Boldy said:PGE2 sounds very promising for me.
http://onlinelibrary.wiley.com/doi/10.1 ... 586.x/fullThe PGE2 and PGF2? were also described as possible modulators of hair growth. Indeed, topical use of viprostol, a PGE2 analogue, was reported to increase human hair growth and terminal hair counts after 50 weeks treatment (11) while administration of 16,16-dimethyl PGE2 protected mice from radiation-induced alopecia (12). Minoxidil, a potent trichogenic agent, was found to enhance prostaglandin endoperoxide synthase-1 (PGHS-1) activity, suggesting a link between prostaglandin synthesis and hair growth (13), as later confirmed by the role of PGHS-2 in the control of hair cycle (14). Latanoprost, a PGF2? analogue used to treat glaucoma, was reported to induce hypertrichosis in humans (15) and stump-tailed macaque (16). Moreover, as isopropyl unoprostone and PGF2?, it stimulated conversion from the telogen to the anagen phase in mice model (17). On the contrary, cyclooxygenases (COX)-2 overexpression induced a reduction in hair follicle density and delayed postnatal hair follicle morphogenesis in transgenic mice compared with wild-type animals while COX-2 inhibitors restored normal hair growth (18,19).
What I don't understand in "the puzzle" is why testosterone/DHT grows body hair and beard but shrinks scalp hair.Boldy said:2020 said:there's not much you can research.... we need scientists to actually conduct experiments and then learn from that.
For example: what would happen if you applied large amounts of PGD2 on your donor hair? Will it shrink?
find a bunch of castrated people. Measure their PGD2 levels on their scalp.
.... on and on.... I don't see why they couldn't do so many obvious experiments over the weekend or something...
still, we could learn allot, there are thousands of studies on pubmed, that can bring us closer to solve the puzzle, for example, we now know PGF2 alpha increases testosterone more then 100%, these levels are elevated in the scalp. while PG2E, should do the opposite with testosterone(not sure yet have to read more), wich these levels are down regulated.
We need the perfect solution for full regrowth.
It's precisely the topic of the study... :smack:odalbak said:
Are prostaglandins useful as a whole for hair growth? Or is PGE2 (and possibly other prostaglandin forms) only beneficial because they counteract PGD2 and PGF2?
Anyone that can answer this question please do.
In contrast to PGD2, the level of prostaglandin E2 (PGE2), which is synthesized by PTGES rather than PTGDS, was more abundant in haired scalp compared to balding scalp (Fig. 2E), with 3.1 ng/g balding scalp and 6.4 ng/g haired scalp as detected by UHPLC-MS (Fig. 2F).
Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2?.
There is precedence for the opposing functions of individual prostaglandins that are downstream from the PTGS enzymes. For example, in the lung, PGE2 causes relaxation, whereas PGD2 causes contraction of bronchial muscle tone (16). Our results suggest that in mouse and human skin, a balance between PGE2 and PGD2 controls hair growth. This model predicts then that efforts to reverse alopecia should optimally focus on both enhancing PGE2 and inhibiting PGD2 signaling. This model also explains why agents such as aspirin, which inhibit upstream prostaglandin synthesis enzymes (PTGS1 and PTGS2), have minimal effects on hair growth because of likely equally decreased production of PGE2 and PGD2.
nfire: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/Our findings also suggest that supplemental PGE2 could be therapeutic. By correcting its deficiency and increasing its level in bald scalp, the inhibitory effects of PGD2 may be overcome. Analogs of PGF2?, which are already FDA-approved to promote eyelash growth, should also have similar effects on the scalp and are currently in clinical trials for this indication.
Saint-Loup said:Transdermal viprostol in the treatment of male pattern baldness
Fifty-seven men were randomly assigned for treatment of androgenetic alopecia with viprostol, vehicle, or placebo twice daily for 24 weeks. Nonvellus hair growth was assessed subjectively by both patient and investigator and objectively through hair counts from macrophotographs of the target area. Nonvellus target area hair counts declined in all three treatment groups at the end of the 6-month study. Viprostol is not an effective hair growth promoter in androgenetic alopecia.
1990 Sep
http://www.ncbi.nlm.nih.gov/pubmed/2212146
2020 said:ugh... PGF2 IS GOOD FOR YOU. Hairy people have it and it works for them in a positive way. Why would it work in a negative way for us???
Boldy said:why are the new transplanted hairs surviving the excess PGD2 in the temple area.
2020 said:ugh... PGF2 IS GOOD FOR YOU. Hairy people have it and it works for them in a positive way. Why would it work in a negative way for us???
odalbak said:Boldy said:why are the new transplanted hairs surviving the excess PGD2 in the temple area.
I reckon it's because it takes years for healthy follicles to be observably affected by PGD2's presence up there, all the more since transplants are done on mature men with lower testosterone production.
2020 said:ugh... PGF2 IS GOOD FOR YOU. Hairy people have it and it works for them in a positive way. Why would it work in a negative way for us???
Bimatoprost helps with eyelashes by increasing PGF2, but PGF2 also increases testosterone by 100%. No problem for eyelashes. Maybe not so good for scalp hair… This has already been mentioned by Boldy a few posts ago.
Boldy said:We Androgenetic Alopecia people have 50% lower PGE2 Values.
odalbak said:Boldy said:We Androgenetic Alopecia people have 50% lower PGE2 Values.
Sources?