New Patent: The Perfect Wnt Agonist For Us? | Page 2 | HairLossTalk Forums

New Patent: The Perfect Wnt Agonist For Us?

Discussion in 'New Research, Studies, and Technologies' started by InBeforeTheCure, Jan 1, 2018.

  1. InBeforeTheCure

    InBeforeTheCure Established Member My Regimen

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    So apparently there's already a company behind this, called Surrozen (their website).

    Link to press release. There are some really impressive people behind this.

     
  2. Trichosan

    Trichosan Senior Member My Regimen

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    Between The Column Group and Surrozen, these people are no lightweights and will not be wasting their time on hype and snake oil. But start ups take time and then they will have FDA bullshit to deal with, an automatic 2-3 year jackoff.
     
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  3. NewUser

    NewUser Established Member

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    I'll say to 3 to 5 years. This is very promising by the looks of things. Garcia is a research prof at HHMI of which Elaine Fuchs was a researcher for a number of years. She also did some work on Wnt pathways and hair biology wrt cancer research. These people are heavyweights for sure.

    Drugs. Some day.
     
  4. Ikkaku

    Ikkaku Established Member

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    Nice, there are some baldies in the team.
     
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  5. dermrafok

    dermrafok Established Member My Regimen

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    I have not heard that news ... From a very reliable source.
     
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  6. dermrafok

    dermrafok Established Member My Regimen

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  7. InBeforeTheCure

    InBeforeTheCure Established Member My Regimen

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    Not really following them, but I'd be surprised if it ever hit the market for hair loss. Results were just too weak.
     
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  8. kiwipilu

    kiwipilu Experienced Member My Regimen

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    still in trials.
    Anyway even if results were "weak", there was regrowth. And we know that in term of density a low percentage of regrowth can make all difference between visible thinning and a normal looking full head of hairs. On the other side I am obviously always skeptical for drugs to regrowth something on receding hairline or bald crown. But for diffuse pattern, or people in early stages of hairloss this could be something... mby...
    Also I have no idea if we can definitely talk of maintenance(!) with such drugs but with my (very) limited knowledge and after I read your post this angle controls miniaturization. right? So...
     
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  9. tomJ

    tomJ Established Member My Regimen

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    Personally I believe Samumed would be a spectacular maintanance/ slight regrowth drug. I'd do something to get a lot of hair back them maintain with this.
     
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  10. NewUser

    NewUser Established Member

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    Drugs have saved more lives than any other medical technology in history. Drugs are the only thing so far that have grown hair during "in the man" clinical trials. Our cellular biology works by molecular signalling, so it is perfectly reasonable to use small molecule drugs to try and correct malfunctioning cells. Our bodies use big molecules, like proteins and sugars as building blocks and smaller molecules for signaling and inhibition. A newer class of drugs called jak-inhibitors are not going away and will be used for a number of immune-related disorders including Alopecia Areata, Alopecias universalis and totalis. And who knows, they may even work for Androgenetic Alopecia. We will know soon enough.
     
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  11. Georgie

    Georgie Senior Member My Regimen

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    Here’s a study https://www.sciencedaily.com/releases/2017/08/170814134816.htm
    Shows that JAK-stat pathway signaling, which produces excess lactate is beneficial for hair regrowth.
     
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  12. JLF

    JLF Established Member My Regimen

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  13. JLF

    JLF Established Member My Regimen

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    "An ideal anagen-inducing therapy would be effective via topical application, but in this study, we delivered Rspo2 via intradermal injection. Transdermal delivery of a 22 kD hydrophilic protein is impractical (Bos and Meinardi, 2000); therefore, alternative delivery methods would have to be devised. Microneedles porate/permeabilize skin in a relatively noninvasive manner, and might be suitable for this purpose (Hultstrom et al., 2014; van der Maaden et al., 2012). Once into the dermis, Rspo2 would likely have to be protected from degradation by proteolytic enzymes, perhaps by liposomal packaging. Whether such a formulation of Rspo2 remains active within the HF remains to be tested."

    https://www.sciencedirect.com/science/article/pii/S0022202X16310545
     
  14. Calchas

    Calchas Experienced Member My Regimen

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    Don't fly too high with your expecations with studies like this,cause you'll crash badly.
    There are thousands,possibly millions mechanisms,pathways,substances involved in normal hair growth,just discovering yet one more of them
    is not a big deal.
     
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  15. JLF

    JLF Established Member My Regimen

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    I'm mostly concerned about the huge role that wnt plays in the human body...
    I see a lot of cancer research involving the wnt pathway.
     
  16. Calchas

    Calchas Experienced Member My Regimen

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    @JLF Dude,WTF?Your regimen list is longer than my monthly supermarket receipt!
     
  17. Trichosan

    Trichosan Senior Member My Regimen

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    The man obviously has no time for p*rn. Incredible! But good.
     
  18. JLF

    JLF Established Member My Regimen

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    what can I say, it's a tough battle and I wished the list was shorter too haha
     
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  19. Samah Saleh

    Samah Saleh New Member My Regimen

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  20. NewUser

    NewUser Established Member

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    And how many of those "thousands" of pathways and substances discovered were followed up with clinical trials "in the man"? When they submit an IND application, they have to show reasonable expectation for safety and efficacy through basic research done in the lab with animal models. Can anyone point us to clinical trial results for those thousands of old hunches? I think the science is getting better with geneticists like Christiano, Christofk etc discovering new pathways and identifying drugs to target these pathways as a result. And it looks like big pharma is now willing to scoop up the research and try it in people. Mice are nice, but the science isn't complete without people trials. Technological breakthroughs happen when scientists are willing to try new things in different ways and with unpredictable results.
     
    #40 NewUser, Jan 9, 2018
    Last edited: Jan 9, 2018
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