Puretech Health - Half Year Report - 08/30/2017

H

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İf you live in Europe it doesn't matter if you have to fly to Japan for Tsuji or to the US for Follica, either way you have to fly multiple times. Tsuji twice and Follica maybe every 1-2 years for another session. Both won't come to Europe immediately, so still fuckked up traveling costs.
Let's say its not even available in your state for awhile what then? Traveling is going to add up for multiple wounding sessions and paying monthly or annually for the aftercare products.
 

Omega2327

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First of all, this got way more heated than I intended, and I'm not about to get involved in any drama. I'm just trying to have a civil debate here.

Any treatment that requires a biopsy and wait time on that biopsy is less desireable unless it is literally your only option.

I honestly don't really give two shits about a tiny punch if it gives me a thick head of hair with an excellent looking hairline.... Follica cannot do that. It cannot provide great terminal density and it cannot create a hairline. Period.

You don't think other people, especially in Japan, will hatch the same plan?

I'm sorry, but anyone who would expect to be toward the front of the line just because they're trying to get at it early is naive, there is a significant element of chance here. Sure you can increase your odds, but you talk like it's a surefire thing — it's not.
I'm going to have to disagree. And we may have to agree to disagree on this point because it's a dead end argument. But I'll say my peace: I mean 10,000 is still a decent number of people and yes, I do think if you call at the very earliest possible time, then you have pretty damn good odds of getting your foot in the door. At the very least, this contradicts your point of "almost no one being able to afford it". If barely anyone can afford it, then there won't be much demand at all, so I shouldn't have to worry about slots filling up...right? Pick one.

A cure is anything that relieves you of the symptoms of the disease even if you have to perpetually use some device or meds.

If we're getting into a debate over semantics, then this may be a dead end argument as well. But again I'll say my peace: A cure for me (and probably for most people) is one that could effectively give a bald man a full dense head of hair with a good looking hairline. Follica cannot do this. Tsuji's method can. If that is really your definition of a cure, then you would consider the big 3 to be a cure just because it can all but halt hairloss and even provide improvement? I am not buying that at all, and I think most people would agree.

With Follica, at least by their own reports and science that confirms the basis of their tech, there is also theoretically no reason why you shouldn't be able achieve normal density.

According to 'http://www.keratin.com/aa/aa014.shtml' a normal density is between 200-300 follicles per cm2. Follica will provide not 100...but 25 terminal follicles per cm2 and 75 vellus follicles per cm2. These vellus hair fibers will be thin and wispy so no, I'm not buying this density argument at all.

Lastly, what are you people going to do if Tsuji fails?

Because when it comes to hair cloning, there is literally no one else bringing you that therapy before you're old, bald(er), and your youth is but a distant memory.
I am not only focused on Tsuji, though I can understand how my posts make it seem that way. I absolutely plan on getting Shiseido's treatment hopefully in 2018 if their 'stop loss' potential really pans out. And please don't get me wrong... I think Follica has great potential as a treatment and an additional weapon in the war against hair loss. I am just trying to argue that I don't believe it's comparable to Tsuji.. I am certainly not pissing away my youth. I'm a NW1+ and honestly my hairloss isn't even noticeable to people except for myself. I'm having a f*****g ball in life tbh. However, I am trying to plan for the future and for me, Tsuji is the future (and I'm also very hopeful for Shiseido).

"Tsuji" is a business deal between 3 companies, and the more companies in a business deal, the greater the potential for one not keeping up their end of the deal (Replicel & Shiseido) and dragging everything down for years.

There are a lot of "what ifs" at play. What if their cell culturing technique doesn't work for human cells? What if there is some other technological setback? What if one company pulls out of the deal? What if one lags behind? Etc.

I think this comment about the riskiness of the 3 companies is just ridiculous speculation. It does not hold any real basis at all. If we're resorting to arguments like this then yes, we should also truly be concerned with North Korea's missiles flying over Japan... It's a risk right?

There are what ifs for Follica and for any other company as well... You never truly know until it's out.
 

Christian Miller

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First of all, this got way more heated than I intended, and I'm not about to get involved in any drama. I'm just trying to have a civil debate here.



I honestly don't really give two shits about a tiny punch if it gives me a thick head of hair with an excellent looking hairline.... Follica cannot do that. It cannot provide great terminal density and it cannot create a hairline. Period.


I'm going to have to disagree. And we may have to agree to disagree on this point because it's a dead end argument. But I'll say my peace: I mean 10,000 is still a decent number of people and yes, I do think if you call at the very earliest possible time, then you have pretty damn good odds of getting your foot in the door. At the very least, this contradicts your point of "almost no one being able to afford it". If barely anyone can afford it, then there won't be much demand at all, so I shouldn't have to worry about slots filling up...right? Pick one.



