It's complicated to try to answer that, but I think we can come to a general idea of the risk level.
RU58841 metabolism is well described
here.
The main point is 1% of RU58841 is metabolized into a systemic antiandrogen (cyanonilutamide). This is probably somewhere on par in potency with similar compounds like nilutamide or flutamide.
If you look at high dose oral antiandrogens like nilutamide, or flutamide, or bicalutamide, you will find they generally list cardiac effects as: "(1% to 10%): Hypertension, angina, heart failure" (
ref).
This is a dose-related effect that likely has to do with systemic androgen deprivation in massive doses blocking androgens from binding to the heart muscle, and thus leading to atrophy or dysfunction, the same way systemic androgen deprivation causes muscle wasting.
However in tiny systemic doses, most antiandrogens hopefully shouldn't have this effect. For example, I use the most RU of anyone I know at 300 mg a day. If all this all immediately absorbs into my blood, I will have a pretty powerful systemic androgen blockade for an hour or two (as RU is roughly as strong as flutamide), after which the majority of RU will be broken down into inert byproducts. 1% overall will make cyanonilutamide, or around 3 mg a day.
By contrast, nilutamide for prostate cancer is dosed at 150-300 mg a day, so I'm getting at most 2% of the effective systemic castration dose long term. And that's if it all goes systemic (most will probably stay on or in my scalp).
The point is, it's not a black and white science, but I think the odds of anyone developing heart failure from RU58841 is pretty low. You'd have to be susceptible to it.
I've been meaning to get an ECG done, as I've been feeling dizzy post exercise the past few years, which isn't technically anything new for me. But I feel like I should go check it out. So quite sincerely, if I do and I'm already dying, I'll definitely let you guys know.
(srs)
