Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?

[Koga]

Re: A recently discovered new factor in AA, the cure is near

That's what I've heard too, Aspirin blocks the production of PGE-2 as well and PGE-2 is necessary for healthy hair growth. You don't wanna block this; just PGD-2.

 

[Loomis]

Re: A recently discovered new factor in AA, the cure is near

But you said "know" and you didn't back that up with anything.

Well we "know" PGE2 is essential for hair growth, and as I posted in the quote from the PGD2 study, aspirin like substances reduce PGE2 and PGD2, that won't help us at all, we need to inhibit PGD2 and increase PGE2, so we "know" that anything reducing PGE2 isn't of any use to us.

But if you want to take it, by all means fill your boots.

 

[sapinho]

Re: A recently discovered new factor in AA, the cure is near

He's only talking about blocking COX2, which basically means he's blocking a major pathway to inflammation.

You'll still get PGE2 from normal COX1 levels. Yes, many things online talk about rising PGE2 levels due to rising COX2. PGE2 goes hand-in-hand with inflammation so much that this is another metric of inflammation, but that doesn't mean it's ONLY produced by COX2.

His theory is that the high PGD2 levels come from COX2, not COX1. We'll see...

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Celecoxib is basically an Aspirin-like drug.

Aspirin was derived from White Willow Bark.

Just buy White Willow Bark extract and top off a bottle of Minoxidil. That's what I'm going to do … maybe the end of this month.

Celecoxib is a NSAID selective COX-2 inhibitor.Primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production), whereas nonselective NSAIDs (like asprin, naproxen and ibuprofen) inhibit both COX-1 and COX-2.

http://en.wikipedia.org/wiki/Cyclooxyge ... evelopment
http://en.wikipedia.org/wiki/COX-2_selective_inhibitor

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

Why would you try to reduce PGD2, If you could do it more efficiently by targeting the one and only target receptor. CRTH2 antagonist should be the most efficient way to get rid of the inflammatory properties of PGD2.

I will try OC000459 very soon.

Reducing cox2, will also reduce a battery of essential prostaglandins.

 

[Saint-Loup]

Re: A recently discovered new factor in AA, the cure is near

Celecoxib is basically an Aspirin-like drug.

Aspirin was derived from White Willow Bark.

Just buy White Willow Bark extract and top off a bottle of Minoxidil. That's what I'm going to do … maybe the end of this month.

Celecoxib is a NSAID selective COX-2 inhibitor.Primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production), whereas nonselective NSAIDs (like asprin, naproxen and ibuprofen) inhibit both COX-1 and COX-2.

http://en.wikipedia.org/wiki/Cyclooxyge ... evelopment
http://en.wikipedia.org/wiki/COX-2_selective_inhibitor

It seems to be a bad idea :

COX-1 was identified as the main isoform present in the dermal papilla (DP) of normal human hair follicle (either anagen or catagen) (5), whereas COX-2 was only faintly and exclusively expressed in anagen dermal papilla. Although COX-2 activity was found to be necessary for early growth of hair follicle (6)

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full

 

[Saint-Loup]

Re: A recently discovered new factor in AA, the cure is near

Celecoxib is basically an Aspirin-like drug.

Aspirin was derived from White Willow Bark.

Just buy White Willow Bark extract and top off a bottle of Minoxidil. That's what I'm going to do … maybe the end of this month.

be careful...

Inhibitors of prostaglandin endoperoxide synthase such as indomethacin, ibuprofen, and aspirin were shown to block PG synthesis and inhibit hair growth (3,4).

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

lots of info, lots of chemicals listed here

any of the experts fancy breaking it down a bit for me.


how do i nuke PGD2 ?

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Celecoxib is basically an Aspirin-like drug.

Aspirin was derived from White Willow Bark.

Just buy White Willow Bark extract and top off a bottle of Minoxidil. That's what I'm going to do … maybe the end of this month.

