ONION TOPICAL

[saintsfan92344]

I have been doing it once or twice a week, not sure its doing anything for hair loss but it doesn't hurt anything for sure, there are some people that are having regrowth or should I say having increased hair growth, although not sure its from male pattern baldness but hey onions are cheap and sulphur is an important nutrient in your hair. waynakyo what are you are you seeing on OC, I have just heard about it to be honest

 

[squeegee]

[h=1]Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress.[/h]Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, Zhu YZ.
[h=3]Source[/h]Department of Pharmacology, School of Medicine, National University of Singapore, Singapore, Singapore.

[h=3]Abstract[/h][h=4]BACKGROUND:[/h]Hydrogen sulfide (H₂S) has been shown to have cytoprotective effects in models of hypertension, ischemia/reperfusion and Alzheimer's disease. However, little is known about its effects or mechanisms of action in atherosclerosis. Therefore, in the current study we evaluated the pharmacological effects of H₂S on antioxidant defenses and mitochondria protection against hydrogen peroxide (H₂O₂) induced endothelial cells damage.
[h=4]METHODOLOGY AND PRINCIPAL FINDINGS:[/h]H₂S, at non-cytotoxic levels, exerts a concentration dependent protective effect in human umbilical vein endothelial cells (HUVECs) exposed to H₂O₂. Analysis of ATP synthesis, mitochondrial membrane potential (ΔΨm) and cytochrome c release from mitochondria indicated that mitochondrial function was preserved by pretreatment with H₂S. In contrast, in H₂O₂ exposed endothelial cells mitochondria appeared swollen or ruptured. In additional experiments, H₂S was also found to preserve the activities and protein expressions levels of the antioxidants enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in H₂O₂ exposed cells. ROS and lipid peroxidation, as assessed by measuring H₂DCFDA, dihydroethidium (DHE), diphenyl-l-pyrenylphosphine (DPPP) and malonaldehyde (MDA) levels, were also inhibited by H₂S treatment. Interestingly, in the current model, D, L-propargylglycine (PAG), a selective inhibitor of cystathionine γ-lyase (CSE), abolished the protective effects of H₂S donors.
[h=4]INNOVATION:[/h]This study is the first to show that H₂S can inhibit H₂O₂ mediated mitochondrial dysfunction in human endothelial cells by preserving antioxidant defences.
[h=4]SIGNIFICANCE:[/h]H₂S may protect against atherosclerosis by preventing H₂O₂ induced injury to endothelial cells. These effects appear to be mediated via the preservation of mitochondrial function and by reducing the deleterious effects of oxidative stress.

 

[swingline747]

Just ordered a derma roller. Read to NOT use NOZ or minoxidil after rolling since it may enter the blood stream. BUT I was actually debating on making a garlic/onion juice mix with my juicer/nutribullet and putting that on my head the days I roll. Think this is feasible or a bad idea?

 

[saintsfan92344]

I have an electric onion chopper, just chop it fine. Put it in a mesh strainer and push down on the chopped onion, i found it pretty amazing how much juice u can get out of 1/4 onion

 

[squeegee]

I don't think that you need onion juice to get the same results.. Sublimed Sulphur contain the same stuff. It is pure yellow sulphur..

http://www.amazon.com/Humco-sulfur-sublimed-powder-USP/dp/B000GCOLM0

Females on their hair growth forums swear by it..

 

[swingline747]

I don't think that you need onion juice to get the same results.. Sublimed Sulphur contain the same stuff. It is pure yellow sulphur..

http://www.amazon.com/Humco-sulfur-sublimed-powder-USP/dp/B000GCOLM0

Females on their hair growth forums swear by it..

mix it in water?

 

[squeegee]

mix it in water?

It is oil soluble. Minoxidil will be a proper vehicle for it.

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Garlic Boosts Hydrogen Sulfide To Relax Arteries

http://www.sciencedaily.com/releases/2007/10/071016131534.htm
Eating garlic is one of the best ways to lower high blood pressure and protect yourself from cardiovascular disease. A new study from the University of Alabama at Birmingham (UAB) shows this protective effect is closely linked to how much hydrogen sulfide (H[SUB]2[/SUB]S) is produced from garlic compounds interacting with red blood cells.