If we're getting into a debate over semantics, then this may be a dead end argument as well. But again I'll say my peace: A cure for me (and probably for most people) is one that could effectively give a bald man a full dense head of hair with a good looking hairline. Follica cannot do this. Tsuji's method can. If that is really your definition of a cure, then you would consider the big 3 to be a cure just because it can all but halt hairloss and even provide improvement? I am not buying that at all, and I think most people would agree.



According to 'http://www.keratin.com/aa/aa014.shtml' a normal density is between 200-300 follicles per cm2. Follica will provide not 100...but 25 terminal follicles per cm2 and 75 vellus follicles per cm2. These vellus hair fibers will be thin and wispy so no, I'm not buying this density argument at all.


I am not only focused on Tsuji, though I can understand how my posts make it seem that way. I absolutely plan on getting Shiseido's treatment hopefully in 2018 if their 'stop loss' potential really pans out. And please don't get me wrong... I think Follica has great potential as a treatment and an additional weapon in the war against hair loss. I am just trying to argue that I don't believe it's comparable to Tsuji.. I am certainly not pissing away my youth. I'm a NW1+ and honestly my hairloss isn't even noticeable to people except for myself. I'm having a f*****g ball in life tbh. However, I am trying to plan for the future and for me, Tsuji is the future (and I'm also very hopeful for Shiseido).



I think this comment about the riskiness of the 3 companies is just ridiculous speculation. It does not hold any real basis at all. If we're resorting to arguments like this then yes, we should also truly be concerned with North Korea's missiles flying over Japan... It's a risk right?

There are what ifs for Follica and for any other company as well... You never truly know until it's out.
Amen!
 

Endmymisery

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First of all, this got way more heated than I intended, and I'm not about to get involved in any drama. I'm just trying to have a civil debate here.



I honestly don't really give two shits about a tiny punch if it gives me a thick head of hair with an excellent looking hairline.... Follica cannot do that. It cannot provide great terminal density and it cannot create a hairline. Period.


I'm going to have to disagree. And we may have to agree to disagree on this point because it's a dead end argument. But I'll say my peace: I mean 10,000 is still a decent number of people and yes, I do think if you call at the very earliest possible time, then you have pretty damn good odds of getting your foot in the door. At the very least, this contradicts your point of "almost no one being able to afford it". If barely anyone can afford it, then there won't be much demand at all, so I shouldn't have to worry about slots filling up...right? Pick one.



If we're getting into a debate over semantics, then this may be a dead end argument as well. But again I'll say my peace: A cure for me (and probably for most people) is one that could effectively give a bald man a full dense head of hair with a good looking hairline. Follica cannot do this. Tsuji's method can. If that is really your definition of a cure, then you would consider the big 3 to be a cure just because it can all but halt hairloss and even provide improvement? I am not buying that at all, and I think most people would agree.



According to 'http://www.keratin.com/aa/aa014.shtml' a normal density is between 200-300 follicles per cm2. Follica will provide not 100...but 25 terminal follicles per cm2 and 75 vellus follicles per cm2. These vellus hair fibers will be thin and wispy so no, I'm not buying this density argument at all.


I am not only focused on Tsuji, though I can understand how my posts make it seem that way. I absolutely plan on getting Shiseido's treatment hopefully in 2018 if their 'stop loss' potential really pans out. And please don't get me wrong... I think Follica has great potential as a treatment and an additional weapon in the war against hair loss. I am just trying to argue that I don't believe it's comparable to Tsuji.. I am certainly not pissing away my youth. I'm a NW1+ and honestly my hairloss isn't even noticeable to people except for myself. I'm having a f*****g ball in life tbh. However, I am trying to plan for the future and for me, Tsuji is the future (and I'm also very hopeful for Shiseido).



I think this comment about the riskiness of the 3 companies is just ridiculous speculation. It does not hold any real basis at all. If we're resorting to arguments like this then yes, we should also truly be concerned with North Korea's missiles flying over Japan... It's a risk right?

There are what ifs for Follica and for any other company as well... You never truly know until it's out.
You on finasteride omega?
 

