- Reaction score
- 528
ORM-15341 is the main active metabolite of Daro. While Daro has a 15.8hr half life, it converts to
ORM-15341 which has an additional 10hr half life. So in effect all of the drug which goes systemic will have a half life of nearly 26 hours which is not optimal.
However, ORM-15341 is just as strong as Daro
(Ki) of 8 nM and an IC50 of 38 nM for ORM-15341
(Ki) of 11 nM and an IC50 of 26 nM for Daro
For anyone using Darolutamde topically is would be more advantageous to switch to its metabolite. This would allow you to avoid systemic side effects to a higher extent while still receiving all of the topical benefits.
What was surprising to me was Gang Lou (the guy who supplies Daro) has this in stock as well. My theory is that @IdealForehead must have figured this out and asked Gang if he would be able to supply the metabolite to him instead. They are the same price from Gang so if anyone is looking to try Daro I recommend using this instead
Also heres a little cost calculation
At 2m Bicalutamide per day I got side effects but it was super effective for hairloss. Given this is around 16x stronger on a milligram basic 2mg is a very high dose, but I will use it to be conservative.
500mg costs $150USD
at 2mg/day 500mg last 250 days
$0.60 per day
Now some people were complaining that they didn't notice anything on Darolutamdie but that is because most people used the completely wrong vehicle. You need to have a lipophillic vehicle that will be able to get the drug to the hair follicle. I have had great results with K&B solutions for bicalutamide/finasteride/spirinolactone. I much recommend it over propylene glycol, for one its better, but 2 its much healthier for your scalp.
ORM-15341 which has an additional 10hr half life. So in effect all of the drug which goes systemic will have a half life of nearly 26 hours which is not optimal.
However, ORM-15341 is just as strong as Daro
(Ki) of 8 nM and an IC50 of 38 nM for ORM-15341
(Ki) of 11 nM and an IC50 of 26 nM for Daro
For anyone using Darolutamde topically is would be more advantageous to switch to its metabolite. This would allow you to avoid systemic side effects to a higher extent while still receiving all of the topical benefits.
What was surprising to me was Gang Lou (the guy who supplies Daro) has this in stock as well. My theory is that @IdealForehead must have figured this out and asked Gang if he would be able to supply the metabolite to him instead. They are the same price from Gang so if anyone is looking to try Daro I recommend using this instead
Also heres a little cost calculation
At 2m Bicalutamide per day I got side effects but it was super effective for hairloss. Given this is around 16x stronger on a milligram basic 2mg is a very high dose, but I will use it to be conservative.
500mg costs $150USD
at 2mg/day 500mg last 250 days
$0.60 per day
Now some people were complaining that they didn't notice anything on Darolutamdie but that is because most people used the completely wrong vehicle. You need to have a lipophillic vehicle that will be able to get the drug to the hair follicle. I have had great results with K&B solutions for bicalutamide/finasteride/spirinolactone. I much recommend it over propylene glycol, for one its better, but 2 its much healthier for your scalp.
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