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The UAB researchers found this interaction triggered red blood cells to release H[SUB]2[/SUB]S, which then led to the relaxation of blood vessels. Fresh garlic was used at a concentration equal to eating two cloves. The resulting H[SUB]2[/SUB]S production caused up to 72 percent vessel relaxation in rat arteries.
This relaxation is a first step in lowering blood pressure and gaining the heart-protective effects of garlic, said David Kraus, Ph.D., a UAB associate professor in the Departments of Environmental Health Sciences and Biology and the study’s lead author.
The research team examined molecules in garlic called polysulfides and their ability to liberate H[SUB]2[/SUB]S within cells. The findings appear in the journal Proceedings of the National Academy of Sciences (PNAS).
“When these garlic compounds are metabolized to H[SUB]2[/SUB]S in the vascular system, the H[SUB]2[/SUB]S targets membrane channels and causes smooth muscle cells to relax,” Kraus said. “So a garlic-rich diet has many good effects, and H[SUB]2[/SUB]S may be the common mediator.”
The findings add to a study by John Elrod and David Lefer, Ph.D., of the Albert Einstein College of Medicine published in PNAS that showed H[SUB]2[/SUB]S protected hearts from the tissue and cell damage often seen in heart attack patients.
The new study, performed by Gloria Benavides, Ph.D., of UAB’s Department of Environmental Health Sciences, Kraus and others, is the first to show garlic-derived polysulfides in the diet boost bodily H[SUB]2[/SUB]S production.
H[SUB]2[/SUB]S is a toxic, flammable gas responsible for the smell of rotten eggs. It’s also produced naturally by the body in small amounts, and as age advances, H[SUB]2[/SUB]S production dwindles.
Exactly how H[SUB]2[/SUB]S affords the cardiovascular system so much protection is not entirely clear, but it may involve limiting oxidative damage in cells, Kraus said.
“The role of garlic compounds in preventing platelet aggregation, which can trigger a heart attack or stroke, and in limiting cancer growth and the progression of several diseases is well documented,” he said.
The new findings show H[SUB]2[/SUB]S may be the mediator for these protective benefits. Future studies are being planned to better understand how much H[SUB]2[/SUB]S production is needed through garlic or supplements to maximize those benefits.
The research is supported grants from the American Heart Association and the National Institutes of Health.

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Hydrogen sulfide mediates the vasoactivity of garlic


Abstract

The consumption of garlic is inversely correlated with the progression of cardiovascular disease, although the responsible mechanisms remain unclear. Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H[SUB]2[/SUB]S), an endogenous cardioprotective vascular cell signaling molecule. This H[SUB]2[/SUB]S production, measured in real time by a novel polarographic H[SUB]2[/SUB]S sensor, is supported by glucose-maintained cytosolic glutathione levels and is to a large extent reliant on reduced thiols in or on the RBC membrane. H[SUB]2[/SUB]S production from organic polysulfides is facilitated by allyl substituents and by increasing numbers of tethering sulfur atoms. Allyl-substituted polysulfides undergo nucleophilic substitution at the α carbon of the allyl substituent, thereby forming a hydropolysulfide (RS[SUB]n[/SUB]H), a key intermediate during the formation of H[SUB]2[/SUB]S. Organic polysulfides (R-S[SUB]n[/SUB]-R′; n > 2) also undergo nucleophilic substitution at a sulfur atom, yielding RS[SUB]n[/SUB]H and H[SUB]2[/SUB]S. Intact aorta rings, under physiologically relevant oxygen levels, also metabolize garlic-derived organic polysulfides to liberate H[SUB]2[/SUB]S. The vasoactivity of garlic compounds is synchronous with H[SUB]2[/SUB]S production, and their potency to mediate relaxation increases with H[SUB]2[/SUB]S yield, strongly supporting our hypothesis that H[SUB]2[/SUB]S mediates the vasoactivity of garlic. Our results also suggest that the capacity to produce H[SUB]2[/SUB]S can be used to standardize garlic dietary supplements.

http://www.pnas.org/content/104/46/17977.long

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[h=1]Onion juice (Allium cepa L.), a new topical treatment for alopecia areata.[/h]Sharquie KE, Al-Obaidi HK.
[h=3]Source[/h]Department of Dermatology and Venereology, Baghdad Teaching Hospital, Iraq.

