R13L D | Estro: Gene-PPP1R13L U]', '[AA: Gene-FOS U | Estro: Gene-FOS D]', '[AA: Gene-CD4 U | Estro: Gene-CD34 D]', '[AA: Gene-CD4 U | Estro: Gene-CD44 D]', '[AA: Gene-DCN U | Estro: Gene-DCN D]', '[AA: Gene-KRIT1 U | Estro: Gene-KRT1 D]', '[AA: Gene-MAP2K2 D | Estro: Gene-MAP2K2 U]', '[AA: Gene-AOX1 U | Estro: Gene-ACOX1 D]', '[AA: Gene-FBN1 U | Estro: Gene-FN1 D]', '[AA: Gene-CXCL14 U | Estro: Gene-CXCL1 D]', '[AA: Gene-TNFRSF21 U | Estro: Gene-TNFRSF1A D]', '[AA: Gene-TNFRSF21 U | Estro: Gene-TNFRSF19 D]', '[AA: Gene-MAP3K14 U | Estro: Gene-MAPK14 D]', '[AA: Gene-AK1 U | Estro: Gene-JAK1 D]', '[AA: Gene-KRT75 D | Estro: Gene-KRT75 U]', '[AA: Gene-KRT75 D | Estro: Gene-KRT5 U]', '[AA: Gene-MFN1 U | Estro: Gene-FN1 D]', '[AA: Gene-COL18A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-TNFRSF10B U | Estro: Gene-TNFSF10 D]', '[AA: Gene-TNFRSF1B U | Estro: Gene-TNFRSF1A D]', '[AA: Gene-TNFRSF1B U | Estro: Gene-TNFRSF19 D]', '[AA: Gene-SDCBP U | Estro: Gene-SDCBP D]', '[AA: Gene-KRT32 D | Estro: Gene-KRT2 U]', '[AA: Gene-ITGA6 U | Estro: Gene-ITGA6 D]', '[AA: Gene-IGFBP3 U | Estro: Gene-IGFBP3 D]', '[AA: Gene-CXCL1 U | Estro: Gene-CXCL1 D]', '[AA: Gene-SEC31A U | Estro: Gene-SEC31A D]', '[AA: Gene-FN1 U | Estro: Gene-FN1 D]', '[AA: Gene-SERPING1 U | Estro: Gene-SERPINE1 D]', '[AA: Gene-PHB U | Estro: Gene-P4HB D]', '[AA: Gene-MAPK14 U | Estro: Gene-MAPK14 D]', '[AA: Gene-MAPK14 U | Estro: Gene-MAPK1 D]', '[AA: Gene-COL11A1 D | Estro: Gene-COL16A1 U]', '[AA: Gene-COL11A1 D | Estro: Gene-COL18A1 U]', '[AA: Gene-COL11A1 D | Estro: Gene-COL11A1 U]', '[AA: Gene-PLIN2 U | Estro: Gene-PLIN2 D]', '[AA: Gene-TAGLN3 D | Estro: Gene-TAGLN
U]', '[AA: Gene-KRT19 U | Estro: Gene-KRT1 D]', '[AA: Gene-HADHB U | Estro: Gene-HADHB D]', '[AA: Gene-KRT5 D | Estro: Gene-KRT75 U]', '[AA: Gene-KRT5 D |
Estro: Gene-KRT5 U]', '[AA: Gene-CXCL11 U | Estro: Gene-CXCL1 D]', '[AA: Gene-PDLIM7 D | Estro: Gene-PDLIM7 U]', '[AA: Gene-NDUFAF3 D | Estro: Gene-NDUFA3
U]', '[AA: Gene-VCAN U | Estro: Gene-VCAN D]', '[AA: Gene-MMP12 U | Estro: Gene-MMP1 D]', '[AA: Gene-SERPINH1 U | Estro: Gene-SERPINE1 D]', '[AA: Gene-SRRM2 D | Estro: Gene-SRRM2 U]', '[AA: Gene-PTGDS U | Estro: Gene-PTGDS D]', '[AA: Gene-FOSL2 D | Estro: Gene-FOSL2 U]', '[AA: Gene-ITGB1 U | Estro: Gene-ITGB1 D]', '[AA: Gene-CDH19 U | Estro: Gene-CDH1 D]', '[AA: Gene-CASP8 U | Estro: Gene-CASP8 D]', '[AA: Gene-ASAH1 U | Estro: Gene-ASAH1 D]', '[AA: Gene-FLNA D
| Estro: Gene-FLNA U]', '[AA: Gene-CTNNBL1 U | Estro: Gene-CTNNB1 D]', '[AA: Gene-COL15A1 U | Estro: Gene-COL12A1 D]', '[AA: Gene-SERPINE2 U | Estro: Gene-SERPINE1 D]', '[AA: Gene-KRT35 D | Estro: Gene-KRT5 U]', '[AA: Gene-P4HB U | Estro: Gene-P4HB D]', '[AA: Gene-EPS15 U | Estro: Gene-EPS15 D]', '[AA: Gene-EGFR D | Estro: Gene-EGFR U]', '[AA: Gene-VLDLR U | Estro: Gene-LDLR D]', '[AA: Gene-CD34 U | Estro: Gene-CD34 D]', '[AA: Gene-EDNRB U | Estro: Gene-EDNRB D]', '[AA: Gene-MMP11 U | Estro: Gene-MMP1 D]', '[AA: Gene-TAGLN2 D | Estro: Gene-TAGLN U]', '[AA: Gene-LAMA5 D | Estro: Gene-LAMA5 U]', '[AA: Gene-CDH11 U
| Estro: Gene-CDH1 D]', '[AA: Gene-LTBP1 U | Estro: Gene-LTBP1 D]', '[AA: Gene-PTK7 D | Estro: Gene-PTK7 U]', '[AA: Gene-ACTB D | Estro: Gene-ACTB U]', '[AA: Gene-STAT2 U | Estro: Gene-STAT2 D]', '[AA: Gene-S100A9 U | Estro: Gene-S100A9 D]', '[AA: Gene-STAT1 U | Estro: Gene-STAT1 D]', '[AA: Gene-TFDP1 U | Estro: Gene-TFDP1 D]', '[AA: Gene-PTK2 U | Estro: Gene-PTK2 D]', '[AA: Gene-ITGBL1 U | Estro: Gene-ITGB1 D]', '[AA: Gene-IL16 U | Estro: Gene-IL6 D]', '[AA: Gene-EIF3E U | Estro: Gene-EIF3E D]', '[AA: Gene-PDZK1IP1 U | Estro: Gene-PDZK1IP1 D]', '[AA: Gene-SPP1 U | Estro: Gene-SPP1 D]', '[AA: Gene-KRT3 D | Estro: Gene-KRT37 U]', '[AA: Gene-FGFR2 U | Estro: Gene-FGFR2 D]', '[AA: Gene-SAT1 U | Estro: Gene-STAT1 D]', '[AA: Gene-CSPG4 D | Estro: Gene-CSPG4 U]', '[AA: Gene-ATP5D D | Estro: Gene-ATP5D U]', '[AA: Gene-MAPK1 U | Estro: Gene-MAPK14 D]', '[AA: Gene-MAPK1 U | Estro: Gene-MAPK1 D]', '[AA: Gene-CCNC U | Estro: Gene-CCNC D]', '[AA: Gene-SERPINF1 U | Estro: Gene-SERPINE1 D]', '[AA: Gene-TXLNA U | Estro: Gene-TXLNA D]', '[AA: Gene-TNFRSF14 U | Estro: Gene-TNFRSF1A D]', '[AA: Gene-TNFRSF14 U | Estro: Gene-TNFRSF19 D]', '[AA: Gene-BASP1 D | Estro: Gene-BASP1 U]', '[AA: Gene-BCL2L13 U | Estro: Gene-BCL2L1 D]', '[AA: Gene-BCL2L13 U | Estro: Gene-BCL2L13 D]', '[AA: Gene-DSC1 U | Estro: Gene-DSC1 D]', '[AA: Gene-CD55 U | Estro: Gene-CD55 D]', '[AA: Gene-CLU U | Estro: Gene-CLU
D]', '[AA: Gene-MAP2K1 U | Estro: Gene-MAPK1 D]', '[AA: Gene-ABCC5 U | Estro: Gene-ABCC5 D]', '[AA: Gene-PSEN1 U | Estro: Gene-PSEN1 D]']
Click to expand...
Alright here's a much bigger list. I've gone ahead and upped the match/criteria requirements to require more of a character match with the gene names, it's 85% now. I haven't taken the time to deep dive what this implies. But I think my next step is to check which pathways are relevant and what genes may be something to look more into. Plus the mean fold change may be important, so I’ll parse my list in both datasets for the most extreme fold changes by magnitude
 
Last edited:
InBeforeTheCure

InBeforeTheCure

Established Member
My Regimen
Reaction score
950
Selb said:
Alright here's a much bigger list. I've gone ahead and upped the match/criteria requirements to require more of a character match with the gene names, it's 85% now. I haven't taken the time to deep dive what this implies. But I think my next step is to check which pathways are relevant and what genes may be something to look more into. Plus the mean fold change may be important, so I’ll parse my list in both datasets for the most extreme fold changes by magnitude
Click to expand...
You should include only 100% matches.

You can run gene ontology enrichment analysis on this site and download the results. I found, using an absolute log2 fold change of at least 0.5, 362 biological processes enriched in the opposite direction in the E2 vs. A.G.A. datasets compared to only 174 in the same direction.

Of the processes enriched in the opposite direction, these are enriched in both the upregulated E2 dataset and downregulated in the A.G.A. dataset:

Code: 
tendon development (GO:0035989)
hair cycle (GO:0042633)
molting cycle (GO:0042303)
cornification (GO:0070268)
collagen fibril organization (GO:0030199)
hair follicle development (GO:0001942)
skin epidermis development (GO:0098773)
hair cycle process (GO:0022405)
molting cycle process (GO:0022404)
skin development (GO:0043588)
keratinization (GO:0031424)
keratinocyte differentiation (GO:0030216)
epidermal cell differentiation (GO:0009913)
ossification (GO:0001503)
epidermis development (GO:0008544)
extracellular matrix organization (GO:0030198)
extracellular structure organization (GO:0043062)
epithelial cell differentiation (GO:0030855)
epithelium development (GO:0060429)
muscle structure development (GO:0061061)
supramolecular fiber organization (GO:0097435)
morphogenesis of an epithelium (GO:0002009)
tissue morphogenesis (GO:0048729)
cell population proliferation (GO:0008283)
tissue development (GO:0009888)
cell death (GO:0008219)
cell adhesion (GO:0007155)
tube morphogenesis (GO:0035239)
programmed cell death (GO:0012501)
biological adhesion (GO:0022610)
circulatory system development (GO:0072359)
cell development (GO:0048468)
animal organ development (GO:0048513)
anatomical structure morphogenesis (GO:0009653)
cell differentiation (GO:0030154)
cellular developmental process (GO:0048869)
system development (GO:0048731)
multicellular organism development (GO:0007275)
regulation of developmental process (GO:0050793)
anatomical structure development (GO:0048856)
developmental process (GO:0032502)
multicellular organismal process (GO:0032501)

These were enriched in the downregulated E2 dataset and upregulated A.G.A. dataset:

