No,Why would there be an adverse reaction? minoxidil is minoxidil....I would go with docter lee"s xandrox cuz it also has alziac acid in it which kills dht on contact so u gettin a two for one deal with the xandrox(which I am currently on) cuz remember the mino is a hair stimulant,u also need to supress dht in the hair which chokes the folicle