Phase 2 for GT20029 begins in China

[Ralph Wiggum]

How soon until this stuff is available on the grey market in the US?

Kintor Pharmaceutical Starts Phase 3 Trials | Hair Loss Cure 2020

Kintor Pharmaceutical was founded in China. Kintor's pyrilutamide AR antagonist will treat hair loss (androgenic alopecia). Phase 3 trials begin in early 2022.

www.hairlosscure2020.com

Phase 2 for GT20029 (AR degrader) Begins in China

Kintor Pharma just completed the first patient enrollment in China for its proteolysis targeting chimera (PROTAC) compound GT20029. The Phase II clinical trial is a multi-center, randomized, double-blind, placebo-controlled study. It will evaluate the efficacy and safety of androgen receptor degrader GT20029 for treating male pattern baldness in Chinese adults. Kintor plans to enroll a total of 180 male Androgenetic Alopecia patients from 12 centers nationwide.

 

[Kagaho]

While its good news this drug is far from being available worldwide, like 3-5 years at least.

Im a bit worried about Kintor, their stock have been falling steadily for the last few months. Most likely because they spent millions on multiple clinical trials for drugs like Proxalutamide for COVID which apparently didnt worked as expected.

While its true they have raised a good amount ($100 million) through 2 top-up share placements last december they are running both FDA and China regulatory clinicial trials which means they will be burning cash at light speed.

So, they will really need pyrilutamide to not only succeed phase 3 trials but also to become a blockbuster drug ASAP

 

[Kagaho]

How soon until this stuff is available on the grey market in the US?

Kintor Pharmaceutical Starts Phase 3 Trials | Hair Loss Cure 2020

Kintor Pharmaceutical was founded in China. Kintor's pyrilutamide AR antagonist will treat hair loss (androgenic alopecia). Phase 3 trials begin in early 2022.

www.hairlosscure2020.com

Phase 2 for GT20029 (AR degrader) Begins in China

Kintor Pharma just completed the first patient enrollment in China for its proteolysis targeting chimera (PROTAC) compound GT20029. The Phase II clinical trial is a multi-center, randomized, double-blind, placebo-controlled study. It will evaluate the efficacy and safety of androgen receptor degrader GT20029 for treating male pattern baldness in Chinese adults. Kintor plans to enroll a total of 180 male Androgenetic Alopecia patients from 12 centers nationwide.

Its a very complex molecule, way more difficult to synthesize than common ar bockers.

So if they succeed it wont be cheap

 

[Ralph Wiggum]

Its a very complex molecule, way more difficult to synthesize than common ar bockers.

So if they succeed it wont be cheap

Any thoughts on how much it would cost per month?

 

[Gonalgique]

What to expect from GT0029 ? hair regrow or hair maintenance ?

 

[Modill]

If there isn’t a clear explanation about why it won’t go systemic to the body blood, it could be the most dangerous hairloss drug ever.

Think about a drug degrading the AR from all your body.

 

[Ralph Wiggum]

If there isn’t a clear explanation about why it won’t go systemic to the body blood, it could be the most dangerous hairloss drug ever.

Think about a drug degrading the AR from all your body.

They should figure out a way to do some kind of safety test before they make this available. I'm going to call my scientist friends to see if they've thought of that!

 

[whymedamn]

If there isn’t a clear explanation about why it won’t go systemic to the body blood, it could be the most dangerous hairloss drug ever.

Think about a drug degrading the AR from all your body.

exactly. the effect could be like the poison pill finasteride .. but more permanent as it degrades receptors ..

 

[coolio]

Androgen receptors are perpetually being replaced in the body. Degrading the existing ones would be a temporary effect.

 

[Kagaho]

Androgen receptors are perpetually being replaced in the body. Degrading the existing ones would be a temporary effect.

It takes a few days to regenerate though. If this stuff is potent enough and safe it can be the perfect replacement to ARIs like finasteride/dutasteride and AR blockers of course

 

[Modill]

Androgen receptors are perpetually being replaced in the body. Degrading the existing ones would be a temporary effect.

How can you know that? Is there any other similar drug on the market?

 

[Janks16]

Nobody knows.

 

[coolio]

How can you know that?

It's accepted mainstream science. We are not the first people to ever study receptors.

 

[Modill]

It's accepted mainstream science. We are not the first people to ever study receptors.

You try first then. I wouldn’t try this even approved by FDA. I don’t believe in FDA

 

[coolio]

You try first then. I wouldn’t try this even approved by FDA. I don’t believe in FDA

Yep, there is a big conspiracy to make you try this product. Every person on earth who understands how androgen receptors work is in on it.

 

[whymedamn]

Well FDA approved finasteride. And that turned out to change man into lesbians, ..

 

[Baldingtooyoung]

Well FDA approved finasteride. And that turned out to change man into lesbians, ..

You're acting like a b**ch and aren't using finasteride, while 90% of us uses finasteride or dutasteride without a problem.
So please stfu and keep this thread clean of your anti (or pro, I don't care) finasteride content.

 

[coolio]

while 90% of us uses finasteride or dutasteride without a problem

Define "without a problem."

A drug with no side effect problem has zero sides. None. Nada. Zip. You could switch the user's supply with fake placebos and they wouldn't know the difference until their hair started falling out several weeks later. If you think this is how it goes for 90% of 5ar drug users then I have a bridge for sale.

 

[Baldingtooyoung]

Define "without a problem."

A drug with no side effect problem has zero sides. None. Nada. Zip. You could switch the user's supply with fake placebos and they wouldn't know the difference until their hair started falling out several weeks later. If you think this is how it goes for 90% of 5ar drug users then I have a bridge for sale.

Ok bro, go make a thread about it instead of having the f*****g same conversation for 10 years in every new drug thread.
Let's keep this clear of that talk.

 

[Modill]

90% finasteride users with no problem, except flaccid penis, arrhythmias, insomnia, depression. Finasteride for men is like the contraceptive pill for women, pure poison that changes even your way of being and seeing life.