H

Senior Member
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A cure for me (and probably for most people) is one that could effectively give a bald man a full dense head of hair with a good looking hairline. Follica cannot do this. Tsuji's method can.
I am very glad that you say this. I don't know what Follica will end up being able to do. It may do better then the dhurat study better then 25 cm or whatever been going around I'd be tickled if it could provide normal density like That Guy says he think may be possible and I hope it does I don't have much faith in that outcome but I wish for the best either way. I get the feeling that some members are saying "well it regrows hair you should be happy a little is better then none" but to me that's settling and with hair in my opinion I dont know how you do that your either balding or you have a full head of hair. Noticeable receding, diffuse, bald spots they all suck the same they create the same self consciousness and they all stem from being uncomfortable with the fact that you don't have a normal head of hair. Imagine having all your front teeth knocked out and all you want is that nice normal smile back you go to the dentist he puts you under you wake up look in the mirror and have smile like Sloth the dentist puts his Salvia pipe in the drawer hands you a Baby Ruth and says "hey some is better then none be thankful your teeth smell amazing". Im diffuse and at this point I just can't settle for half density why would anyone? I've already been there and it sucked why would I got back to having a little more hair but still look balding so its either a full cure or I just will stay buzzed and keep my money and time.
 

d3nt3dsh0v3l

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Nope. I'm pretty risk averse when it comes to potential side effects.
Me too, but I'm fking dying over here with regards to my hair. Acne as teenager reporting in. Body hair since kid reporting in. Sick beard reporting in. Retrograde alopecia reporting in. Crown thinning reporting in. Brb 30 years later prostate cancer and bph reporting in.

Wish I could lower my DHT argh.

But muh neurosteroids...
 

nameless

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I feel pretty damn good, actually; a lot better than when I joined here. A few months over a year since starting the big 3, my hair has improved a lot and no side effects, making more money than I think I ever have been, etc.

You're so full of sh*t. I bet you believe your own bullshit.

If you feel so great, and your hair has improved so much, and you make so much money, why do you continue to hang out at a hair loss website pining for cheap Follica?

ROFLMAO
 
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nameless

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You, on the other hand, still seem to be as miserable as ever; flip flopping constantly on whether or not you're going to be cured of both hairloss and old age and destroying 22-year-old vaginas at clubs in the next 3 years, or if it's all for not and you'll wind up dying alone.


Calm down That Guy. Getting mad at me won't save cheap Follica for customers who have no money.

If Follica comes to market at all it will be shortly before Tsuji; or about the same time as Tsuji; or maybe even after Tsuji. My advice to you is for you to get a 2nd job so you might be able to afford Tsuji's treatment when it comes out. Tsuji's treatment will be the real deal. Things aren't looking so good for Follica.
 
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nameless

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Motherfucker, you have no room to criticize anyone on this topic lol.

A few months ago, you're were making threads and screaming at everyone about Tsuji and the "inductivity problem" for like a month straight. I said calm tf down and wait because they say their research has shown them a solution.

Now that Tsuji said in an email that said results are awaiting publication, you're all in again lol

TBH, if they do wind up charging per graft like a transplant, I probably could afford that.

But I'm not going to wait for it, cheaper options that would meet my needs would be available before then, highly likely to wind up on a waiting list, and that's all assuming it works and arrives on time.

Tell me, what are you going to do if it doesn't pan out? Or don't, I don't actually care what happens to you.

Yes I changed my opinion about Tsuji when Tsuji gave us new positive information. They said they found a solution to their main technical problem so I upgraded them. We should adjust our opinions as researchers/companies release new information.

Back then when you were saying that Tsuji had solved their technical problems Tsuji was saying they still had to solve their major technical problem. Their technical problem wasn't solved yet but you were saying it was solved. You were bullshitting as usual. Later on Tsuji said they finally solved that problem and I accepted that.

Sadly for you people in the cheap seats, Tsuji's treatment won't be as simple as a hair transplant and it won't be as cheap. I figure Tsuji will cost about $40,000 for a full head of hair. And then there's the cost of airfare to Asia, hotel, restraunt food, transportation while you're in Asia, etc.

I think you should get a 2nd job to supplement your income so you have a chance to scrape together enough money to get Tsuji's treatment when it comes to market in Asia. The holiday season is approaching so the retail stores will be hiring seasonal help soon.

Follica may never come out and even if it does come out it may not be any sooner than Tsuji's treatment. And Follica won't be as good as Tsuji's treatment anyway. I figure you will need $50,000 in cash or credit to cover all of your costs for Tsuji.
 
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Noisette

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Calm down That Guy. Getting mad at me won't save cheap Follica for customers who have no money.

If Follica comes to market at all it will be shortly before Tsuji; or about the same time as Tsuji; or maybe even after Tsuji. .

.
Follica may never come out and even if it does come out it may not be any sooner than Tsuji's treatment. And Follica won't be as good as Tsuji's treatment anyway. I figure you will need $50,000 in cash or credit to cover all of your costs for Tsuji.