Code: 
regulation of transforming growth factor beta production (GO:0071634)
positive regulation of stem cell proliferation (GO:2000648)
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)
response to cadmium ion (GO:0046686)
positive regulation of wound healing (GO:0090303)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
interferon-gamma-mediated signaling pathway (GO:0060333)
positive regulation of tumor necrosis factor production (GO:0032760)
regulation of smooth muscle cell proliferation (GO:0048660)
regulation of leukocyte chemotaxis (GO:0002688)
positive regulation of cysteine-type endopeptidase activity (GO:2001056)
regulation of coagulation (GO:0050818)
positive regulation of interleukin-12 production (GO:0032735)
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)
response to lipopolysaccharide (GO:0032496)
positive regulation of peptidase activity (GO:0010952)
regulation of blood coagulation (GO:0030193)
positive regulation of interleukin-8 production (GO:0032757)
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)
regulation of hemostasis (GO:1900046)
response to molecule of bacterial origin (GO:0002237)
regulation of interleukin-12 production (GO:0032655)
positive regulation of endopeptidase activity (GO:0010950)
regulation of cysteine-type endopeptidase activity (GO:2000116)
extracellular matrix organization (GO:0030198)
extracellular structure organization (GO:0043062)
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)
positive regulation of leukocyte migration (GO:0002687)
cellular response to lipopolysaccharide (GO:0071222)
maternal process involved in female pregnancy (GO:0060135)
positive regulation of chemotaxis (GO:0050921)
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)
regulation of wound healing (GO:0061041)
regulation of fibroblast proliferation (GO:0048145)
cellular response to molecule of bacterial origin (GO:0071219)
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)
negative regulation of epithelial cell proliferation (GO:0050680)
regulation of angiogenesis (GO:0045765)
positive regulation of proteolysis (GO:0045862)
regulation of vasculature development (GO:1901342)
peptide cross-linking (GO:0018149)
cellular response to biotic stimulus (GO:0071216)
positive regulation of smooth muscle cell proliferation (GO:0048661)
response to reactive oxygen species (GO:0000302)
negative regulation of blood vessel morphogenesis (GO:2000181)
negative regulation of vasculature development (GO:1901343)
regulation of response to wounding (GO:1903034)
response to mechanical stimulus (GO:0009612)
regulation of cell-substrate adhesion (GO:0010810)
negative regulation of response to wounding (GO:1903035)
positive regulation of interleukin-6 production (GO:0032755)
regulation of tumor necrosis factor production (GO:0032680)
regulation of cytokine production involved in immune response (GO:0002718)
platelet degranulation (GO:0002576)
myeloid leukocyte migration (GO:0097529)
negative regulation of wound healing (GO:0061045)
regulation of interleukin-8 production (GO:0032677)
antimicrobial humoral response (GO:0019730)
cellular response to acid chemical (GO:0071229)
myeloid leukocyte mediated immunity (GO:0002444)
leukocyte degranulation (GO:0043299)
neutrophil mediated immunity (GO:0002446)
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)
myeloid cell activation involved in immune response (GO:0002275)
leukocyte chemotaxis (GO:0030595)
neutrophil degranulation (GO:0043312)
neutrophil activation involved in immune response (GO:0002283)
cellular response to transforming growth factor beta stimulus (GO:0071560)
positive regulation of leukocyte proliferation (GO:0070665)
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)
leukocyte activation involved in immune response (GO:0002366)
neutrophil activation (GO:0042119)
regulation of leukocyte migration (GO:0002685)
cell activation involved in immune response (GO:0002263)
myeloid leukocyte activation (GO:0002274)
granulocyte activation (GO:0036230)
positive regulation of cell death (GO:0010942)
blood vessel development (GO:0001568)
vasculature development (GO:0001944)
cytokine-mediated signaling pathway (GO:0019221)
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)
antigen processing and presentation of exogenous peptide antigen (GO:0002478)
response to transforming growth factor beta (GO:0071559)
regulation of chemotaxis (GO:0050920)
skin development (GO:0043588)
positive regulation of cytokine production (GO:0001819)
positive regulation of cell adhesion (GO:0045785)
regulation of peptidase activity (GO:0052547)
negative regulation of apoptotic process (GO:0043066)
regulated exocytosis (GO:0045055)
antigen processing and presentation of exogenous antigen (GO:0019884)
response to metal ion (GO:0010038)
cellular response to external stimulus (GO:0071496)
negative regulation of cell death (GO:0060548)
negative regulation of programmed cell death (GO:0043069)
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)
response to fibroblast growth factor (GO:0071774)
regulation of interleukin-6 production (GO:0032675)
regulation of endopeptidase activity (GO:0052548)
response to glucocorticoid (GO:0051384)
antigen processing and presentation of peptide antigen (GO:0048002)
T cell activation (GO:0042110)
protein processing (GO:0016485)
antigen processing and presentation (GO:0019882)
regulation of proteolysis (GO:0030162)
regulation of cell development (GO:0060284)
circulatory system development (GO:0072359)
regulation of epithelial cell proliferation (GO:0050678)
cellular response to lipid (GO:0071396)
response to tumor necrosis factor (GO:0034612)
exocytosis (GO:0006887)
leukocyte mediated immunity (GO:0002443)
leukocyte migration (GO:0050900)
response to lipid (GO:0033993)
cell chemotaxis (GO:0060326)
response to inorganic substance (GO:0010035)
wound healing (GO:0042060)
leukocyte activation (GO:0045321)
regulation of myeloid cell differentiation (GO:0045637)
positive regulation of cell migration (GO:0030335)
response to cytokine (GO:0034097)
secretion by cell (GO:0032940)
response to interferon-gamma (GO:0034341)
cellular response to cytokine stimulus (GO:0071345)
negative regulation of cellular component movement (GO:0051271)
response to corticosteroid (GO:0031960)
export from cell (GO:0140352)
negative regulation of cell migration (GO:0030336)
cellular response to interferon-gamma (GO:0071346)
response to oxygen levels (GO:0070482)
positive regulation of cell motility (GO:2000147)
cellular response to tumor necrosis factor (GO:0071356)
cell activation (GO:0001775)
regulation of cell adhesion (GO:0030155)
regulation of cell death (GO:0010941)
multicellular organismal homeostasis (GO:0048871)
positive regulation of cellular component movement (GO:0051272)
secretion (GO:0046903)
positive regulation of cell-cell adhesion (GO:0022409)
positive regulation of locomotion (GO:0040017)
positive regulation of response to external stimulus (GO:0032103)
regulation of cytokine production (GO:0001817)
negative regulation of cell motility (GO:2000146)
negative regulation of developmental process (GO:0051093)
inflammatory response (GO:0006954)
cell population proliferation (GO:0008283)
regulation of programmed cell death (GO:0043067)
regulation of cell migration (GO:0030334)
regulation of body fluid levels (GO:0050878)
response to ketone (GO:1901654)
immune system development (GO:0002520)
regulation of apoptotic process (GO:0042981)
response to bacterium (GO:0009617)
positive regulation of leukocyte cell-cell adhesion (GO:1903039)
positive regulation of defense response (GO:0031349)
regulation of cell motility (GO:2000145)
response to wounding (GO:0009611)
response to peptide (GO:1901652)
response to virus (GO:0009615)
hematopoietic or lymphoid organ development (GO:0048534)
negative regulation of cell population proliferation (GO:0008285)
positive regulation of developmental process (GO:0051094)
immune effector process (GO:0002252)
regulation of leukocyte proliferation (GO:0070663)
positive regulation of intracellular signal transduction (GO:1902533)
positive regulation of T cell activation (GO:0050870)
