New Prostaglandins (PGD2 and PGI2) study

[ElToso]

The role of prostaglandins in androgenetic alopecia - PubMed

These results support that there is a fine balance between these four proteins in scalp hair follicles, and its maintenance may be crucial for hair growth. Furthermore, their receptors could be potential targets for treatment of Androgenetic Alopecia.

pubmed.ncbi.nlm.nih.gov

Background: Though androgenetic alopecia (Androgenetic Alopecia) is one of the most common diseases affecting both sexes and all races, its pathogenesis is not completely clarified. The aim of this study was to investigate the role of the four major prostaglandins (PGs) (PGE2 , PGD2 , PGF2α , and PI2 or prostacyclin) in the pathogenesis of Androgenetic Alopecia in males and females.

Methods: Human scalp biopsies were obtained from 30 adults (17 males and 13 females) suffering from Androgenetic Alopecia and from 30 healthy adults (18 males and 12 females). In each subject, two skin biopsies were performed, one from the frontal bald area and another one from the occipital area with normal hair growth. In the healthy group, biopsies were taken from both areas too. In each sample, all four PGs were measured.

Results: In the patient group, PGD2 and prostacyclin or PGI2 levels were increased in bald compared to haired scalp. On the contrary, measurements of PGE2 and PGF2α showed that they were diminished in bald areas compared to haired areas. PG levels in healthy samples were comparable to the haired areas.

Conclusion: These results support that there is a fine balance between these four proteins in scalp hair follicles, and its maintenance may be crucial for hair growth. Furthermore, their receptors could be potential targets for treatment of Androgenetic Alopecia.

 

[JaneyElizabeth]

Baldness is a disease now? That cuts both ways.

 

[JaneyElizabeth]

Could estrogen have a function somehow in balancing these four proteins? Would it be hard to alter or correct without estrogen? Just as the discovery of reductase inhibitors changed the way that we thought about androgen production, we might find that estrogen plays some role for both sexes in maintaining a full head of hair.

"Conclusion: These results support that there is a fine balance between these four proteins in scalp hair follicles, and its maintenance may be crucial for hair growth. Furthermore, their receptors could be potential targets for treatment of Androgenetic Alopecia."

Yeah, the paper's not posted, just the abstract. Interesting.

 

[waynakyo]

They knew PGs play a role back in the 1990s and I wonder why no one targeted them yet (clinically).
If I remember well Cotsarelis study shows that there is a causal link. That increasing PGD2-->inhibits growth. So people have been trying to block PGD2. We got stuff from China a while back. It is hard to figure out without people sticking to their regimen. Since PGD2 blockers - if they work - they likely slow bladness as opposed to show new growth.

 

[Armando Jose]

But, we must know if it is the cause or effect of hair loss....

 

[waynakyo]

I thought Cotsarelis showed reasonably compelling evidence that by increasing pgd2 ==> baldness.

 

[Armando Jose]

​

Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia​

We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice

Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (Androgenetic Alopecia); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D[2] synthase (PTGDS) is elevated at ...

www.ncbi.nlm.nih.gov

Also Cots did not use scalp hairs in human hair culture
"Briefly, human hair follicles in growth phase (anagen) were isolated from face and brow-lift tissue obtained from plastic surgeons."

 

[ElToso]

I find the role of PGI2 interesting, I was not aware of it.

https://www.hairlosstalk.com/interact/threads/it-begins-i-purchased-all-the-items-for-the-swisstemple-prostaglandin-protocol-wish.98121/page-41

The mechanism and mitigation of niacin-induced flushing

To summarise the metabolic responses to niacin that can lead to flushing and to critically evaluate flushing mitigation research.This comprehensive review of the mechanism of action of niacin-induced flushing critically evaluates research regarding flushing ...

www.ncbi.nlm.nih.gov

NSAIDs have the ability to block production of PGD2, PGE2 and PGI2

"The production of PGI2 and PGD2 decreases after repetitive administration of niacin in parallel with the development of flushing tolerance"

The Effect of the Drug Minoxidil on Hair Growth

Following the oral administration of minoxidil for recalcitrant hypertension widespread hair growth was observed, including reversal of male pattern hair loss. It has been subsequently shown that the application of a topical solution of minoxidil to the scalp is also...

link.springer.com

Most recently it has been observed to block the synthesis of PGI2. No cytoplasmic binding protein has been demonstrated.

 

[ElToso]

(PDF) Prostaglandins in androgenetic alopecia in 12 men and 4 female

PDF | Androgenetic alopecia (Androgenetic Alopecia) is the most common form of hair loss in humans. Evidence suggests the participation of prostaglandins in the... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

It is interesting that this receptor is not overexpressed
in our patients. Perhaps research on treatment should focus on drugs that target PTGDS activity and
not PTGDR2.

Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes - PubMed

Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (Androgenetic Alopecia) patients and to functionally inhibit hair growth. However, its precise mechanism in Androgenetic Alopecia has yet to be clearly defined. Although testosterone plays a critical role in the...

pubmed.ncbi.nlm.nih.gov

Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells - PubMed

Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (Androgenetic Alopecia). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood. The function of PGD2-induced expression of the androgen receptor (AR), DP2...

pubmed.ncbi.nlm.nih.gov

 

[waynakyo]

Perhaps this helps explain why this is such a hard one to solve. (not hair loss related)

https://www.jimmunol.org/content/jimmunol/192/1/459.full.pdf

The effects of PGD2 are extremely context dependent. It can have pro- or anti-inflammatory effects in clinically important pathological conditions.
..
Collectively, these results show that when hematopoietic PGD synthase is overexpressed, tissue resident cell–derived PGD2 suppresses skin inflammation via DP in the early phase, but hematopoietic lineage cell– derived PGD2 stimulates CRTH2 and promotes inflammation during the late phase. DP-mediated vascular barrier enhancement or CRTH2-mediated neutrophil activation may be responsible for these effects. Thus, PGD2 represents opposite roles in inflammation, depending on the disease phase in vivo

 

[StayPositive]

@balda look at this

 

[StayPositive]

We still don't know if pgd2 is the cause of male pattern baldness or just a byproduct of it


People tried seti in the past. Totally useless to take orally, too weak. I saw some success stories with topical seti, but it is costy and apparently its difficult to find quality seti . The others Pgd2 blockers like TM are way too powerful and cause sleep problems, but seems to completely halt shedding.



Seriously, i think Aspirin can be a good weapon along with pge2 analogs

I will try a new protocol to reduces pgd2 greatly with aspirin and Niacin (both oral and in high doses) . Since aspirin reduces pge2 too, i will take oral castor oil since ricinoleic acid has pge2 properties.

Aspirin can cause bleeding problems, that's why you must take vitamin k2 with it. Aspirin reduces glycin, it can causes hearing problems like tinnitus. So supplement yourself with glycin or collagen. Never take aspirin on an empty stomach.

I started today. I will tell you if i see a decrease in shedding or whatever

I have a good feeling this time

 

[waynakyo]

People tried seti in the past. Totally useless to take orally, too weak. I saw some success stories with topical seti, but it is costy and apparently its difficult to find quality seti . The others Pgd2 blockers like TM are way too powerful and cause sleep problems, but seems to completely halt shedding.

I have not heard of that, interesting. Re TM, people can cut the dose to a bare minimum, until there are not sides I presume? Clearly if they are having sides from a topical means it is quite powerful, going systemic and they are overdoing it. I don't think something need to completely halt shedding to work.

Be careful with Aspirin.

 

[StayPositive]

I have not heard of that, interesting. Re TM, people can cut the dose to a bare minimum, until there are not sides I presume? Clearly if they are having sides from a topical means it is quite powerful, going systemic and they are overdoing it. I don't think something need to completely halt shedding to work.

Be careful with Aspirin.

TM, even at extremely low dosage (like 10mg orally), inhibits 100% of the body pgd2. That's the problem, it's too powerful

 

[ElToso]

TM also binds to the Thromboxane Receptor, so it could give more sides. It also has a long half-life.
Timapiprant (OC) seems like the best choice. I don't know how much it costs on Alibaba on average.

It is interesting that this receptor is not overexpressed
in our patients. Perhaps research on treatment should focus on drugs that target PTGDS activity and
not PTGDR2.

I think this factor should not be underestimated.

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss - PubMed

Overall, ricinoleic acid, acteoside, amentoflavone, quercetin-3-O-rutinoside and hinokiflavone were predicted to be PTGDS inhibitors with good pharmacokinetic properties and minimal adverse skin reactions. These compounds have the highest potential for further in vitro and in vivo investigation...

pubmed.ncbi.nlm.nih.gov

Overall, ricinoleic acid, acteoside, amentoflavone, quercetin-3-O-rutinoside and hinokiflavone were predicted to be PTGDS inhibitors with good pharmacokinetic properties and minimal adverse skin reactions. These compounds have the highest potential for further in vitro and in vivo investigation with the aim of developing safe and high-efficacy hair loss treatment.

 

[Isneezedsohard]

I don’t f*** around with asprin. I’m sticking to a niacin flush— castor oil protocol. Bro science— but I feel like 1-2mg every/every other night will keep PG levels down, and the stuff that does accumulate, I’ll flush every 3 nights with Niacin flush.

 

[StayPositive]

I don’t f*** around with asprin. I’m sticking to a niacin flush— castor oil protocol. Bro science— but I feel like 1-2mg every/every other night will keep PG levels down, and the stuff that does accumulate, I’ll flush every 3 nights with Niacin flush.

Your talking about 1-2g of niacin , right?

1000mg per day seems good. Take it every day, pgd2 is formed constantly

 

[StayPositive]

TM also binds to the Thromboxane Receptor, so it could give more sides. It also has a long half-life.
Timapiprant (OC) seems like the best choice. I don't know how much it costs on Alibaba on average.


I think this factor should not be underestimated.

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss - PubMed

Overall, ricinoleic acid, acteoside, amentoflavone, quercetin-3-O-rutinoside and hinokiflavone were predicted to be PTGDS inhibitors with good pharmacokinetic properties and minimal adverse skin reactions. These compounds have the highest potential for further in vitro and in vivo investigation...

pubmed.ncbi.nlm.nih.gov

English is not my native language, i don't understand the paper very well.

Does it say PGD2 could be not detrimental for hair?

 

[Isneezedsohard]

Your talking about 1-2g of niacin , right?

1000mg per day seems good. Take it every day, pgd2 is formed constantly

I’m just worried about liver toxicity if I take every day. That’s a lot :/

 

[Isneezedsohard]

English is not my native language, i don't understand the paper very well.

Does it say PGD2 could be not detrimental for hair?

No, it does seem to be bad for hair. It’s elevated in balding men, indicating it has a detrimental effect on follicles and scalp health