[h=3]Abstract[/h]Alopecia areata is a patchy, non-scarring hair loss condition. Any hair-bearing surface may be involved, and different modalities of treatment have been used to induce hair regrowth. This study was designed to test the effectiveness of topical crude onion juice in the treatment of patchy alopecia areata in comparison with tap water. The patients were divided into two groups. The first group [onion juice treated] consisted of 23 patients, 16 males (69.5%) and 7 females (30.5%). Their ages ranged between 5-42 years with a mean of 22.7 years. The second group [control; tap-water-treated] consisted of 15 patients, 8 males (53.3%) and 7 females (46.6%). Their ages ranged between 3-35 years with a mean of 18.3 years. The two groups were advised to apply the treatment twice daily for two months. Re-growth of terminal coarse hairs started after two weeks of treatment with crude onion juice. At four weeks, hair re-growth was seen in 17 patients (73.9%), and, at six weeks, the hair re-growth was observed in 20 patients (86.9%) and was significantly higher among males (93.7%) compared to females (71.4%) P<0.0001. In the tap-water treated-control group, hair re-growth was apparent in only 2 patients (13%) at 8 weeks of treatment with no sex difference. The present study showed that the use of crude onion juice gave significantly higher results with regard to hair re-growth than did tap water (P<0.0001), and that it can be an effective topical therapy for patchy alopecia areata.

 

[hielo14]

that's very interesting ... I did'nt know that onions had with such great properties !!!
I remember that I checked a product some months ago with onions ... let me try to find back the name !

 

[squeegee]

Chickens.
Effect of aged garlic extract on wound healing: a new frontier in wound management.
Ejaz S, Chekarova I, Cho JW, Lee SY, Ashraf S, Lim CW.
Department of Clinical Neurosciences, Neurology Unit, Addenbrookes Hospital, University of Cambridge, Cambridge, UK. se298@cam.ac.uk


Successful wound healing depends upon angiogenesis, and impaired angiogenesis is a hallmark of the chronic wounds encountered with diabetes and venous or arterial insufficiency. To intervene and improve wound closure, it is essential to investigate the effects of different natural remedies in wound healing. The chicken dorsum skin excisional wound assay was used to investigate the influence of different concentrations of aged garlic solution (AGS) on wound healing. Gross, histopathology, scanning electron microscopy (SEM) and computer-based three-dimensional (3D) image-probing techniques were utilized to determine the effects of AGS on wound closure, re-epithelialization, dermal matrix regeneration, and angiogenesis. Ninety chicks, aged 1 week and divided in 6 groups, were topically exposed to different concentrations of AGS for 6 days: control (group A), 1% (group B), 5% (group C), 10% (group D), 15% (group E), and skin lotion (group F). Different patterns, ranging from incomplete to almost complete wound closure, were observed among different groups with highly significant results (P < 0.001) in group E. Histological investigations revealed a positive augment in the re-epithelialization of all AGS exposed wounds. An increase in the number of new loosely packed collagen and maturation of collagen bundles was observed in all treated wounds at days 4 and 6 post-wounding, respectively. Similar results were achieved through SEM of treated wounds. Histological investigations revealed the profuse dose-dependent neovascularization among AGS-treated wounds. Abbott curve, angular spectrum, and different parameters of 3D surface roughness of wounds were also measured for the precise quantification of angiogenesis. A very highly significant (P < 0.001) increase in angiogenesis was observed among all treated groups. No significant change was observed among control and skin lotion-treated groups. These observations substantiate the beneficial use of AGS in the treatment of wounds. Additional studies are needed to study the specific wound-healing mechanisms of chemical, or group of chemicals, present in AGS.

 

[squeegee]

Free radical biology and medicine: it's a gas, man!

Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, Davies KJ.
Source

Biodynamics Institute, Louisiana State University, Baton Rouge, LA 70803, USA. wpryor@LSU.edu

Abstract

We review gases that can affect oxidative stress and that themselves may be radicals. We discuss O(2) toxicity, invoking superoxide, hydrogen peroxide, and the hydroxyl radical. We also discuss superoxide dismutase (SOD) and both ground-state, triplet oxygen ((3)O(2)), and the more energetic, reactive singlet oxygen ((1)O(2)). Nitric oxide ((*)NO) is a free radical with cell signaling functions. Besides its role as a vasorelaxant, (*)NO and related species have other functions. Other endogenously produced gases include carbon monoxide (CO), carbon dioxide (CO(2)), and hydrogen sulfide (H(2)S). Like (*)NO, these species impact free radical biochemistry. The coordinated regulation of these species suggests that they all are used in cell signaling. Nitric oxide, nitrogen dioxide, and the carbonate radical (CO(3)(*-)) react selectively at moderate rates with nonradicals, but react fast with a second radical. These reactions establish "cross talk" between reactive oxygen (ROS) and reactive nitrogen species (RNS). Some of these species can react to produce nitrated proteins and nitrolipids. It has been suggested that ozone is formed in vivo. However, the biomarkers that were used to probe for ozone reactions may be formed by non-ozone-dependent reactions. We discuss this fascinating problem in the section on ozone. Very low levels of ROS or RNS may be mitogenic, but very high levels cause an oxidative stress that can result in growth arrest (transient or permanent), apoptosis, or necrosis. Between these extremes, many of the gasses discussed in this review will induce transient adaptive responses in gene expression that enable cells and tissues to survive. Such adaptive mechanisms are thought to be of evolutionary importance.

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A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide.


http://www.ncbi.nlm.nih.gov/pubmed/17991773?dopt=Citation

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[h=1]Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats.[/h]Kim-Park S, Ku DD.
[h=3]Source[/h]Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 35294, USA. SKIMPARK@UAB.EDU

[h=3]Abstract[/h]1. The aims of the present study were to determine the characteristics of garlic extract-induced relaxation in rat isolated pulmonary arteries, its susceptibility to changes in oxygen tension and its protective effect against hypoxic pulmonary vasoconstriction. 2. In normoxia, garlic extract (3-500 microg/mL) produced a dose- and nitric oxide (NO)-dependent relaxation. Following 60 min hypoxia, maximum garlic relaxation was reduced compared with control (mean (-SEM) -86 +/- 3 vs-69 +/- 2% of phenylephrine (PE) precontraction, respectively), but recovered after 60 min reoxygenation (-85 +/- 3% PE precontraction). 3. Acetylcholine (0.1 micromol/L)-induced NO-dependent relaxation was reduced from a control value of -76 +/- 1% to -46 +/- 4% during hypoxia and was further reduced to -35 +/- 2 % after reoxygenation. 4. In endothelium-intact arteries, hypoxic exposure resulted in a triphasic response: early transient contraction (+24 +/- 4%), followed by transient relaxation (-37 +/- 7%) and then sustained contraction (+62 +/- 5%). 5. Pretreatment with NG-nitro-L-arginine methyl ester abolished the early transient contraction, moderately attenuated the sustained contraction and had no effect on the transient relaxation. Mechanical endothelial disruption inhibited all hypoxia-induced vascular changes. 6. Garlic pretreatment had no effect on the early transient contraction (+25 +/- 4%), but inhibited the transient relaxation (-5 +/- 3%; P<0.05) and the sustained contraction (+26 +/- 5%; 7. Garlic also significantly inhibited endothelin-l-induced contractions in a dose-dependent manner. 8. These findings show that garlic extract modulates the production and function of both endothelium-derived relaxing and constricting factors and this may contribute to its protective effect against hypoxic pulmonary vasoconstriction.

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[h=1]Garlic prevents hypoxic pulmonary hypertension in rats.[/h]Fallon MB, Abrams GA, Abdel-Razek TT, Dai J, Chen SJ, Chen YF, Luo B, Oparil S, Ku DD.
[h=3]Source[/h]Liver Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA.