hemopoiesis (GO:0030097)
response to growth factor (GO:0070848)
regulation of locomotion (GO:0040012)
cellular response to growth factor stimulus (GO:0071363)
positive regulation of immune effector process (GO:0002699)
regulation of cellular component movement (GO:0051270)
negative regulation of endopeptidase activity (GO:0010951)
regulation of anatomical structure morphogenesis (GO:0022603)
response to steroid hormone (GO:0048545)
regulation of multicellular organismal development (GO:2000026)
negative regulation of proteolysis (GO:0045861)
negative regulation of locomotion (GO:0040013)
positive regulation of phosphorylation (GO:0042327)
negative regulation of cell differentiation (GO:0045596)
positive regulation of cell differentiation (GO:0045597)
regulation of inflammatory response (GO:0050727)
cell migration (GO:0016477)
positive regulation of cell population proliferation (GO:0008284)
response to oxygen-containing compound (GO:1901700)
cell adhesion (GO:0007155)
negative regulation of peptidase activity (GO:0010466)
positive regulation of protein phosphorylation (GO:0001934)
biological adhesion (GO:0022610)
tube development (GO:0035295)
positive regulation of cellular protein metabolic process (GO:0032270)
tube morphogenesis (GO:0035239)
myeloid cell differentiation (GO:0030099)
regulation of cell-cell adhesion (GO:0022407)
MAPK cascade (GO:0000165)
cellular response to oxygen-containing compound (GO:1901701)
regulation of response to stress (GO:0080134)
positive regulation of protein metabolic process (GO:0051247)
response to abiotic stimulus (GO:0009628)
response to organic cyclic compound (GO:0014070)
regulation of cell differentiation (GO:0045595)
response to organonitrogen compound (GO:0010243)
signal transduction by protein phosphorylation (GO:0023014)
symbiotic process (GO:0044403)
response to other organism (GO:0051707)
negative regulation of response to external stimulus (GO:0032102)
response to external biotic stimulus (GO:0043207)
negative regulation of signal transduction (GO:0009968)
humoral immune response (GO:0006959)
regulation of response to external stimulus (GO:0032101)
negative regulation of cell adhesion (GO:0007162)
negative regulation of cell communication (GO:0010648)
cellular response to organic substance (GO:0071310)
negative regulation of signaling (GO:0023057)
regulation of defense response (GO:0031347)
response to biotic stimulus (GO:0009607)
positive regulation of multicellular organismal process (GO:0051240)
negative regulation of defense response (GO:0031348)
regulation of cell population proliferation (GO:0042127)
kidney development (GO:0001822)
negative regulation of multicellular organismal process (GO:0051241)
tissue development (GO:0009888)
urogenital system development (GO:0001655)
positive regulation of catalytic activity (GO:0043085)
localization of cell (GO:0051674)
cell motility (GO:0048870)
positive regulation of hydrolase activity (GO:0051345)
regulation of phosphorylation (GO:0042325)
renal system development (GO:0072001)
response to nitrogen compound (GO:1901698)
response to radiation (GO:0009314)
positive regulation of immune system process (GO:0002684)
positive regulation of transport (GO:0051050)
interspecies interaction between organisms (GO:0044419)
negative regulation of response to stimulus (GO:0048585)
response to extracellular stimulus (GO:0009991)
regulation of developmental process (GO:0050793)
response to organic substance (GO:0010033)
defense response (GO:0006952)
positive regulation of molecular function (GO:0044093)
positive regulation of signal transduction (GO:0009967)
regulation of MAPK cascade (GO:0043408)
regulation of hemopoiesis (GO:1903706)
positive regulation of signaling (GO:0023056)
cellular response to chemical stimulus (GO:0070887)
defense response to other organism (GO:0098542)
regulation of leukocyte cell-cell adhesion (GO:1903037)
regulation of intracellular signal transduction (GO:1902531)
response to endogenous stimulus (GO:0009719)
blood circulation (GO:0008015)
locomotion (GO:0040011)
response to hormone (GO:0009725)
fatty acid metabolic process (GO:0006631)
positive regulation of cell communication (GO:0010647)
cell surface receptor signaling pathway (GO:0007166)
circulatory system process (GO:0003013)
regulation of T cell activation (GO:0050863)
regulation of hydrolase activity (GO:0051336)
intracellular signal transduction (GO:0035556)
innate immune response (GO:0045087)
chemotaxis (GO:0006935)
taxis (GO:0042330)
regulation of multicellular organismal process (GO:0051239)
positive regulation of response to stimulus (GO:0048584)
regulation of cellular protein metabolic process (GO:0032268)
negative regulation of protein metabolic process (GO:0051248)
skeletal system development (GO:0001501)
regulation of protein metabolic process (GO:0051246)
immune system process (GO:0002376)
vesicle-mediated transport (GO:0016192)
monocarboxylic acid metabolic process (GO:0032787)
regulation of catalytic activity (GO:0050790)
homeostatic process (GO:0042592)
response to external stimulus (GO:0009605)
regulation of response to biotic stimulus (GO:0002831)
regulation of cellular catabolic process (GO:0031329)
supramolecular fiber organization (GO:0097435)
regulation of immune system process (GO:0002682)
animal organ development (GO:0048513)
response to stress (GO:0006950)
movement of cell or subcellular component (GO:0006928)
regulation of localization (GO:0032879)
positive regulation of nitrogen compound metabolic process (GO:0051173)
regulation of immune effector process (GO:0002697)
negative regulation of cellular protein metabolic process (GO:0032269)
regulation of molecular function (GO:0065009)
regulation of signal transduction (GO:0009966)
system development (GO:0048731)
immune response (GO:0006955)
positive regulation of immune response (GO:0050778)
positive regulation of cellular metabolic process (GO:0031325)
regulation of immune response (GO:0050776)
positive regulation of macromolecule metabolic process (GO:0010604)
regulation of transport (GO:0051049)
response to chemical (GO:0042221)
regulation of cell communication (GO:0010646)
regulation of signaling (GO:0023051)
oxoacid metabolic process (GO:0043436)
mitotic cell cycle process (GO:1903047)
cell differentiation (GO:0030154)
positive regulation of metabolic process (GO:0009893)
cellular developmental process (GO:0048869)
cellular response to endogenous stimulus (GO:0071495)
positive regulation of gene expression (GO:0010628)
carboxylic acid metabolic process (GO:0019752)
multicellular organism development (GO:0007275)
organic acid metabolic process (GO:0006082)
anatomical structure development (GO:0048856)
anatomical structure morphogenesis (GO:0009653)
developmental process (GO:0032502)
regulation of biological quality (GO:0065008)
regulation of response to stimulus (GO:0048583)
cell development (GO:0048468)
signal transduction (GO:0007165)
positive regulation of cellular process (GO:0048522)
negative regulation of cellular metabolic process (GO:0031324)
negative regulation of cellular process (GO:0048523)
cell communication (GO:0007154)
signaling (GO:0023052)
localization (GO:0051179)
negative regulation of biological process (GO:0048519)
multicellular organismal process (GO:0032501)
positive regulation of biological process (GO:0048518)
small molecule metabolic process (GO:0044281)
cellular response to stimulus (GO:0051716)
negative regulation of nitrogen compound metabolic process (GO:0051172)
negative regulation of metabolic process (GO:0009892)
organonitrogen compound metabolic process (GO:1901564)
regulation of metabolic process (GO:0019222)
regulation of macromolecule metabolic process (GO:0060255)
regulation of gene expression (GO:0010468)
response to stimulus (GO:0050896)
negative regulation of macromolecule metabolic process (GO:0010605)
organic substance metabolic process (GO:0071704)
metabolic process (GO:0008152)
regulation of cellular process (GO:0050794)
regulation of biological process (GO:0050789)
biological regulation (GO:0065007)
cellular process (GO:0009987)
biological_process (GO:0008150)
Unclassified (UNCLASSIFIED)
 
