RIKEN Announcement: Succeeded in Developing Tech for HF Regenerative Medicine: Study to be Published Feb 10

[frank33]

but only on mice. That doesn't impress me too much. Many then failed.
but basically you are right.

Hopefully this is the last time we hear from Riken about mice.
But now we know hair cloning is a thing, it is possible and the next step will be testing it on humans.
The fact alone Tsuji is still on track, so that we have two legit companies determined to pursue hair cloning is great.
It's not about how and if anymore, but when.

 

[Pls_NW-1]

Hopefully this is the last time we hear from Riken about mice.
But now we know hair cloning is a thing, it is possible and the next step will be testing it on humans.
The fact alone Tsuji is still on track, so that we have two legit companies determined to pursue hair cloning is great.
It's not about how and if anymore, but when.

Probably in 5 years lol

 

[Pls_NW-1]

I do think that cloning is not anymore a science fiction thing when it comes down to hair, but it's not something we might experience in the near future, it's not something like others say; around the corner. I don’t want to sound like a pessimst, but humans, especially scientists, aren't god, maybe in movies, but not in reality.

Scrap that idea out of your mind; Stemson,... Tsuji,... for now, maybe later.

 

[Shush]

I don't know what part of the " we are ready to start human trials " you boys don't understand

 

[Pls_NW-1]

I don't know what part of the " we are ready to start human trials " you boys don't understand

Didn't they said that a year ago as well!? I see you are not on treatment. I would recommend taking action, than waiting for news, really.

 

[Throwaway94]

The point here is the breakthrough in the age old inductivity issue. They now have a culture medium that allows the cloned hairs to maintain their ability to recruit stem cells once they've been transplanted and thereby maintain hair cycling.

Replicel / HairClone / whoever else could learn from this, their cell expansion treatments all bank on the cells retaining their ability to recruit and induce HFSC differentiation and haven't quite succeeded.

 

[Shush]

Didn't they said that a year ago as well!? I see you are not on treatment. I would recommend taking action, than waiting for news, really.

What does me being on treatment have to do with this? It was all speculations before plus something a random youtuber said. What changed is that they publicly stated they have the technology and they are ready to test it

 

[MrV88]

but only on mice. That doesn't impress me too much. Many then failed.
but basically you are right.

The difference, maybe the only one until now, is that it was human hair in mice, but they seem to grow anything.

Regarding the funding of approximately 5 mil $ this treatment shouldn't be that expensive? No information about how many subjects they need or plan to treat etc. ?

 

[TurboFixer]

completes 3 hair cycles over 80% of the time? So assuming a hair cycle is 2 - 6 years that means that 80% will last a minimum of 6 years?

 

[Throwaway94]

completes 3 hair cycles over 80% of the time? So assuming a hair cycle is 2 - 6 years that means that 80% will last a minimum of 6 years?

They're referring to the mouse hair cycle of a couple of weeks. In theory yes this would correspond to our 5 year hair cycle but the take home point is that the cells showed an ability to recruit stem cells in vivo and thereby renew the cycle.

 

[Pls_NW-1]

A little reminder: yuu cant translate mouse studies on humans.

Great qoute of a member from another thread: "you can rub a brick on a mouse, and hair will grow out" lol

 

[Pls_NW-1]

a study on monkeys and pigs would have been very helpful. Then another where you checked the hair thickness, density, Hair color, direction of growth, etc. In addition, a long-term follow-up of 24 months. That would have been great

Agreed!

 

[TanDoc]

Donations being sought for Riken clinical testing to cure baldness | The Asahi Shimbun: Breaking News, Japan News and Analysis

www.asahi.com

Very interestjng article
They need 4.8M Dollar.

The team is seeking 500 million yen ($4.8 million) in donations from companies and individuals. The money will be used not only for clinical testing on the safety of the hair transplant technology, but also for other trials, such as regenerating teeth.

“Transplanting follicles has the advantages of not being life-threatening and easily removable if something went wrong since it would be placed on the skin surface," said team leader Takashi Tsuji. "We are asking for support in our research and development because this is a problem concerning a wide part of the population and because this could lead to promoting a new industry from Japan.”

"They will first conduct clinical testing on bald men because the mechanism for that condition is better understood."


The safety of the technology has already been confirmed through testing on animals, and the team had gained approval to begin human clinical testing when its business partner could not proceed with development.

If they are actually seeking small-scale donations, they should hit up western media sources of all kinds (from Reuters/AP all the way to the New York Post/Daily Mail). And set up an English-language donation portal. They'd get (and even surpass) their $4.8 million easily.

