thought oral spironolactone induce feminization (?)
I say dont bother. From my experience its not near the effectiveness of finasteride. If it was everyone would be on topical spironolactone instead with no systemic sides and with success stories. It might work but I dont think the vehicle or chemical gets absorbed or used properly or its just not strong enough. Its one of those chemicals you wished would work better than it seems to in practice.
Clinical evaluations of topical applications of spironolactone concluded that "as far as the topical use is concerned spironolactone seems to be highly effective with absence of systemic effects" Messina M, Manieri C, Musso MC, Pastorino R.: Oral and topical spironolactone therapies in skin androgenization. Panminerva Med, 1990 Apr-Jun,32:2,49-55I thought its long been accepted topical spironolactone is useless.
NO, and the reason is that spironolactone is (a) not very stable in solution. And (b) spironolactone+minoxidil solution results in an extremely malodorous solution. BTW I will be starting topical spironolactone in a custom made vehicle (no cream) very soon. However, not instead of finasterdie but rather adjuvant. And because I have used spironolactone systemically already, I will instantly know if it works or not.BTW can we mix crushed spironolactone tabs to liquid minoxidil and hope it works properly??
NO, and the reason is that spironolactone is (a) not very stable in solution. And (b) spironolactone+minoxidil solution results in an extremely malodorous solution. BTW I will be starting topical spironolactone in a custom made vehicle (no cream) very soon. However, not instead of finasterdie but rather adjuvant. And because I have used spironolactone systemically already, I will instantly know if it works or not.
It was only a brief test drive, for about 40 days (50mg/d); I was ordering avodart (dutasteride) at an online pharmacy and they were also selling spironolactone (quite cheep), so I took the opportunity and ordered some (20x100mg) out of curiosity. So, the most notable positive effect I can remember was a strengthening of hair (pull test) and also it felt fuller and with an improved 'bounce'. There were also mild sides, most notably slightly decreased libido and increased fatigue. Back to present - the vehicle for the spironolactone (2%) will be something like the K&B solution that Kane is selling for his RU. Pure (isolated) spironolactone and only small batch at a time. Three months of resource.How long were you on oral spironolactone? What solution are you making?