D

Dimitri001

Experienced Member
My Regimen
Reaction score
340
kawnshawn said:
Can take the FDA from a few months to over a year to approve a new drug depending on a few factors.

Samumed is doing their phase 3 trial outside the US, so pray to god they do their due diligence with finalizing their study competently so that its up to snuff for the FDA's standards.
Click to expand...

Given the cancer risks associated with wnt, their standards better be good.
 
Selb

Selb

Senior Member
My Regimen
Reaction score
637
InBeforeTheCure said:
You should include only 100% matches.

You can run gene ontology enrichment analysis on this site and download the results. I found, using an absolute log2 fold change of at least 0.5, 362 biological processes enriched in the opposite direction in the E2 vs. A.G.A. datasets compared to only 174 in the same direction.

Of the processes enriched in the opposite direction, these are enriched in both the upregulated E2 dataset and downregulated in the A.G.A. dataset:

Code: 
tendon development (GO:0035989)
hair cycle (GO:0042633)
molting cycle (GO:0042303)
cornification (GO:0070268)
collagen fibril organization (GO:0030199)
hair follicle development (GO:0001942)
skin epidermis development (GO:0098773)
hair cycle process (GO:0022405)
molting cycle process (GO:0022404)
skin development (GO:0043588)
keratinization (GO:0031424)
keratinocyte differentiation (GO:0030216)
epidermal cell differentiation (GO:0009913)
ossification (GO:0001503)
epidermis development (GO:0008544)
extracellular matrix organization (GO:0030198)
extracellular structure organization (GO:0043062)
epithelial cell differentiation (GO:0030855)
epithelium development (GO:0060429)
muscle structure development (GO:0061061)
supramolecular fiber organization (GO:0097435)
morphogenesis of an epithelium (GO:0002009)
tissue morphogenesis (GO:0048729)
cell population proliferation (GO:0008283)
tissue development (GO:0009888)
cell death (GO:0008219)
cell adhesion (GO:0007155)
tube morphogenesis (GO:0035239)
programmed cell death (GO:0012501)
biological adhesion (GO:0022610)
circulatory system development (GO:0072359)
cell development (GO:0048468)
animal organ development (GO:0048513)
anatomical structure morphogenesis (GO:0009653)
cell differentiation (GO:0030154)
cellular developmental process (GO:0048869)
system development (GO:0048731)
multicellular organism development (GO:0007275)
regulation of developmental process (GO:0050793)
anatomical structure development (GO:0048856)
developmental process (GO:0032502)
multicellular organismal process (GO:0032501)

