Ted Buckland
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Proof That Dht Is Only The Secondary Factor In male pattern baldness
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optimus prime
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Yea, but where are you going with this?
I believe there are androgen-independent pahways in the pathophysiology of pattern baldness. But i think it constitutes a very small portion of the condition. It is an androgen dependent condition which may be influenced by environmental factors and androgen-independent pathways but this does not change the fact that androgens(DHT) are the major driving factor in this condition.
You hypothesize there would be bald eunuchs if there were more of them. Even if this was a fact, this doesn't disprove the good old theory that the presence of androgens are necessary for the condition. As i have said it before, there may be other pathways but their significance is, i believe, low.
Female pattern baldness has the same histopathological features as male pattern baldness. Although it is etiopathogenesis is thought to be more complicated than male pattern baldness, i believe this further shows the presense of androgen independent pathways in Androgenetic Alopecia. There is a case report of a woman who has complete androgen insensitivity syndrome with female pattern baldness.
https://www.ncbi.nlm.nih.gov/pubmed/20128792
I believe AR/Androgen angle is the single major driver of severe baldness. This is the reason why females don't go slick bald, except for very old severe cases.
You hypothesize there would be bald eunuchs if there were more of them. Even if this was a fact, this doesn't disprove the good old theory that the presence of androgens are necessary for the condition. As i have said it before, there may be other pathways but their significance is, i believe, low.
Female pattern baldness has the same histopathological features as male pattern baldness. Although it is etiopathogenesis is thought to be more complicated than male pattern baldness, i believe this further shows the presense of androgen independent pathways in Androgenetic Alopecia. There is a case report of a woman who has complete androgen insensitivity syndrome with female pattern baldness.
https://www.ncbi.nlm.nih.gov/pubmed/20128792
I believe AR/Androgen angle is the single major driver of severe baldness. This is the reason why females don't go slick bald, except for very old severe cases.
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H
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Ya I get that but we get a "male pattern baldness its totally not what you think it is dht must have an accomplice hidden in the shadows!!" thread weekly so everyone knows there may be something else going on but you gotta give us something else man tell us who dht's working with and I will slay him/her where they stand!
I did not deny the fact that androgen independent pathways may be more prominent in some cases as shown in the study of occurence of Androgenetic Alopecia in pediatric population. If you assert that non-androgenic pathways are the driving force, you have to present the evidence for it. The pediatric Androgenetic Alopecia study and pattern baldness in AIS only proves that there may be pathways other than androgen dependent ones. How do you come to the conclusion that the androgen independent pathways is the major driving factor?
Also, you forget the role of adrenarche in pediatric Androgenetic Alopecia. Adrenarche starts before puberty around age 10, some children start to have oily face, acne, body odor. DHEA-S increases in adrenarche and it is a source for DHT in peripheral tissues.This is from that pediatric Androgenetic Alopecia study:
H
Senior Member
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Why do jak inhibitors regrow horseshoe hair patterns?
I understand your point but where is your evidence that proves we are more vulnerable than non-balding men other than an immunodeficient mice model?
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Nonbalding men don't necessarily have low DHT levels, but they don't have the reaction to male hormones like we do, the downstream effects like PGD2, TGFb, and negative growth factors. Removing Dht doesn't turn off the "Switches" that it left on.
There's also cases of thinning from things like high prolactin levels, iron deficiency, even wearing cornrolls or ponytails too tightly.
There's also cases of thinning from things like high prolactin levels, iron deficiency, even wearing cornrolls or ponytails too tightly.
I didn't mean the vulnerability of follicles against DHT. I meant the immune dysfunction part you insist balding people have. Balding men are particularly sensitive to DHT, obviously. What i am asking is how you come to the conclusion that the problem is immune dysfunction?
Androgens influence macrophages through AR and supress wound healing. Elderly men have slower wound healing compared to elderly women. This is specifically mediated by DHT through AR. Androgen stimulation of macrophages causes inflammation and it is implicated in prostatic hyperplasia. I believe, this must have implication in Androgenetic Alopecia as well.
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I don't think he's the only one. What surprised me yesterday was seeing that Follica has their male pattern baldness treatment under the "Immune System" section in their official website.
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Probably. Not necessarily.
Like the last couple posts above mention, immune factors and their actual impact are extremely difficult to examine due to many complex pathways and cell signaling regulators. I'm astounded everyday because I see people of all ages whose immune system is utter sh*t, yet their hair is so thick and dense it makes mine look like a Chenobyl survivor.