Celecoxib is a NSAID selective COX-2 inhibitor.Primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production), whereas nonselective NSAIDs (like asprin, naproxen and ibuprofen) inhibit both COX-1 and COX-2.

http://en.wikipedia.org/wiki/Cyclooxyge ... evelopment
http://en.wikipedia.org/wiki/COX-2_selective_inhibitor

It seems to be a bad idea :

COX-1 was identified as the main isoform present in the dermal papilla (DP) of normal human hair follicle (either anagen or catagen) (5), whereas COX-2 was only faintly and exclusively expressed in anagen dermal papilla. Although COX-2 activity was found to be necessary for early growth of hair follicle (6)

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full

You want to modulate/reduce prostaglandins... not stopping it.. A good start is by reducing Cox-2.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Celecoxib is basically an Aspirin-like drug.

Aspirin was derived from White Willow Bark.

Just buy White Willow Bark extract and top off a bottle of Minoxidil. That's what I'm going to do … maybe the end of this month.

be careful...

Inhibitors of prostaglandin endoperoxide synthase such as indomethacin, ibuprofen, and aspirin were shown to block PG synthesis and inhibit hair growth (3,4).

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full

Although COX-2 activity was found to be necessary for early growth of hair follicle (6), PG injection or PG excess induced anagen to catagen transition and alopecia.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Prostaglandin-induced hair growth.
Johnstone MA, Albert DM.
Source

Glaucoma Consultants Northwest, Swedish Medical Center, Seattle, WA 98104, USA.
Abstract

Latanoprost, used clinically in the treatment of glaucoma, induces growth of lashes and ancillary hairs around the eyelids. Manifestations include greater thickness and length of lashes, additional lash rows, conversion of vellus to terminal hairs in canthal areas as well as in regions adjacent to lash rows. In conjunction with increased growth, increased pigmentation occurs. Vellus hairs of the lower eyelids also undergo increased growth and pigmentation. Brief latanoprost therapy for 2-17 days (3-25.5 microg total dosage) induced findings comparable to chronic therapy in five patients. Latanoprost reversed alopecia of the eyelashes in one patient. Laboratory experiments with latanoprost have demonstrated stimulation of hair growth in mice and in the balding scalp of the stumptailed macaque, a primate that demonstrates androgenetic alopecia. The increased number of visible lashes is consistent with the ability of latanoprost to induce anagen (the growth phase) in telogen (resting) follicles while inducing hypertrophic changes in the involved follicles. The increased length of lashes is consistent with the ability of latanoprost to prolong the anagen phase of the hair cycle. Correlation with laboratory studies suggests that initiation and completion of latanoprost hair growth effects occur very early in anagen and the likely target is the dermal papilla.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

 

[Swopo]

Re: A recently discovered new factor in AA, the cure is near

what about this
http://www.ncbi.nlm.nih.gov/pubmed/19374166

Abstract

Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-alpha production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

what about this
http://www.ncbi.nlm.nih.gov/pubmed/19374166

Abstract

Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-alpha production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis.

cheap! http://www.iherb.com/Calendula-Organic- ... 60-ml/2844

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Topical ibuprofen stays in the tissues a long time so there is no need for frequent applications. Unfortunately, topical ibuprofen is not available as a product. There are a couple of ways to make an experimental topical ibuprofen gel. One way is to puncture an ibuprofen (Advil Liqui-Gel) gel cap and mix its contents with a glob of aloe vera gel. Mixing aloe vera and ibuprofen together results in a cloudy or milky substance that is quite acidic. Adding a few drops of household ammonia until the mixture becomes clear again neutralizes the acidity, but I am not sure if this affects the potency. Another way to make a topical ibuprofen gel is to grind regular ibuprofen caps and dissolve them in a small amount of alcohol (not isopropyl) overnight. The alcohol is then poured off and mixed with an equal volume of aloe vera gel.

 

[Jacob]

Re: A recently discovered new factor in AA, the cure is near

http://www.alivepluspharmacy.com/productinfo/Nurofen_Gel_50g?currency=USD&aid=GBUS

http://compare.ebay.com/like/300703730666?var=lv&ltyp=AllFixedPriceItemTypes&var=sbar&_lwgsi=y&cbt=y

http://www.vargooutdoors.com/PROFEN-HP-12835

http://www.naturallybetter.net/1ibuprofengel.html

http://bikestore.oversupplywarehous...ofen-Homeopathic-Topical-Cream-12-tubes_i7124

http://www.drleonards.com/Health-Products/Arthritis-Pain-Relief/Ibu-Relief-12/26694.cfm

:dunno:

The stupid-a** FDA is cracking down on these topical products...so don't be surprised if they're not available soon.