These were enriched in the downregulated E2 dataset and upregulated A.G.A. dataset:

Code: 
regulation of transforming growth factor beta production (GO:0071634)
positive regulation of stem cell proliferation (GO:2000648)
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)
response to cadmium ion (GO:0046686)
positive regulation of wound healing (GO:0090303)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
interferon-gamma-mediated signaling pathway (GO:0060333)
positive regulation of tumor necrosis factor production (GO:0032760)
regulation of smooth muscle cell proliferation (GO:0048660)
regulation of leukocyte chemotaxis (GO:0002688)
positive regulation of cysteine-type endopeptidase activity (GO:2001056)
regulation of coagulation (GO:0050818)
positive regulation of interleukin-12 production (GO:0032735)
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)
response to lipopolysaccharide (GO:0032496)
positive regulation of peptidase activity (GO:0010952)
regulation of blood coagulation (GO:0030193)
positive regulation of interleukin-8 production (GO:0032757)
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)
regulation of hemostasis (GO:1900046)
response to molecule of bacterial origin (GO:0002237)
regulation of interleukin-12 production (GO:0032655)
positive regulation of endopeptidase activity (GO:0010950)
regulation of cysteine-type endopeptidase activity (GO:2000116)
extracellular matrix organization (GO:0030198)
extracellular structure organization (GO:0043062)
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)
positive regulation of leukocyte migration (GO:0002687)
cellular response to lipopolysaccharide (GO:0071222)
maternal process involved in female pregnancy (GO:0060135)
positive regulation of chemotaxis (GO:0050921)
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)
regulation of wound healing (GO:0061041)
regulation of fibroblast proliferation (GO:0048145)
cellular response to molecule of bacterial origin (GO:0071219)
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)
negative regulation of epithelial cell proliferation (GO:0050680)
regulation of angiogenesis (GO:0045765)
positive regulation of proteolysis (GO:0045862)
regulation of vasculature development (GO:1901342)
peptide cross-linking (GO:0018149)
cellular response to biotic stimulus (GO:0071216)
positive regulation of smooth muscle cell proliferation (GO:0048661)
response to reactive oxygen species (GO:0000302)
negative regulation of blood vessel morphogenesis (GO:2000181)
negative regulation of vasculature development (GO:1901343)
regulation of response to wounding (GO:1903034)
response to mechanical stimulus (GO:0009612)
regulation of cell-substrate adhesion (GO:0010810)
negative regulation of response to wounding (GO:1903035)
positive regulation of interleukin-6 production (GO:0032755)
regulation of tumor necrosis factor production (GO:0032680)
regulation of cytokine production involved in immune response (GO:0002718)
platelet degranulation (GO:0002576)
myeloid leukocyte migration (GO:0097529)
negative regulation of wound healing (GO:0061045)
regulation of interleukin-8 production (GO:0032677)
antimicrobial humoral response (GO:0019730)
cellular response to acid chemical (GO:0071229)
myeloid leukocyte mediated immunity (GO:0002444)
leukocyte degranulation (GO:0043299)
neutrophil mediated immunity (GO:0002446)
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)
myeloid cell activation involved in immune response (GO:0002275)
leukocyte chemotaxis (GO:0030595)
neutrophil degranulation (GO:0043312)
neutrophil activation involved in immune response (GO:0002283)
cellular response to transforming growth factor beta stimulus (GO:0071560)
positive regulation of leukocyte proliferation (GO:0070665)
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)
leukocyte activation involved in immune response (GO:0002366)
neutrophil activation (GO:0042119)
regulation of leukocyte migration (GO:0002685)
cell activation involved in immune response (GO:0002263)
myeloid leukocyte activation (GO:0002274)
granulocyte activation (GO:0036230)
positive regulation of cell death (GO:0010942)
blood vessel development (GO:0001568)
vasculature development (GO:0001944)
cytokine-mediated signaling pathway (GO:0019221)
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)
antigen processing and presentation of exogenous peptide antigen (GO:0002478)
response to transforming growth factor beta (GO:0071559)
regulation of chemotaxis (GO:0050920)
skin development (GO:0043588)
positive regulation of cytokine production (GO:0001819)
positive regulation of cell adhesion (GO:0045785)
regulation of peptidase activity (GO:0052547)
negative regulation of apoptotic process (GO:0043066)
regulated exocytosis (GO:0045055)
antigen processing and presentation of exogenous antigen (GO:0019884)
response to metal ion (GO:0010038)
cellular response to external stimulus (GO:0071496)
negative regulation of cell death (GO:0060548)
negative regulation of programmed cell death (GO:0043069)
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)
response to fibroblast growth factor (GO:0071774)
regulation of interleukin-6 production (GO:0032675)
regulation of endopeptidase activity (GO:0052548)
response to glucocorticoid (GO:0051384)
antigen processing and presentation of peptide antigen (GO:0048002)
T cell activation (GO:0042110)
protein processing (GO:0016485)
antigen processing and presentation (GO:0019882)
regulation of proteolysis (GO:0030162)
regulation of cell development (GO:0060284)
circulatory system development (GO:0072359)
regulation of epithelial cell proliferation (GO:0050678)
cellular response to lipid (GO:0071396)
response to tumor necrosis factor (GO:0034612)
exocytosis (GO:0006887)
leukocyte mediated immunity (GO:0002443)