[h=3]Abstract[/h]Hypoxic pulmonary vasoconstriction underlies the development of high-altitude pulmonary edema. Anecdotal observations suggest a beneficial effect of garlic in preventing high-altitude symptoms. To determine whether garlic influences pulmonary vasoconstriction, we assessed the effect of garlic on pulmonary pressures in rats subjected to alveolar hypoxia and on vasoconstriction in isolated pulmonary arterial rings. Garlic gavage (100 mg/kg body wt) for 5 days resulted in complete inhibition of acute hypoxic pulmonary vasoconstriction compared with the control group. No difference in mean arterial pressure or heart rate response to hypoxia was seen between the groups. Garlic solution resulted in a significant dose-dependent vasorelaxation in both endothelium-intact and mechanically endothelium-disrupted pulmonary arterial rings. The administration of NG-nitro-L-arginine methyl ester (a nitric oxide synthase inhibitor) inhibited the vasodilatory effect of garlic by 80%. These studies document that garlic blocks hypoxic pulmonary hypertension in vivo and demonstrate a combination of endothelium-dependent and -independent mechanisms for the effect in pulmonary arterial rings.

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[h=1]Effects of onion extract on endogenous vascular H2S and adrenomedulin in rat atherosclerosis.[/h]Li W, Tang C, Jin H, Du J.
[h=3]Source[/h]Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

[h=3]Abstract[/h][h=4]OBJECTIVE:[/h]This study aimed to explore the effect of onion extract on endogenous hydrogen sulfide (H2S) and adrenomedulin (ADM) and on atherosclerotic progression in rats with atherosclerosis (AS).
[h=4]METHODS AND RESULTS:[/h]Male Sprague-Dawley rats were randomly divided into control, AS and AS+onion groups. Ultrastructure of aorta and atherosclerotic lesions both in aorta and in coronary artery were detected. Plasma and aortic H2S were detected by using a sulfide- sensitive electrode. Plasma and aortic ADM was determined with radioimmunoassay. Cystathionine-γ-lyase (CSE), calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein (RAMP1, RAMP2 and RAMP3) mRNA expressions were analysed. Glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and NO synthase (NOS) contents in plasma, SOD1, SOD2 and ICAM-1 expressions in aorta were detected. Rats in the AS group showed marked atherosclerotic lesions both in aorta and in coronary artery but decreased aortic H2S production. Decreased plasma and aortic ADM content, but increased levels of aortic CRLR, RAMP2 and RAMP3 mRNAs were observed. Plasma GSH-PX and SOD were reduced but MDA elevated. Plasma ICAM-1 and NO contents and iNOS activity were increased. Onion extract, however, lessened atherosclerotic lesions and increased endogenous aortic H2S production, but decreased plasma ADM content, aortic ADM content and aortic CRLR, RAMP2 and RAMP3 mRNAs. In addition, it increased plasma GSH-PX level and SOD activities but reduced MDA; it decreased inflammatory response but increased plasma eNOS activity and NO content.
[h=4]CONCLUSIONS:[/h]Onion extract exerted a marked antiatherogenic effect in association with the up-regulation of the endogenous CSE/H2S pathway but down-regulation of the ADM/CRLR family in atherosclerotic rats.

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[h=1]S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway.[/h]Chuah SC, Moore PK, Zhu YZ.
[h=3]Source[/h]Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, China.

[h=3]Abstract[/h]S-allylcysteine (SAC) is an organosulfur-containing compound derived from garlic. Studies have shown that garlic is beneficial in the treatment of cardiovascular diseases. This study aims to elucidate if SAC is responsible for this cardioprotection using acute myocardial infarction (AMI) rat models. In addition, we hypothesized that SAC may mediate cardioprotection via a hydrogen sulfide (H(2)S)-related pathway. Rats were pretreated with saline, SAC (50 mg x kg(-1) x day(-1)), SAC + propagylglycine (PAG; 50 mg + 10 mg x kg(-1) x day(-1)) or PAG (10 mg x kg(-1) x day(-1)) for 7 days before AMI induction and killed 48 h after. Our results showed that SAC significantly lowered mortality (12.5% vs. 33.3%, P < 0.05) and reduced infarct size. SAC + PAG- and PAG-treated rats had larger infarct sizes than controls (60.9 +/- 0.01 and 62.0 +/- 0.03%, respectively, vs. 50.0 +/- 0.03%; P < 0.05). Pretreatment with SAC did not affect BP, but BP was significantly elevated in SAC + PAG and PAG-treated groups (P < 0.05). In addition, plasma H(2)S levels and left ventricular cystathionine-gamma-lyase (CSE) activities were analyzed to investigate the involvement of H(2)S. CSE is the enzyme responsible for H(2)S production in the heart. SAC increased left ventricular CSE activity in AMI rats (2.75 +/- 0.34 vs. 1.23 +/- 0.16 micromol x g protein(-1) x h(-1); P < 0.01). SAC + PAG-treated rats had significantly lower CSE activity compared with the SAC-treated group (1.22 +/- 0.27 vs. 2.75 +/- 0.34 micromol x g protein(-1) x h(-1); P < 0.05). Similarly, SAC-treated rats had higher plasma H(2)S concentration compared with controls and the SAC + PAG-treated group. Protein expression studies revealed that SAC upregulated CSE expression (1.1-fold of control; P < 0.05), whereas SAC + PAG and PAG downregulated its expression (0.88-fold of control in both groups; P < 0.005). In conclusion, our study provides novel evidence that SAC is protective in myocardial infarction via an H(2)S-related pathway.

