Clinical diagnosis of alopecia areata, alopecia totalis, or alopecia universalis
Patients must be ≥ 18 years of age to participate.
All patients must signed informed consent.
Must have at least two distinct alopecia areata patches >1.0 cm in diameter located on the right and left sides of the scalp. Patient must agree to treat only one side of the scalp with drug, to have photos taken, and to return for follow-up visits
Women of childbearing potential must use two acceptable methods of contraception to prevent pregnancy and agree to do so for one month after their last application of Targretin® gel
Men with sexual partners who are of childbearing potential or pregnant must use condoms during sexual intercourse during Targretin® gel therapy and for one month after the last applicationP
Patients will be asked to voluntarily contribute pre- and post biopsies for research studies (3 mm punch biopsies for H & E and immunohistochemistry of T-cells). However, failure to consent to biopsies will not exclude them from the study.
Exclusion: