Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

[waynakyo]

Androgenetic alopecia (Androgenetic Alopecia) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating Androgenetic Alopecia. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, Androgenetic Alopecia treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of Androgenetic Alopecia certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating Androgenetic Alopecia via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and Androgenetic Alopecia therapy.

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy - PubMed

Androgenetic alopecia (Androgenetic Alopecia) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need...

pubmed.ncbi.nlm.nih.gov