Replicel Is On Fire Lately — Data In Feb.

Spanishboy97

Established Member
My Regimen
No your opinion was based on unrealistic expectations. "Omg it didn't turn a NW5 in a NW1, Such a fail bro!"

Mine is based on reality.

"We are very pleased that the data from this randomized, placebo-controlled, double-blinded, dose-ranging clinical study of 65 patients (male and female) with pattern hair loss confirms, with statistical significance, the observations from our ph 1 trial in a larger cohort of patients including females, a wide variety of ages and hair loss, and compared with a placebo-control. In summary, the study produced a statistically significant and clinically meaningful increase in hair density and diameter as measured nine months after treatment,” stated RepliCel’s Chief Medical Officer, Dr. Rolf Hoffman.

Btw, shiseido updated their site in february this year, let's look what they say:

In recent years, technology has evolved remarkably, particularly in the development of digital technology and various devices that are greatly changing our lives. We apply these technological trends using our strengths to offer personalization and e-commerce counseling which allow customers to choose the skincare and makeup items that suit them without going to a store.
We also pursue hair regenerative medicine and create new beauty solutions that support skin health and beauty from the inside through food.

https://corp.shiseido.com/en/rd/development/

Now let's read the conclusions of the actual new study:

https://www.sciencedirect.com/science/article/abs/pii/S0190962220302723

Conclusion
The results suggest that cell therapy with autologous DSC cells may be useful as a new therapeutic method for treating MPHL and FPHL.


"Bu..bu it's not coming out bro, they couldn't regrow a NW5 to NW1! Complete failure bro!"
To be fair it wont make a Nw3 a Nw2 either
 

MrV88

Senior Member
My Regimen
True, but maintenance even for 6 months alone without f*****g with your hormones is a miracle imo.
Ain't the problem that you need about 50-100 grafts for a treatment and it this just lasts just 9 months instead of forever, like Replicel said in the first place?. So you would lose hair just to maintain the rest. And you have to fly to Japan, take the biopsy, fly back, wait and fly again to Tokyo for this crap.

This sh*t is done in my eyes, sad that it won't last forever.
 

pegasus2

Senior Member
My Regimen
True, but maintenance even for 6 months alone without f*****g with your hormones is a miracle imo.
You have to be trolling. Nobody cares about having the same amount of hair for 6 months longer. Minoxidil maintains for 2 years without touching your hormones. CB maintains for over a year without any side effects. Stemoxydine and redensyl maintain for 6 months. There are tons of things that maintain your hair for 6 months including doing absolutely nothing. Even the control group's 6 month loss is so minimal you wouldn't notice it.
 

Hswb

New Member
My Regimen
You have to be trolling. Nobody cares about having the same amount of hair for 6 months longer. Minoxidil maintains for 2 years without touching your hormones. CB maintains for over a year without any side effects. Stemoxydine and redensyl maintain for 6 months. There are tons of things that maintain your hair for 6 months including doing absolutely nothing. Even the control group's 6 month loss is so minimal you wouldn't notice it.

Speak for yourself. I DO care about keeping the same hair for 6 months, as long as the procedure is any affordable. The problem is, that the maintainance drugs you mention are all temporary. For me, minoxidil and duta did its work and lost all its efficiency. Now I’m slowly going back to baseline, after 7 years of insanely good results.

The amount of hair I still have today, is (almost) good enough for me. With a small transplant + a sideless maintainance therapy which doesn’t lose effect over time, in theory I’m settled for life!

the big question is: will this procedure also lose its effect over time, same as all the other maintainance therapies?
 

Throwaway94

Experienced Member
My Regimen
You have to be trolling. Nobody cares about having the same amount of hair for 6 months longer. Minoxidil maintains for 2 years without touching your hormones. CB maintains for over a year without any side effects. Stemoxydine and redensyl maintain for 6 months. There are tons of things that maintain your hair for 6 months including doing absolutely nothing. Even the control group's 6 month loss is so minimal you wouldn't notice it.

There's still the fact that it's a one-and-done, no daily topicals. That adds a layer of freedom to your life. There also doesn't seem to be "catch up loss" if you stop like with minoxidil or finasteride.

Ain't the problem that you need about 50-100 grafts for a treatment and it this just lasts just 9 months instead of forever, like Replicel said in the first place?. So you would lose hair just to maintain the rest. And you have to fly to Japan, take the biopsy, fly back, wait and fly again to Tokyo for this crap.

This sh*t is done in my eyes, sad that it won't last forever.

The grafts they take are enough for a lifetime of treatments. That's what the frozen storage in Shiseido's cell processing centre is for.
 

pegasus2

Senior Member
My Regimen
Speak for yourself. I DO care about keeping the same hair for 6 months, as long as the procedure is any affordable. The problem is, that the maintainance drugs you mention are all temporary. For me, minoxidil and duta did its work and lost all its efficiency. Now I’m slowly going back to baseline, after 7 years of insanely good results.

The amount of hair I still have today, is (almost) good enough for me. With a small transplant + a sideless maintainance therapy which doesn’t lose effect over time, in theory I’m settled for life!

the big question is: will this procedure also lose its effect over time, same as all the other maintainance therapies?

Shiseido is temporary too. That's the point. My post that you replied to was in reference to Pigeon's assertion that a treatment which maintains for 6 months without messing with his hormones is a miracle. Nothing you just said is relevant to that point.


There's still the fact that it's a one-and-done, no daily topicals. That adds a layer of freedom to your life. There also doesn't seem to be "catch up loss" if you stop like with minoxidil or finasteride.



The grafts they take are enough for a lifetime of treatments. That's what the frozen storage in Shiseido's cell processing centre is for.

Except it's not "one-and-done". That's the whole point. Do you agree with Pigeon that it's a miracle if you have to fly to Japan every six months for this "one-and-done" treatment? I don't. There's also no evidence that there isn't "catch up loss" with this, nor is there any evidence that there is "catch up loss" with finasteride. You're going to spend more time and money just on the flight to Japan than you will in six months applying topicals, so that's not a good argument.

Where is your source that one biopsy will be used to cover two treatments per year for the rest of your life? A cell processing center having frozen storage doesn't even prove that they are storing your cells after the treatment, let alone that they will store them for you in perpetuity, free of charge. People aren't being realistic with this treatment.
 
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Throwaway94

Experienced Member
My Regimen
Except it's not "one-and-done". That's the whole point. Do you agree with Pigeon that it's a miracle if you have to fly to Japan every six months for this "one-and-done" treatment? I don't. There's also no evidence that there is "catch up loss" with this, nor is there any evidence that there is "catch up loss" with finasteride. You're going to spend more time and money just on the flight to Japan than you will in six months applying topicals, so that's not a good argument.

Where is your source that one biopsy will be used to cover two treatments per year for the rest of your life? A cell processing center having frozen storage doesn't even prove that they are storing your cells after the treatment, let alone that they will store them for you in perpetuity, free of charge. People aren't being realistic with this treatment.

I didn't suggest there would be catch up loss with this, rather the opposite if it works the way it's meant to, but it's very well documented for finasteride.

It's a one and done for six months at a time. I don't know about miracle but it's an excellent addition for people in Japan, and then the rest of us when / if it becomes available locally, which this would help pave the way for.

No one suggested that storage would be free of charge, it's likely a fee but that's irrelevant. My source is the fact that they have the storage facility and the dilution they use to reach treatment concentration, there is enough there for a lifetime and would be completely ridiculous to dispose of it and demand new grafts every time. You can call it conjecture if you like but the capability is there and it makes absolutely no sense not use it.
 

pegasus2

Senior Member
My Regimen
I didn't suggest there would be catch up loss with this, rather the opposite if it works the way it's meant to, but it's very well documented for finasteride.

It's a one and done for six months at a time. I don't know about miracle but it's an excellent addition for people in Japan, and then the rest of us when / if it becomes available locally, which this would help pave the way for.

No one suggested that storage would be free of charge, it's likely a fee but that's irrelevant. My source is the fact that they have the storage facility and the dilution they use to reach treatment concentration, there is enough there for a lifetime and would be completely ridiculous to dispose of it and demand new grafts every time. You can call it conjecture if you like but the capability is there and it makes absolutely no sense not use it.

I mean there's no evidence that there isn't catch up loss with this. This won't be available in the United States until I'm an old man, and it won't be from Shiseido or Replicel or Intercytex who came before them, so don't expect me to care. You're stating supposition as if it's fact. You can't know all of these assumptions that you are making are in fact accurate.

A smart business isn't going to waste resources(time,financial, personnel) on something that isn't going to have much long-term demand, even if it's mildly profitable. It's called opportunity cost. They can put their efforts into something else and get more profits than if they keep wasting their time with this.
 

Throwaway94

Experienced Member
My Regimen
I mean there's no evidence that there isn't catch up loss with this. This won't be available in the United States until I'm an old man, and it won't be from Shiseido or Replicel or Intercytex who came before them, so don't expect me to care. You're stating supposition as if it's fact. You can't know all of these assumptions that you are making are in fact accurate.

A smart business isn't going to waste resources(time,financial, personnel) on something that isn't going to have much long-term demand, even if it's mildly profitable. It's called opportunity cost. They can put their efforts into something else and get more profits than if they keep wasting their time with this.

I understand that my suppositions aren't fact but they make much more sense than the alternative. We do know Shiseido is still pursuing this so it's in their best interest not to waste time and resources taking new grafts when all they need to do is freeze it and thaw some twice a year.

HairClone is really just rebranded Intercytex though and they have a decent shot of commercialising in the UK in the next few years. Albeit for extortionately high prices.
 