leukocyte migration (GO:0050900)
response to lipid (GO:0033993)
cell chemotaxis (GO:0060326)
response to inorganic substance (GO:0010035)
wound healing (GO:0042060)
leukocyte activation (GO:0045321)
regulation of myeloid cell differentiation (GO:0045637)
positive regulation of cell migration (GO:0030335)
response to cytokine (GO:0034097)
secretion by cell (GO:0032940)
response to interferon-gamma (GO:0034341)
cellular response to cytokine stimulus (GO:0071345)
negative regulation of cellular component movement (GO:0051271)
response to corticosteroid (GO:0031960)
export from cell (GO:0140352)
negative regulation of cell migration (GO:0030336)
cellular response to interferon-gamma (GO:0071346)
response to oxygen levels (GO:0070482)
positive regulation of cell motility (GO:2000147)
cellular response to tumor necrosis factor (GO:0071356)
cell activation (GO:0001775)
regulation of cell adhesion (GO:0030155)
regulation of cell death (GO:0010941)
multicellular organismal homeostasis (GO:0048871)
positive regulation of cellular component movement (GO:0051272)
secretion (GO:0046903)
positive regulation of cell-cell adhesion (GO:0022409)
positive regulation of locomotion (GO:0040017)
positive regulation of response to external stimulus (GO:0032103)
regulation of cytokine production (GO:0001817)
negative regulation of cell motility (GO:2000146)
negative regulation of developmental process (GO:0051093)
inflammatory response (GO:0006954)
cell population proliferation (GO:0008283)
regulation of programmed cell death (GO:0043067)
regulation of cell migration (GO:0030334)
regulation of body fluid levels (GO:0050878)
response to ketone (GO:1901654)
immune system development (GO:0002520)
regulation of apoptotic process (GO:0042981)
response to bacterium (GO:0009617)
positive regulation of leukocyte cell-cell adhesion (GO:1903039)
positive regulation of defense response (GO:0031349)
regulation of cell motility (GO:2000145)
response to wounding (GO:0009611)
response to peptide (GO:1901652)
response to virus (GO:0009615)
hematopoietic or lymphoid organ development (GO:0048534)
negative regulation of cell population proliferation (GO:0008285)
positive regulation of developmental process (GO:0051094)
immune effector process (GO:0002252)
regulation of leukocyte proliferation (GO:0070663)
positive regulation of intracellular signal transduction (GO:1902533)
positive regulation of T cell activation (GO:0050870)
hemopoiesis (GO:0030097)
response to growth factor (GO:0070848)
regulation of locomotion (GO:0040012)
cellular response to growth factor stimulus (GO:0071363)
positive regulation of immune effector process (GO:0002699)
regulation of cellular component movement (GO:0051270)
negative regulation of endopeptidase activity (GO:0010951)
regulation of anatomical structure morphogenesis (GO:0022603)
response to steroid hormone (GO:0048545)
regulation of multicellular organismal development (GO:2000026)
negative regulation of proteolysis (GO:0045861)
negative regulation of locomotion (GO:0040013)
positive regulation of phosphorylation (GO:0042327)
negative regulation of cell differentiation (GO:0045596)
positive regulation of cell differentiation (GO:0045597)
regulation of inflammatory response (GO:0050727)
cell migration (GO:0016477)
positive regulation of cell population proliferation (GO:0008284)
response to oxygen-containing compound (GO:1901700)
cell adhesion (GO:0007155)
negative regulation of peptidase activity (GO:0010466)
positive regulation of protein phosphorylation (GO:0001934)
biological adhesion (GO:0022610)
tube development (GO:0035295)
positive regulation of cellular protein metabolic process (GO:0032270)
tube morphogenesis (GO:0035239)
myeloid cell differentiation (GO:0030099)
regulation of cell-cell adhesion (GO:0022407)
MAPK cascade (GO:0000165)
cellular response to oxygen-containing compound (GO:1901701)
regulation of response to stress (GO:0080134)
positive regulation of protein metabolic process (GO:0051247)
response to abiotic stimulus (GO:0009628)
response to organic cyclic compound (GO:0014070)
regulation of cell differentiation (GO:0045595)
response to organonitrogen compound (GO:0010243)
signal transduction by protein phosphorylation (GO:0023014)
symbiotic process (GO:0044403)
response to other organism (GO:0051707)
negative regulation of response to external stimulus (GO:0032102)
response to external biotic stimulus (GO:0043207)
negative regulation of signal transduction (GO:0009968)
humoral immune response (GO:0006959)
regulation of response to external stimulus (GO:0032101)
negative regulation of cell adhesion (GO:0007162)
negative regulation of cell communication (GO:0010648)
cellular response to organic substance (GO:0071310)
negative regulation of signaling (GO:0023057)
regulation of defense response (GO:0031347)
response to biotic stimulus (GO:0009607)
positive regulation of multicellular organismal process (GO:0051240)
negative regulation of defense response (GO:0031348)
regulation of cell population proliferation (GO:0042127)
kidney development (GO:0001822)
negative regulation of multicellular organismal process (GO:0051241)
tissue development (GO:0009888)
urogenital system development (GO:0001655)
positive regulation of catalytic activity (GO:0043085)
localization of cell (GO:0051674)
cell motility (GO:0048870)
positive regulation of hydrolase activity (GO:0051345)
regulation of phosphorylation (GO:0042325)
renal system development (GO:0072001)
response to nitrogen compound (GO:1901698)
response to radiation (GO:0009314)
positive regulation of immune system process (GO:0002684)
positive regulation of transport (GO:0051050)
interspecies interaction between organisms (GO:0044419)
negative regulation of response to stimulus (GO:0048585)
response to extracellular stimulus (GO:0009991)
