Restoring Wnt/β-catenin Signaling Is A Promising Therapeutic Strategy

John Difool

Senior Member
My Regimen
I think that if SM04554 only was a GSK3B inhibitor dont work... For example, I dont know anyone who had results with VPA

From the company website:

SM04690 treatment decreased the expression of Wnts signaling activators and downstream genes, e.g. Wnt3a, Dvl, Axin2, TCF4, TCF7, APC. GSK3β, CyclinD1 etc. as compared to vehicle

SM04690 treatment increased the expression of Wnt pathway inhibitors e.g. DKK1, 2, WIF1 etc. as compared to vehicle.
 

tomJ

Senior Member
My Regimen
Thanks for providing some background. If your medical condition stops you from experimenting with new treatments (I am sorry to hear that), what makes you think that upcoming hair treatments will be applicable to your condition? It seems that even FDA approved treatments are always denied to people with medical conditions.
I have no idea if the new treatments will affect my health or not. I'm actually very anxious about that being a string possibility. I am hopeful because that's all I can be right now. And also I'd rather take a chance with an FDA approved drug as opposed to a chinese lab unapproved chemical. No brainer.
 

tomJ

Senior Member
My Regimen
I have had some minor regrowth and decent thickening from wounding with a post wound topical of 5% minoxidil, 10mg/ml LiCi, and 0.075% capsaicin. No way of telling how much is due to the LiCi of course, but wanted to share.
Aw man I wish u would have tried it with LiCi first! But I'm happy for you.
 

John Difool

Senior Member
My Regimen
What's the adequate dosage with lithium chloride topical?

Buy 99% Lithium Chloride powder (100g) . Measure the powder to get the 10 or 20 milligrams to mix with the 1 mL vehicle, either ethanol or water work.

EDIT: milligrams not grams.
 
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wislow9

Established Member
My Regimen
From the company website:

SM04690 treatment decreased the expression of Wnts signaling activators and downstream genes, e.g. Wnt3a, Dvl, Axin2, TCF4, TCF7, APC. GSK3β, CyclinD1 etc. as compared to vehicle

SM04690 treatment increased the expression of Wnt pathway inhibitors e.g. DKK1, 2, WIF1 etc. as compared to vehicle.

SM04690 its not related with SM04554
This big company works in several projects
 

pegasus2

Senior Member
My Regimen
Has anyone an opinion on FK506 ?

Not really. It's an mTOR inhibitor I think. What is your interest in it?

edit: It inhibits TNF-a and IL-1b

Interesting. Are you going to try it? It's actually one of the alternative compounds listed in Follica's patent. It's tempting to use it, but combining this with upregulating Hh and Wnts is a recipe for disaster.

https://www.alldaychemist.com/talimus-01.html $17.
 
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pegasus2

Senior Member
My Regimen
@pegasus2 What do you think about Samumed an their upcoming treatment?

Minoxidil without the sides. In other words, it won't stop the balding process, but increase the number of hairs on your head so you go bald a couple years later. It's no big leap forward, but maybe in combination with things like wounding it will do more.
 

sonictemples

Experienced Member
My Regimen
If anyone is interested in trying gallocyanine (IIIc3) as a dkk1 inhibitor, it's potent, dirt cheap, and soluble in anything. The only problem is that it's not stable in solution so you'll have to make it fresh every day. On the bright side the powder is stable at room temperature for months, so you don't have to take it in and out of the freezer every day. It only takes a couple minutes a day to put a couple ml of minoxidil or stemoxydine in a separate bottle and then shake it up. @whatevr This might be easier for you than making MAP liposomes. It isn't quite as effective a Wnt agonist as WAY-262611, but it's close, and the cost is only around $5/mo. compared with $500/mo. for WAY-262611.

View attachment 142508

https://dev.biologists.org/content/develop/144/20/3819.full.pdf?with-ds=yes
Please update on this, thank you!
 
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