Hi Nameless
I don't understand why you are thinking that Follica will be on the market just before or after Tsuji ? For me, it does not make sense.
Doctor Tsuji said that the Human clinical study will begin in March 2019. PMDA (Japan's FDA) could give a conditional limited approval after their trial, so 2020/2021.

Follica would be on the market 1 or 2 years before Tsuji's treatment.

It seems that They've already done a Pivotal Trial of the In-market device (Pivotal trial = phase 3). Because They are expected to receive their data this year.

They have delayed one Pivotal Trial wich is the Pivotal Trial of the In-office device. This Trial will begin after the pilot optimisation (this pilot optimisation is needed in order to improve the phase 3).

They delayed the last Pivotal trial, it could begin at the 1H of 2018. The other studies are not delayed. Follica could be on the market at the end of 2018, beginning of 2019.

I hope that @hellouser will have some news at the World Congress for Hair Research.

David Steinberg, co funder and Director of Follica, is a speaker , a conference at Boston this October.
Maybe a member could be over there and have an interview ?? @Roberto_72 @Admin



Follica.jpg
 

nameless

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Slight correction; Tsuji's team has their sights set on 2020, not 2018. Difference of 2 years, but still worth pointing out.

Another aspect that people forget is that, and this is the only "marketing noise" they've really made, is the announcement of their partnership with the electronics company, Kyocera.

"Tsuji" is a business deal between 3 companies, and the more companies in a business deal, the greater the potential for one not keeping up their end of the deal (Replicel & Shiseido) and dragging everything down for years.

There are a lot of "what ifs" at play. What if their cell culturing technique doesn't work for human cells? What if there is some other technological setback? What if one company pulls out of the deal? What if one lags behind? Etc.

and these kinds of problems happen literally every day and this deal is far from immune to it.

It seems to me like you're reaching for reasons why Tsuji might be disappointing. Your reasons seem like a stretch.

As a matter of fact, I think that since there are 3 companies involved the greater likelihood is that one of these companies might come up with an idea to bring the treatment to more than 10,000 people in the first year. These companies are about one thing - MONEY - and they want to make as much money as possible. And if even just one of these 3 companies perceives a possibility to offer the treatment to more patients the first year then all 3 companies might get into a discussion about it. And then who knows what would come out of those discussions? I understand that for some time now their plan has been for there to be 10,000 customers the first year but plans can change.
 

Christian Miller

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no, it's a brilliant strategy =) Nameless was so desparate all these years to be known as THE clown in all hairloss forums, so he came up with a great plan to push his credibility. it's actually only 20 bucks a year to pay an Indian guy sitting in a click-center and give a supportive LIKE here and there, or even a random post to look like a real intelligent person.
i even spotted a second paid fake friend of Nameless. it's the user cocona.
there are more to come... 20 bucks a year is nothing for an american guy. soon Nameless will have an armada of fake friends, totally ruling the forum =)
LOL
 

nameless

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Hi Nameless
I don't understand why you are thinking that Follica will be on the market just before or after Tsuji ? For me, it does not make sense.
Doctor Tsuji said that the Human clinical study will begin in March 2019. PMDA (Japan's FDA) could give a conditional limited approval after their trial, so 2020/2021.

Follica would be on the market 1 or 2 years before Tsuji's treatment.

It seems that They've already done a Pivotal Trial of the In-market device (Pivotal trial = phase 3). Because They are expected to receive their data this year.

They have delayed one Pivotal Trial wich is the Pivotal Trial of the In-office device. This Trial will begin after the pilot optimisation (this pilot optimisation is needed in order to improve the phase 3).

They delayed the last Pivotal trial, it could begin at the 1H of 2018. The other studies are not delayed. Follica could be on the market at the end of 2018, beginning of 2019.

I hope that @hellouser will have some news at the World Congress for Hair Research.

David Steinberg, co funder and Director of Follica, is a speaker , a conference at Boston this October.
Maybe a member could be over there and have an interview ?? @Roberto_72 @Admin