 

[researchingeverything]

I don't think that you need onion juice to get the same results.. Sublimed Sulphur contain the same stuff. It is pure yellow sulphur..

http://www.amazon.com/Humco-sulfur-sublimed-powder-USP/dp/B000GCOLM0

Females on their hair growth forums swear by it..

where can i check the list of ingredients of that product?

 

[squeegee]

[h=1]Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation.[/h]Weiss N, Papatheodorou L, Morihara N, Hilge R, Ide N.
[h=3]Source[/h]Center for Vascular Medicine, Section Angiology, University of Munich Medical Center, City Campus, Munich, Germany. norbert.weiss@uniklinikum-dresden.de

[h=3]Abstract[/h][h=4]ETHNOPHARMACOLOGICAL RELEVANCE:[/h]Supplementation with aged garlic extract (AGE) has been shown to restore impaired endothelium-dependent vasodilator response in subjects with acutely elevated plasma homocysteine (Hcy) levels after an oral methionine load and in patients with chronic coronary artery disease. Moreover, AGE has been shown to inhibit the progression of coronary calcifications in patients with coronary artery disease. The molecular mechanisms, by which AGE preserves endothelial function is unknown. Our objective was to explore whether AGE preserves endothelial nitric oxide (NO) output even under conditions of elevated Hcy levels by preventing oxidative inactivation of the NO synthase cofactor tetrahydrobiopterin.
[h=4]MATERIAL AND METHODS:[/h]Endothelial (EA.hy 926) cells were incubated with hypoxanthine, aminopterin, thymidine and methionine (HAT/MET) to increase cellular Hcy levels, and with and without AGE. Agonist stimulated NO output was measured using the fluorescent probe DAF-2, and cellular thiol levels (Hcy, cysteine, reduced and oxidized glutathione) and cellular tetrahydrobiopterin levels were measured by high performance liquid chromatography.
[h=4]RESULTS:[/h]HAT/MET incubation resulted in significantly increased cellular Hcy levels, unaffected by coincubation with AGE. Elevated Hcy went along with significantly decreased NO output (to 34.4 ± 4.4% of control) and levels of tetrahydrobiopterin (from 4.67 ± 2.17 to 2.17 ± 0.97 pmol/mg). Incubation with AGE (5mg/mL) in HAT/MET-treated cells prevented the declines in NO output and tetrahydrobiopterin levels. AGE increased cellular levels of cysteine and total glutathione, and prevented glutathione and tetrahydrobiopterin oxidation induced by elevated Hcy.
[h=4]CONCLUSION:[/h]Incubation with AGE preserved normal NO output from endothelial cells even under conditions of elevated Hcy levels by increasing cellular thiol antioxidant and prevention of tetrahydrobiopterin oxidation. This suggests that AGE might be useful in the prevention of endothelial dysfunction.