That Guy

Banned
My Regimen
No your opinion was based on unrealistic expectations. "Omg it didn't turn a NW5 in a NW1, Such a fail bro!"

Mine is based on reality.

"We are very pleased that the data from this randomized, placebo-controlled, double-blinded, dose-ranging clinical study of 65 patients (male and female) with pattern hair loss confirms, with statistical significance, the observations from our ph 1 trial in a larger cohort of patients including females, a wide variety of ages and hair loss, and compared with a placebo-control. In summary, the study produced a statistically significant and clinically meaningful increase in hair density and diameter as measured nine months after treatment,” stated RepliCel’s Chief Medical Officer, Dr. Rolf Hoffman.

Btw, shiseido updated their site in february this year, let's look what they say:

In recent years, technology has evolved remarkably, particularly in the development of digital technology and various devices that are greatly changing our lives. We apply these technological trends using our strengths to offer personalization and e-commerce counseling which allow customers to choose the skincare and makeup items that suit them without going to a store.
We also pursue hair regenerative medicine and create new beauty solutions that support skin health and beauty from the inside through food.

https://corp.shiseido.com/en/rd/development/

Now let's read the conclusions of the actual new study:

https://www.sciencedirect.com/science/article/abs/pii/S0190962220302723

Conclusion
The results suggest that cell therapy with autologous DSC cells may be useful as a new therapeutic method for treating MPHL and FPHL.


"Bu..bu it's not coming out bro, they couldn't regrow a NW5 to NW1! Complete failure bro!"

Strawman. Go through this thread. We have also already been over how RepliCel sucking off investors is not "evidence. You're also forgetting this is in Shiseido's hands; what RepliCel says literally matters not.

I have also never said, nor expected, this to restore any norwoods.

I expect it to do what the initial study showed it could do: Maintain existing hair after one treatment.

The Japanese have failed to reproduce prolonged results as good as phase 1.
 

Pigeon

Senior Member
My Regimen
Strawman. Go through this thread. We have also already been over how RepliCel sucking off investors is not "evidence. You're also forgetting this is in Shiseido's hands; what RepliCel says literally matters not.

I have also never said, nor expected, this to restore any norwoods.

I expect it to do what the initial study showed it could do: Maintain existing hair after one treatment.

The Japanese have failed to reproduce prolonged results as good as phase 1.
9 months of maintenance is good imo, of course everyone wished it would be 2 years or longer but that was not realistic tbh.

So far Shiseido is still in the game and nothing shows they won't commercialize it unlike you were saying.

The real question for us in the west will be that of practicality. Cost, travel, etc. But anyway even if it will be a hassle to get done, this will be the future of hairloss treatment.
 

That Guy

Banned
My Regimen
9 months of maintenance is good imo

Yes...in your opinion.

Objectively, however, 9 months after a biopsy when more-permanent, cheaper, no-biopsy-required options exist is crap. Especially given that they do not have the infrastructure to keep the cells indefinitely and even if they did, the cost of the treatment would then shoot up astronomically.

and despite what you want to believe, no one is going to pay thousands of dollars every nine months out of paranoia of finasteride.

everyone wished it would be 2 years or longer but that was not realistic tbh.

Except it was realistic because phase 1 showed sustained results after FIVE YEARS.

Fuuuck man

So far Shiseido is still in the game and nothing shows they won't commercialize it unlike you were saying

Logic, market history, etc. tells us they won't.

this will be the future of hairloss treatment.

Lol
 

Pigeon

Senior Member
My Regimen
Lol if you really believed this would give 5 years of maintenance. Anyway, we'll see in the future but one thing's for sure we can forget about RCH for a couple of years.
 

topicalthunder

Member
My Regimen
The results give maintenance, yes, but it won’t be commercialised. Not enough of a market for maintenance, be honest to yourself.

Without substantial regrowth they won’t even get the investments needed to make this a reality. Shareholders want big money makers, not obscure maintenance treatments that only a very small fraction of people will be able to even afford and use.
 

Pigeon

Senior Member
My Regimen
The results give maintenance, yes, but it won’t be commercialised. Not enough of a market for maintenance, be honest to yourself.

Without substantial regrowth they won’t even get the investments needed to make this a reality. Shareholders want big money makers, not obscure maintenance treatments that only a very small fraction of people will be able to even afford and use.
Didn't know we had so many business analysts here, lol.

There are still too many unknown variables to draw any conclusions. But untill now, your "analysis" is nothing more than conjecture and RCH is still in development by Shiseido
 

topicalthunder

Member
My Regimen
Didn't know we had so many business analysts here, lol.

There are still too many unknown variables to draw any conclusions. But untill now, your "analysis" is nothing more than conjecture and RCH is still in development by Shiseido

Exactly, at the current time it is not a viable treatment. You said it yourself.
 
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