Update:
RIKEN is accepting donations here to help them move forward with clinical trials in humans. They have already completed a preclinical safety test in a human, and received regulatory approval to begin clinical trials.
Update 2:
Expansion and characterization of epithelial stem cells with potential for cyclical hair regeneration
RIKEN is accepting donations here to help them move forward with clinical trials in humans. They have already completed a preclinical safety test in a human, and received regulatory approval to begin clinical trials.
Update 2:
regenerated hair grew from the skin of the mouse on the 21st day of transplantation, and the arrector pili muscle and nerve fibers were connected in the same manner as natural hair, and it was normal.
We controlled the number of regenerated hair follicles by controlling the size of the regenerated hair follicle primordium. In this way, it was possible to change the density at the time of transplantation and regenerate with a density of 124 hairs per square centimeter, which is equivalent to human hair.
Since "hair follicle regenerative medicine" uses somatic stem cells isolated from the patient's own hair follicles, it falls under "type 2 regenerative medicine, etc." and is approved by the Specified Certified Regenerative Medicine Committee and the Minister of Health, Labor and Welfare
With the funding of clinical research, the research can be started within a year. The first target is androgenetic alopecia, whose mechanism is clear, and the period will be about one and a half years.
If this clinical study reveals its safety and efficacy, it can be implemented in society as a paid clinical study.
薄毛の悩みに“希望の光”…! 髪の毛を再生する「研究最前線」は“ここまで”来ている!(辻 孝) @gendai_biz
人類にとって悩みの1つである「薄毛」や「脱毛症」。再生医療の技術を使ってその“難題”に挑む研究の「現在地」は…
gendai.ismedia.jp
https://eurekalert.org/pub_releases/2021-02/r-arf021021.phpThe researchers took fur and whisker cells from mice and cultured them in the laboratory with other biological "ingredients". They used 220 combinations of ingredients, and found that combining a type of collagen with five factors--the NFFSE medium--led to the highest rate of stem cell amplification in the shortest period of time..
To test whether stem cells cultured in the NFFSE medium produce hair that cycles, the researchers placed bioengineered hair follicle stem cells in NFFSE medium or in medium missing one of the ingredients and observed the regenerated hair for several weeks. They found 81% of hair follicles generated in NFFSE medium went through at least three hair cycles and produced normal hair. In contrast, 79% of follicles grown in the other medium produced only one hair cycle.
Knowing that stem-cell renewal can depend on what is attached to the outside of the cells, the researchers next looked for markers on the surface of cells cultured in the NFFSE medium. In addition to the expected CD34 and CD49f markers, they found the best hair cycling was related to the addition of Itgβ5. "We found almost 80% of follicles reached three hair cycles when Itgβ5 was also bioengineered into the hair follicle germ," explains first author Makoto Takeo. "In contrast, only 13% reached three cycles when it was not present." Analysis showed that these important cells are naturally located in the upper part of the hair follicle's bulge region.
"Our culture system establishes a method for cyclical regeneration of hair follicles from hair follicle stem cells," says Tsuji, "and will help make hair follicle regeneration therapy a reality in the near future." As preclinical animal-safety tests using these cultured cells were completed in 2019, the next step in the process is clinical trials.
"RIKEN is primarily an institute that does basic research," explains Tsuji. "And clinical trials usually require outside collaborators. We are therefore looking for a partner company to help develop the clinical applications and welcome donations to promote the R&D."
Expansion and characterization of epithelial stem cells with potential for cyclical hair regeneration
However, a venture capital firm that was supposed to provide financial support has stopped operations for economic reasons. That forced the scientists to start a fund-raising drive on Feb. 10 to fund the clinical tests.
The team is seeking 500 million yen ($4.8 million) in donations from companies and individuals. The money will be used not only for clinical testing on the safety of the hair transplant technology, but also for other trials, such as regenerating teeth.
http://www.asahi.com/ajw/articles/14181974The safety of the technology has already been confirmed through testing on animals, and the team had gained approval to begin human clinical testing when its business partner could not proceed with development.
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