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[h=1]Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries.[/h]Ku DD, Abdel-Razek TT, Dai J, Kim-Park S, Fallon MB, Abrams GA.
[h=3]Source[/h]Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Alabama 35294, USA. DavidKu@UAB.EDU

[h=3]Abstract[/h]1. The aims of the present study were to investigate the effects of fresh garlic and one of its active metabolites, allicin, on rat isolated pulmonary arteries (RPA). 2. In endothelium-intact and phenylephrine-precontracted RPA, the addition of a water or a 5% ethanol extract of fresh garlic (1-500 microg/mL) resulted in a dose-dependent relaxation reaching a maximum (mean +/- SEM) of -91 +/- 3 and -93 +/- 2%, respectively, with an ED(50) of 113 +/- 12 and 106 +/- 10 microg/mL, respectively. The vasorelaxation was readily reversible upon washing and no tachyphylaxis was noted. 3. An extract of the external garlic storage leaf produced a significantly greater relaxation than the inner stem. Microfiltration of extracts with a 10,000 molecular sieve did not attenuate relaxation. Inactivation of alliinase and allicin formation, with either boiling of the garlic clove for 30 min or 100% ethanol treatment, completely abolished relaxation. In contrast, similar treatment of crushed garlic with formed allicin retained the relaxation response. 4. Pure allicin produced a similar relaxation as garlic extract, with an EC(50) of approximately 0.8 microg/mL. Disruption of endothelium or N(G)-nitro-L-arginine methyl ester pretreatment attenuated the relaxation, whereas indomethacin had no effect. 5. Prior garlic (500 microg/mL) treatment enhanced acetylcholine relaxation by shifting the response curve to the left, but had no effect on nitric oxide (NO) donor-induced responses. 6. These results demonstrate that garlic and the active metabolite allicin are capable of eliciting a NO-dependent relaxation in RPA and that this response is likely to be mediated via garlic activation of NO formation rather than its stabilization.

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[h=1]Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide.[/h]Ashraf MZ, Hussain ME, Fahim M.
[h=3]Source[/h]Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, PO Box 2101, Delhi 110007, India.

[h=3]Abstract[/h]The vasorelaxant effect of garlic (Alium sativum L.) has been suggested to be partially mediated through endothelium. The present study was designed to evaluate the role of various endothelium-mediated mechanisms in vasorelaxant response of garlic on isolated aortic rings of rats. In tissues precontracted with phenylephrine (PE) 10(-6)M, concentration-response curve for different concentrations of garlic (1, 5, 10, 20 and 50 microg/ml) was examined. In all the preparations garlic showed a concentration-dependent vasorelaxant response. There was a significant attenuation of vasorelaxation in tissues pretreated with K(+) channel blocker, glybenclamide (10(-6)M). Indomethacin (10(-5)M) enhanced the relaxant response of garlic. N(G)-Monomethyl-L-arginine (L-NMMA) 30 microM, a potent inhibitor of nitric oxide synthase, did not produce any significant effect on the response of garlic. However, cGMP blocker methylene blue (10(-5)M) showed a strong vasoconstriction and inhibited the vasorelaxant response of garlic. The results indicate that endothelium modulated vasorelaxation of garlic is partly mediated through EDHFs and cycloxygenase pathways. However, relaxing factor(s) other than NO, mediated through cGMP has a major role in the vasorelaxant response of garlic.

 

[saintsfan92344]

If I can give u advices,

Wash your hair after applying onion,
don't let your hair with onions all night, because your hair skin will be so bad after it
I tried and it gave me so much sheddingo

mayb applying onion after dermaroller is a great idea

I have a feeling that would burn like a mutha.

 

[hairregrowth21]

What is the difference between onion juice and mederma? I tried applying onion slices topically with a heat wrap for an hour and it caused itching/irritation...

Adding mederma would theoretically make sense as an add-on to the dermaroller routine...thoughts?

 

[squeegee]

What is the difference between onion juice and mederma? I tried applying onion slices topically with a heat wrap for an hour and it caused itching/irritation...

Adding mederma would theoretically make sense as an add-on to the dermaroller routine...thoughts?

LOL... onions are acidic!

 

[Dikek]

I just found a random comment about this solution on YouTube, almost every comments are very positive about this, no one did a long term experiment about onion/ garlic juice?

If we come out with something which work well for the awful smell we could have a powerful weapon against Androgenetic Alopecia, seems it works in few weeks!

 

[Dragon Lord]

Hey! I know these posts are really old, and I'm currently late to the discussion, but I wanted to provide this information as I am a current victim to Male pattern baldness. (or maybe not anymore!)

