Ru58841 - The Popular Alternative To Finasteride | HairLossTalk Forums

Ru58841 - The Popular Alternative To Finasteride

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by Admin, Jan 23, 2017.

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  1. Admin

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    What is RU58841 (PSK-3841)?



    RU58841 was developed as a topical treatment for hair loss, hirsutism and acne. Although RU58841 has never been commercialized, it has gained popularity as a treatment worldwide primarily for hair loss.

    Why is RU58841 sold as a research chemical?
    RU58841 is only available as a research chemical because it has not been approved. Although it is being sold in Indonesia over the counter under the name “mezogenrx”, which is a combination of minoxidil & RU58841.

    ru58841-a.jpg


    Have human clinical trials ran with RU58841?

    Yes, a company named Prostrakan ran clinical trials with RU58841. The first clinical trial consisted of a 5% topical solution administered twice daily for 4 weeks to a total of 30 people. The second clinical trial was done over a time period of 6 months with a 2.5% and a 5% solution in 120 people. They also performed a clinical proof of concept study for acne.

    After the second clinical trial, they put out this statement which mentions that the data compared to finasteride:

    “PSK 3841 ProSkelia partnering opportunity, Worldwide Partners are sought by ProSkelia for the development of PSK 3841. Neil Brown, Vice President of Licensing and Acquisitions at ProSkelia, announced during a presentation at BioSquare PSK 3841, a nonsteroidal antiandrogen has completed Phase IIa trials for the treatment of androgenetic alopecia and a clinical proof-of-concept study to reduce sebum flow and secretion in patients with acne. Six months of treatment with PSK 3481 demonstrated equivalent or better net hair growth compared with finasteride”

    Why has RU58841 never been commercialized?
    Nobody knows. What is interesting is that the market for RU8841 was believed to be “modest” in a report of Morgan & Stanley:

    “ProStrakan’s topical androgen receptor antagonist has completed a Phase IIa proof-of-concept study for alopecia. In this trial, which was not powered for efficacy, there was an observed increase in both new and existing hair growth and the data compared well with historical data for finasteride (marked by Merck as propecia). We believe the market for this agent is reasonably modest – US $100 – 200 million – but that could be of interest to a specialty dermatology company. With partnering discussions ongoing we believe that a deal could be announced next year”

    Secondly, RU58841 didn’t have much time left because the patent was almost expired. So it could have been because of financial reasons.

    ru58841-b.jpg


    How do most people use RU58841 for their research?

    Most buy RU58841 either as a ready-made solution or they buy the powder and make their own solution. Typically it is used in a 5% concentration.

    Where can I buy RU58841 for research?
    This supplier sells RU58841 with a high purity of 99% in a ready-made solution and in a powder form to make your own solution. http://www.anageninc.com

    ru58841-c.jpg

    Testing and Purity Verification:

    This supplier tests each batch in a third-party Government-controlled lab. Check the test reports:
    http://anageninc.com/media/lab test.zip

    Additional information:

    http://www.ru-58841.com/what-is-ru58841/

    http://www.isrctn.com/ISRCTN7108377...=2&page=1&pageSize=10&searchType=basic-search

    http://www.isrctn.com/ISRCTN49873657

    https://www.ncbi.nlm.nih.gov/pubmed/8136306

    https://www.ncbi.nlm.nih.gov/pubmed/9415227

    https://www.ncbi.nlm.nih.gov/pubmed/9798729

    https://www.ncbi.nlm.nih.gov/pubmed/7625751
     
    bobhead, GoldenMane, kj6723 and 5 others like this.
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