Pictures!!!!!!!!!! of proanthocyandin results on mice

BH 90 NWtwo 10

Established Member
Reaction score
1
wow i better reup on my apple poly

does that mean it works as well as minoxidil 1%?? wat bout 2 and 5?
 

michael barry

Senior Member
Reaction score
14
They used one percent proanthocyanidin solution and one percent minoxidil. It would be interesteing to see what would happen if they upped the proanthocyandin dosage to say, three percent along with the minoxidil dosage.


Barley and apple proanthos seem to stop the action of TGF-beta 1.

Apples seem to stop Protien Kinease C also.

Barley seems to stop TGF-beta 2 also.


Grape seed extract seems to stop Protien Kinease C.



All of the above substances are anti-gens released by the dermal papilla in response to DHT uptake at the follicle. They are "growth" suppressors. TGF beta 1 and 2 are thought to be the "most important" in hair. There are some others that have been found (thrombospondin, Dppk, FGF 5, IL-1). Silica is thought to inhbit IL-1 expression.


Internal proanthos have not really been validated for hair growth. We have only seen them tested topically. Im kind of doubtful about them because alot of beer drinkers would seemingly have pretty darn good hair if that were the case due to the high barley content in beer.


However............................when you consider some of the "old" remedies for baldness like apple cider vinegar, beer and eggs shampoo (or slow boiling beer until it loses a third of its volume and then using it as a rinse), and "cucumber" or "onion" juice (lots of silica in those), you begin to think some cheap additions to one's regimine might bear fruit. TGF-beta 1 and 2 are probably the most important negative growth factors to be counteracted in baldness. Finasteride reduces tgf-beta expression by some 30 percent in the scalp, so Im hoping that adding something like barley extract topically could lower that some more.
 

hedgehog_info

Member
Reaction score
0
What are the results?

We have already performed toxicologic studies (Takahashi et al. 1999) and a human pilot clinical study using procyanidin B-2, and confirmed that it is safe enough for topical use of procyanidin B-2 and effectiveness in curing androgenetic alopecia.3 We are now improving the industrial process for manufacturing procyanidin oligomers, and are planning a large-scale human clinical test.

The article is from 1998????
 

mumuka

Established Member
Reaction score
0
hedgehog_info said:
What are the results?

We are now improving the industrial process for manufacturing procyanidin oligomers, and are planning a large-scale human clinical test.[/b]

The article is from 1998????


I guess something went wrong in those 9 years thats why we never hears about any large scale human tests and maybe thats why nobody else is doing any testing with them except the Kamimura Takahashi team.I could be wrong though...
 

michael barry

Senior Member
Reaction score
14
Hedgehog,

Im glad that YOU in particular seen the results. I have actually seen BETTER pictures of more impressive results of hair growth on shaved mice at skinbio.com as a result of copper peptides. This is why I didn't go crazy over the pictures you posted on mice.


There is a picture of apple proanthocyandin success on a man. Here it is,
http://www.applepoly.com/procyanidin-b-2/enlarge_2.htm


That is pretty impressive. However, the reason one might get excited over the proanthocyandin results are two fold. One is the fact that we can probably extract these fairly easily at home (they were just culled from commercial grade apple juice, barley <ton of barley in beer>, and grape seed oil. But the second reason that its sort of exciting is that it represents a sub-dermal papilla way of counteracting hairloss, with no anti-androgenic methods used at all.

The dermal papilla released growth inhibitors are TGF-beta 1
TGF-beta 2, Protien Kinease C, IL-1, FGF-5, Dppk, Throbospondin. We think that we can suppress the first four of those with barley proanthocyandins, grape seed proanthocyandins, and silica. We dont know about the other three, and of course there are some dermal papilla growth inhibitors IN HUMAN BEINGS, (mice and humans dont have the exact same papilla inhibitors it seems) that have not been discovered yet.



This is why HUMAN testing is so damned much more important than testing on SHAVEN mice. Getting hair to grow quicker is something that MSM and abscorbyl palmitate will do. But it doesn't really counteract pattern baldness.



Im dissapointed that applepoly hasn't put up more pictures of results however. I dont know why these companies think one damned photo is going to convince everyone of the efficacy of their product. Ten good pictures would be much more like it, dated and time stamped would be better.


On why "hasnt anything happened" with the proanthocyandins.................things have happened. Apple poly sells them, they are in Revita shampoo, and Spectral DNC, they are in a Japanese shampoo for hairloss, apple fruit extract is in some L'Oreal Shampoos, etc.

SOD's put in Prox-N, according to Dr. Peter Proctor, are there to suppress TGF-beta, although he didn't say if one got 100% inhibition with it or not.



Hedgehog, I know you aren't excited about cloning, but I am. I truly think male pattern baldness is something men will have to fight inscessantly until we can find a way to just multiply the donor area and use that hair for a guy's head. Then, even relatively weak anti-androgens like usage of Nizoral should be able to keep hair on one's head. Other than some genetic therapy topically applied that literally changes genes in some newfangled way, I think treatments of any kind are simply keeping nature from taking its course up there. That being said, I have hair up there, and pretty good hair............because Ive used stuff over the years. It would hit the floor in a couple of winters if I stopped everything.
 

hair today gone tomorrow

Senior Member
Reaction score
1
the paul mitchell conditioner i use has grape seed extract in it as well as carrot extract i believe...obv. this isnt a topical and I dont know the concentration of the grape seed extract...but at least its in there :lol:
 

michael barry

Senior Member
Reaction score
14
paul mitchel tea tree oil shampoo has black tea in it, which supposedly has a suppressive effect on tgf beta.

I dont think thats in there for no reason at all
 

hedgehog_info

Member
Reaction score
0
Hedgehog, I know you aren't excited about cloning, but I am. I truly think male pattern baldness is something men will have to fight inscessantly until we can find a way to just multiply the donor area and use that hair for a guy's head. Then, even relatively weak anti-androgens like usage of Nizoral should be able to keep hair on one's head. Other than some genetic therapy topically applied that literally changes genes in some newfangled way, I think treatments of any kind are simply keeping nature from taking its course up there. That being said, I have hair up there, and pretty good hair............because Ive used stuff over the years. It would hit the floor in a couple of winters if I stopped everything.

Well honestly HM is probably easier to get past the FDA. Most of the process occurs in vitro. Maybe when I am rich I can afford to do some experiments. Until then....
 

abcdefg

Senior Member
Reaction score
782
mice are not people. I dont think mice have inflammation like people do which we always ignore because we cant figure that out.
 
Top