So basically, I'm a 19 year old Law undergraduate living in the UK. and basically a year and a half ago I noticed some slight miniaturisation of hairs growing smaller and smaller as time went by. I didn't think much of it, as I didn't understand male pattern baldness as I had just turned 18 and was living life. But I am a sceptical individual I over analyse everything! I also loved staring at myself in the mirror (still do) so I pretty early noticed that these hairs were not coming back.

As this took place, I opened my laptop and was determined to find a cure or the root to my problem. Turns out I have MBP as my temples have receded a bit. I went online where it said "Oh it's only your hairline maturing it doesn't matter it's normal" Well I called that bull crap. As I'm a perfectionist and Like I said over analytical so me being me I didn't believe it. I followed my quest with days and days of research. I don't use minoxidil or Rogain because I'm not about putting chemicals in my body to f*** up my hormones and limit the DHT in my body as DHT has some benefits to your body too.

So the game being played with my life is to limit as much DHT without it affecting my body in a negative way, I've followed lot's of forums including this one, I watched websites of people claiming to have found a cure. (I'm not stupid enough to buy their products) and watching YouTube videos. Most were useless until I found Onion juice. At first I thought it was a troll.

However, I was sceptical because I believe the best products for our body are mostly all natural. So I had to try I But I didn't know how, when, to use it. So I did a bulk of research on it. And on my birthday I started using Onion juice. Not just that, I mix it with garlic juice, and on alternative days I use Nizorall shampoo. I did this for a whole year everyday. Yes a WHOLE YEAR! (I also use an expensive juicer don't use any other method of juicing or it will mess your skin up turn it black I have seen people claiming it has messed up their skin, Although I believe its because they were using the wrong method of extracting the juice. Get a juicer people!!)

Well then, I put this onion juice mix on at night before bed, put a towel on my pillow and when I wake up its hardened, I go in the shower and use nizorall shampoo on the first day. BOOM smell is gone. (you don't smell while you sleep so I don't know what people complain about) On other days I use coconut oil after washing my hair. and not use shampoo. (Very bad to use shampoo everyday stop if you do)

RESULTS
It was slow, which is believable because its a natural cure and as it takes time to bald, It will take time to grow back. After the year, I have grown hairs all over my hairline. Not just that. I have grown hairs on my hairline where I didn't even realise I had hair! I didn't go to the barber for a shape up or anything so I could clearly see if it working. It started on the bottom of the M hair first starts to appear, then it starts to appear all over your temples very small you need a good light to see them. And eventually they grow and fall out YES FALL OUT! and then they grow back quicker and stronger then before. And all the little hairs next to it grow at different times. So while some are big and thick some are still small and weak. As each hair has its own hair cycle. I used the shampoo to reduce the DHT in my scalp. And I also stopped masturbation completely as I used to masturbate 2-3 a week. And noticed the already slow process is even slower when you masturbate and I found this study online that DHT levels spike when you masturbate. I used to get about 50-60 hair falling out of my head everyday. When I used to massage it with shampoo in shower and before bed. Now I have 2-3 hairs fall out in shower while massage and 2-3 when I massage with onion juice. My hair health has improved ALOT! And I still have new hairs growing in everyday where I didn't think I had hair before on my hairline.

This year, I'm doing the same regime but also limiting on sugar, keeping my sugar levels balanced. As the past year I clogged up on sugar and didn't give my hair enough nutrients. (Lets see if it helps!) I also found a 50 year old on YouTube who regrew all his hair with the help of onion juice. I will leave a link down below. While I conducted my research Iv noticed the human race is very evil. We laugh at others insecurities, make money of them, and troll them. 90% of my research were unintellectual individuals who tried to use others insecurity to make a quick buck. Hairloss is a very downgrading thing, it kills people's confidence makes them desperate, nobody deserves to be like that. We should all be happy So I hope this helps to anyone in need for a fix. I can't guarantee it will work for you. But It will give you a very big fighting chance with no side affects. Good Luck.!!

 

[Armando Jose]

Thank you for your report

Which quantity did you use?

If it is possible, a photo is wellcome.

 

[Dazz_nz]

Id be pretty interested to see your pics too (im not doubting you - just curious). I watched that guys vids last year, only things though as he doesnt have normal Androgenetic Alopecia. He says it himself in one of the videos and he has no history of baldness in his family either.

 

[Ywg]

Something from Europe.