regulation of developmental process (GO:0050793)
response to organic substance (GO:0010033)
defense response (GO:0006952)
positive regulation of molecular function (GO:0044093)
positive regulation of signal transduction (GO:0009967)
regulation of MAPK cascade (GO:0043408)
regulation of hemopoiesis (GO:1903706)
positive regulation of signaling (GO:0023056)
cellular response to chemical stimulus (GO:0070887)
defense response to other organism (GO:0098542)
regulation of leukocyte cell-cell adhesion (GO:1903037)
regulation of intracellular signal transduction (GO:1902531)
response to endogenous stimulus (GO:0009719)
blood circulation (GO:0008015)
locomotion (GO:0040011)
response to hormone (GO:0009725)
fatty acid metabolic process (GO:0006631)
positive regulation of cell communication (GO:0010647)
cell surface receptor signaling pathway (GO:0007166)
circulatory system process (GO:0003013)
regulation of T cell activation (GO:0050863)
regulation of hydrolase activity (GO:0051336)
intracellular signal transduction (GO:0035556)
innate immune response (GO:0045087)
chemotaxis (GO:0006935)
taxis (GO:0042330)
regulation of multicellular organismal process (GO:0051239)
positive regulation of response to stimulus (GO:0048584)
regulation of cellular protein metabolic process (GO:0032268)
negative regulation of protein metabolic process (GO:0051248)
skeletal system development (GO:0001501)
regulation of protein metabolic process (GO:0051246)
immune system process (GO:0002376)
vesicle-mediated transport (GO:0016192)
monocarboxylic acid metabolic process (GO:0032787)
regulation of catalytic activity (GO:0050790)
homeostatic process (GO:0042592)
response to external stimulus (GO:0009605)
regulation of response to biotic stimulus (GO:0002831)
regulation of cellular catabolic process (GO:0031329)
supramolecular fiber organization (GO:0097435)
regulation of immune system process (GO:0002682)
animal organ development (GO:0048513)
response to stress (GO:0006950)
movement of cell or subcellular component (GO:0006928)
regulation of localization (GO:0032879)
positive regulation of nitrogen compound metabolic process (GO:0051173)
regulation of immune effector process (GO:0002697)
negative regulation of cellular protein metabolic process (GO:0032269)
regulation of molecular function (GO:0065009)
regulation of signal transduction (GO:0009966)
system development (GO:0048731)
immune response (GO:0006955)
positive regulation of immune response (GO:0050778)
positive regulation of cellular metabolic process (GO:0031325)
regulation of immune response (GO:0050776)
positive regulation of macromolecule metabolic process (GO:0010604)
regulation of transport (GO:0051049)
response to chemical (GO:0042221)
regulation of cell communication (GO:0010646)
regulation of signaling (GO:0023051)
oxoacid metabolic process (GO:0043436)
mitotic cell cycle process (GO:1903047)
cell differentiation (GO:0030154)
positive regulation of metabolic process (GO:0009893)
cellular developmental process (GO:0048869)
cellular response to endogenous stimulus (GO:0071495)
positive regulation of gene expression (GO:0010628)
carboxylic acid metabolic process (GO:0019752)
multicellular organism development (GO:0007275)
organic acid metabolic process (GO:0006082)
anatomical structure development (GO:0048856)
anatomical structure morphogenesis (GO:0009653)
developmental process (GO:0032502)
regulation of biological quality (GO:0065008)
regulation of response to stimulus (GO:0048583)
cell development (GO:0048468)
signal transduction (GO:0007165)
positive regulation of cellular process (GO:0048522)
negative regulation of cellular metabolic process (GO:0031324)
negative regulation of cellular process (GO:0048523)
cell communication (GO:0007154)
signaling (GO:0023052)
localization (GO:0051179)
negative regulation of biological process (GO:0048519)
multicellular organismal process (GO:0032501)
positive regulation of biological process (GO:0048518)
small molecule metabolic process (GO:0044281)
cellular response to stimulus (GO:0051716)
negative regulation of nitrogen compound metabolic process (GO:0051172)
negative regulation of metabolic process (GO:0009892)
organonitrogen compound metabolic process (GO:1901564)
regulation of metabolic process (GO:0019222)
regulation of macromolecule metabolic process (GO:0060255)
regulation of gene expression (GO:0010468)
response to stimulus (GO:0050896)
negative regulation of macromolecule metabolic process (GO:0010605)
organic substance metabolic process (GO:0071704)
metabolic process (GO:0008152)
regulation of cellular process (GO:0050794)
regulation of biological process (GO:0050789)
biological regulation (GO:0065007)
cellular process (GO:0009987)
biological_process (GO:0008150)
Unclassified (UNCLASSIFIED)
Click to expand...

This is awesome, great work. There’s a lot here, so we’d need to filter it out even more, but it goes to show you how substantial the effect estrogen has on hair growth.

Edit: maybe we should also move this to a different thread
 
T

Tom4362

Established Member
My Regimen
Reaction score
513
@pegasus2 what is your opinion of KY-19382? Also, is this something the labs can produce before it is approved?
If the first human trials (which is planned for next year) shows it's safe this might be interesting
 
P

pegasus2

Senior Member
My Regimen
Reaction score
4,504
Tom4362 said:
@pegasus2 what is your opinion of KY-19382? Also, is this something the labs can produce before it is approved?
If the first human trials (which is planned for next year) shows it's safe this might be interesting
Click to expand...

It's an indirubin derivative, easy and cheap to synthesize if you can find someone willing to do it. It's one of the more promising treatments being developed.
 
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