View attachment 62623

I read a recent quote by Follica wherein they said their pivotal study won't even start until sometime in 2018. I think they said it will start in March 2018 or May 2018. Pivot studies are at least 6 months and then you have to add on more time to organize the results and submit that info to the FDA. Yes, I know that while studies are ongoing companies are organizing their data/resuts but there is still significant work to do after studies end. And again, there could still be further delay(s) for Follica. Don't overlook that Follica has a deserved reputation for delays. The only company I've seen delay as bad as Follica is Histogen. And even without anymore delays I figure that the soonest Follica could turn all of their pivotal study info over to the FDA would be 4th quarter 2018. I get this by assuming that the study begins on time (however unlikely) in March 2018 and it ends in September 2018. Then it will take 1 - 3 months to organize everything for FDA submission and submit everything to the FDA. Based on this I figure submission to FDA will happen between October 2018 and December 2018, and approval will come about 6 -12 months later. Hence, approval would come between June 2019 and December 2019. Given the potential for serious scalp burns from the laser along with the increased absorption of minoxidil and other topical chemicals I think that the FDA is going to go through Follica's information very stringently. So I'm anticipating FDA approval will be closer to December 2019 than to June 2019. And that's if there are no more delays. And given Follica's history of delays, the greater likeihood is that there will be another delay or two. I honestly think we should count on more delays from Follica.

The Tsuji team seems more professional, intelligent, and dependable than the Follica team. Plus, the approval process seems better for Tsuji's treatment. Japan appears to be chomping at the bit to give these cell-based treatments early approval. It seems like Japanese officials have seen enough early studies (involving cell based treatments) to last a lifetime. In Japan, when it comes to cell based therapies, phase 1 studies are the new phase 3 studies. Plus, Japan is surely aware of the potential for medical tourism if they can get a breakthrough baldness treatment to market quickly. Plus there are a lot of people in Japan waiting for a breakthrough hair loss treatment. Plus in Japan it's socially accepted for men to want hair so men's hair loss is considered more serious in Japan than it is in America. I anticipate that once Tsuji's treatment is submitted (to the Japanese regulatory agency) for early marketing it will be approved rapidly.

I read somewhere that when companies are seeking early approval (in Japan) for their cell-based treatments they turn their data/results over to the regulatory agency all throughout the trial process and then the treatment is either given early approval or denied early approval rapidly shortly after the trial ends.

I expect Tsuji to hit the market in Asia in 2020.
 
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nameless

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no, it's a brilliant strategy =) Nameless was so desparate all these years to be known as THE clown in all hairloss forums, so he came up with a great plan to push his credibility. it's actually only 20 bucks a year to pay an Indian guy sitting in a click-center and give a supportive LIKE here and there, or even a random post to look like a real intelligent person.
i even spotted a second paid fake friend of Nameless. it's the user cocona.
there are more to come... 20 bucks a year is nothing for an american guy. soon Nameless will have an armada of fake friends, totally ruling the forum =)

And by the same token how do we know that these morons who like your insane idiotic posts aren't paid by YOU? I mean after all you're the one who knows all about finding people who will like your posts in exchange for a fee. I was not even aware there were people who would do that until you told us about it. But you know all about this practice so maybe you're the one who's hired one of these paid post likers.
 
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nameless

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actually, now that you exposed me, it doesn't make a difference anymore if i tell you the truth anyway: i'm the owner of such a click-center. it's located in mumbay, named "social-loser-support-24/7". we support all sorts of poor guys, whether it's on forums, facebook, instagram, or we can even give you fake calls from hot girls from time to time to impress your friends. (you have to be cool with an Indian accent though).

actually, the writing styles of cocona and christian miller seemed very familiar to me from the very beginning. we once had some employees in our team who went rogue and turned to the competitor team, the team of the brothers salim and arash. i hate those two guys. i believe cocona and christian could be the ones who left my team, the ones Nameless hired as a support.

cocona and christian: tell salim he can suck d.ck


This post is insane.
 
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Trichosan

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...I expect Tsuji to hit the market in Asia in 2020.

I think I read somewhere that when companies are seeking early approval (in Japan) for their cell-based treatments they turn their data/results over to the regulatory agency all throughout the trial process and then the treatment is either given early approval or denied early approval rapidly shortly after the trial ends.

That would be fantastic. Other technologies will have advanced significantly by then also. I'll get my hair restored and pick up a female sexbot.
 

Christian Miller

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actually, now that you exposed me, it doesn't make a difference anymore if i tell you the truth anyway: i'm the owner of such a click-center. it's located in mumbay, named "social-loser-support-24/7". we support all sorts of poor guys, whether it's on forums, facebook, instagram, or we can even give you fake calls from hot girls from time to time to impress your friends. (you have to be cool with an Indian accent though).

actually, the writing styles of cocona and christian miller seemed very familiar to me from the very beginning. we once had some employees in our team who went rogue and turned to the competitor team, the team of the brothers salim and arash. i hate those two guys. i believe cocona and christian could be the ones who left my team, the ones Nameless hired as a support.

cocona and christian: tell salim he can suck d.ck
This one was flat.
Didn't enjoy it much.
Try harder next time.
 
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