Anyone try adding thyme oil to minoxidil and used it consistently for 2-3 months? Bernie @ HS had impressive before/after pics but he was on the big three with thyme oil + some other stuff.
Born.. Do you have a link for HS ?? Carvacrol is the magic ingredient in Thyme oil BTW. Thyme smell hard core. Oregano oil should be a better candidate for hairloss.
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis.
Landa P,
Kokoska L,
Pribylova M,
Vanek T,
Marsik P.
Source
Joint Laboratory of Institute of Experimental Botany AS CR, Prague 6 - Lysolaje, Czech Republic.
Abstract
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E(2) catalysed by COX-2 with an IC(50) value of 0.8 microM what is practically the same concentration as the IC(50) obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 microM and 0.8 microM, respectively. The COX-1 was inhibited approximately at the same rate (IC(50) of 0.7 microM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms.
The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression.
Hotta M, Nakata R, Katsukawa M, Hori K, Takahashi S, Inoue H.
Source
Department of Food Science and Nutrition, Nara Women's University Nara 630-8506 Japan.
Abstract
Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor superfamily and are involved in the control of COX-2 expression, and vice versa. Here, we show that COX-2 promoter activity was suppressed by essential oils derived from thyme, clove, rose, eucalyptus, fennel, and bergamot in cell-based transfection assays using bovine arterial endothelial cells. Moreover, from thyme oil, we identified carvacrol as a major component of the suppressor of COX-2 expression and an activator of PPARalpha and gamma. PPARgamma-dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment. In human macrophage-like U937 cells, carvacrol suppressed lipopolysaccharide-induced COX-2 mRNA and protein expression, suggesting that carvacrol regulates COX-2 expression through its agonistic effect on PPARgamma. These results may be important in understanding the antiinflammatory and antilifestyle-related disease properties of carvacrol.