 

[Saint-Loup]

Re: A recently discovered new factor in AA, the cure is near

Topical ibuprofen stays in the tissues a long time so there is no need for frequent applications. Unfortunately, topical ibuprofen is not available as a product. There are a couple of ways to make an experimental topical ibuprofen gel. One way is to puncture an ibuprofen (Advil Liqui-Gel) gel cap and mix its contents with a glob of aloe vera gel. Mixing aloe vera and ibuprofen together results in a cloudy or milky substance that is quite acidic. Adding a few drops of household ammonia until the mixture becomes clear again neutralizes the acidity, but I am not sure if this affects the potency. Another way to make a topical ibuprofen gel is to grind regular ibuprofen caps and dissolve them in a small amount of alcohol (not isopropyl) overnight. The alcohol is then poured off and mixed with an equal volume of aloe vera gel.

be careful!

Inhibitors of prostaglandin endoperoxide synthase such as indomethacin, ibuprofen, and aspirin were shown to block PG synthesis and inhibit hair growth (3,4).

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full
3) Alopecia Associated With Ibuprofen http://jama.ama-assn.org/content/242/2/142.2.extract
4) Drug-associated alopecia http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

Topical ibuprofen stays in the tissues a long time so there is no need for frequent applications. Unfortunately, topical ibuprofen is not available as a product. There are a couple of ways to make an experimental topical ibuprofen gel. One way is to puncture an ibuprofen (Advil Liqui-Gel) gel cap and mix its contents with a glob of aloe vera gel. Mixing aloe vera and ibuprofen together results in a cloudy or milky substance that is quite acidic. Adding a few drops of household ammonia until the mixture becomes clear again neutralizes the acidity, but I am not sure if this affects the potency. Another way to make a topical ibuprofen gel is to grind regular ibuprofen caps and dissolve them in a small amount of alcohol (not isopropyl) overnight. The alcohol is then poured off and mixed with an equal volume of aloe vera gel.

be careful!

Inhibitors of prostaglandin endoperoxide synthase such as indomethacin, ibuprofen, and aspirin were shown to block PG synthesis and inhibit hair growth (3,4).

http://onlinelibrary.wiley.com/doi/10.1 ... 639.x/full
3) Alopecia Associated With Ibuprofen http://jama.ama-assn.org/content/242/2/142.2.extract
4) Drug-associated alopecia http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract

If we have x3 times the norm.. What is the big deal about this? If you have no hairloss and abuse on Ibuprofen.. I can see a problem. Although COX-2 activity was found to be necessary for early growth of hair follicle (6), PG injection or PG excess induced anagen to catagen transition and alopecia.

 

[Saint-Loup]

Re: A recently discovered new factor in AA, the cure is near

OK

On the contrary, cyclooxygenases (COX)-2 overexpression induced a reduction in hair follicle density and delayed postnatal hair follicle morphogenesis in transgenic mice compared with wild-type animals while COX-2 inhibitors restored normal hair growth (18,19).

http://onlinelibrary.wiley.com/doi/10.1 ... 586.x/full

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

http://www.alivepluspharmacy.com/productinfo/Nurofen_Gel_50g?currency=USD&aid=GBUS

http://compare.ebay.com/like/300703730666?var=lv&ltyp=AllFixedPriceItemTypes&var=sbar&_lwgsi=y&cbt=y

http://www.vargooutdoors.com/PROFEN-HP-12835

http://www.naturallybetter.net/1ibuprofengel.html

http://bikestore.oversupplywarehous...ofen-Homeopathic-Topical-Cream-12-tubes_i7124

http://www.drleonards.com/Health-Products/Arthritis-Pain-Relief/Ibu-Relief-12/26694.cfm

:dunno:

The stupid-a** FDA is cracking down on these topical products...so don't be surprised if they're not available soon.

Jacob! I bought Ibuprofen gel capsules today for cheap at the drugstore.. I mixed it with aloe vera (Cox 2 inhibitor as well).. works really good. I also tried it with Diclofenac sold under Voltaren.. which is another Cox 2 inhibitor..works good as well.