 

[frank33]

A little reminder: yuu cant translate mouse studies on humans.

Great qoute of a member from another thread: "you can rub a brick on a mouse, and hair will grow out" lol

Actually you can, you are not certain it will work, but many times it just does.
Treatments for androgenic alopecia have a hard time being consistent between mice and humans because this is a disease that just doesen't show in them.
However, Tsuji's research is about hair cloning, and not some treatment for Androgenetic Alopecia, so i think there's a higher chance that findings will be consistent.
Remember that if a molecule doesen't show efficacy, there's not much you can do, but with hair cloning they will be able to adjust and gradually find the optimal process.

 

[frank33]

Yup, I wonder if the result will be the same when apllied to humans.

I'll only be excited and legit hyped if their first human trial is successful but for now I'm cautiously optimistic.

That's a respectable attitude.

 

[MeDK]

Actually you can, you are not certain it will work, but many times it just does.
Treatments for androgenic alopecia have a hard time being consistent between mice and humans because this is a disease that just doesen't show in them.
However, Tsuji's research is about hair cloning, and not some treatment for Androgenetic Alopecia, so i think there's a higher chance that findings will be consistent.
Remember that if a molecule doesen't show efficacy, there's not much you can do, but with hair cloning they will be able to adjust and gradually find the optimal process.

that is simply not true, and it is not only for androgenic alopecia where its near impossible to direct translations from mice studies into human studies.

If it was, MANY diseases would have been cured decades ago. You wouldn't believe how many diseases you can cure in a mouse study, and it have been criticized within the medical field too.

Why do they use mouse study then, because not its not so popular to have a chimpanzee in the lab. People rarely care for mice and they have a relative short lifespan and is just an unpopular animal in generel in many nations around the world. Mice is also cheap and breed pretty fast and you can do many gene alterations to them. the ethics around mice is almost non-existent.

 

[Pls_NW-1]

Yup, I wonder if the result will be the same when apllied to humans.

I'll only be excited and legit hyped if their first human trial is successful but for now I'm cautiously optimistic.

Very true! There is no point to hype up, and being again dissapointed.

 

[frank33]

that is simply not true, and it is not only for androgenic alopecia where its near impossible to direct translations from mice studies into human studies.

If it was, MANY diseases would have been cured decades ago. You wouldn't believe how many diseases you can cure in a mouse study, and it have been criticized within the medical field too.

Why do they use mouse study then, because not its not so popular to have a chimpanzee in the lab. People rarely care for mice and they have a relative short lifespan and is just an unpopular animal in generel in many nations around the world. Mice is also cheap and breed pretty fast and you can do many gene alterations to them. the ethics around mice is almost non-existent.

Did i say it is 100% certain mice studies will translate to humans?
As i said, even though i think, COMPARED TO Androgenetic Alopecia TREATMENTS, there will be a higher chance of success, in any case they will be able to adjust their findings, not like with drugs that either work or don't.

 

[MeDK]

Did i say it is 100% certain mice studies will translate to humans?
As i said, even though i think, COMPARED TO Androgenetic Alopecia TREATMENTS, there will be a higher chance of success, in any case they will be able to adjust their findings, not like with drugs that either work or don't.

Well the problem with mice study is that the mice is used have modified genes, like no immune defense and things like that, then you can do almost anything do a mouse and things will happen.

But since humans have immune defense, then its quite hard to work around. Because the immune defense does what it can do remove what attacks the body, the body even starts to compensate for on going treatments. That is why its more interesting to see long term treatments and clinical trails, so we know if the body starts to fight and compensate for the treatment.

And when overcome the immune defense problem, then there is the blood flow, will humans be able to re-create that blood flow?

Many here have big dreams about high density hair, and it have shown that if you just re-create high density hair again, then it will die out because of the lack of blood flow.

I'm all in for RIKEN way to move forward.

But i'm simply more interested in the long term, and if they actually can make it work, this is also why i'm more of a fan boy to the Replicel approach with regeneration. To me that seems to be more approachable, than doing maybe 10.000 nylon strings into the scalp and hope for the best in the long term.

But let us see how it goes with RIKEN, and their first proof of concept in humans, or their first phase 1. Would be great with a 24 months study or more.

 

[Pls_NW-1]

@MeDK
Your opinion to Stemson?

I'm also quite interested into that.
Stemson gives out many "promises" on interviews, presentations, websites etc... it remains unproven however.